Imidazole
Mostrando 13-24 de 412 artigos, teses e dissertações.
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13. Inclusion complexes and self-assembled cyclodextrin aggregates for increasing the solubility of benzimidazoles
Albendazole and fenbendazole are imidazole derivatives that exhibit broad spectrum activity against parasites, but the low solubility of these drugs considerably reduces their effectiveness. Complexation of albendazole and fenbendazole with cyclodextrins (β-cyclodextrin and hydroxypropyl-β-cyclodextrin) in both water and an aqueous solution of polyvinylpyr
Braz. J. Pharm. Sci.. Publicado em: 25/11/2019
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14. Are Imidazoles Versatile or Promiscuous in Reactions with Organophosphates? Insights from the Case of Parathion
Is the broad mechanistic versatility of imidazole towards organophosphates (OPs), that has inspired many catalysts and sensors, beneficial? Herein, a thorough analysis is given seeking to unravel this puzzle. For OPs from the P=O family, imidazole attacks the phosphorus atom exclusively (N-phosphorylates). With the P=S family which are less reactive, an unus
J. Braz. Chem. Soc.. Publicado em: 21/10/2019
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15. Reduction Potential of RuIII-Based Complexes with Potential Antitumor Activity and Thermodynamics of their Hydrolysis Reactions and Interactions with Possible Biological Targets: a Theoretical Investigation
In this article density functional theory (DFT)-based calculations were employed to investigate the electrochemistry of the antitumor ruthenium complexes trans-tetrachloro(dimethylsulfoxide)imidazole ruthenate(III) (NAMI-A) and trans-[tetrachlorobis(1.-indazole)ruthenate(III)] (KP1019), their hydrolysis products as well as their interactions with biological
J. Braz. Chem. Soc.. Publicado em: 2019-03
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16. Eco-Friendly Synthesis of 2,3-Dihydroquinazolin-4(1H)-ones Catalyzed by FeCl3/Al2O3 and Analysis of Large 1H NMR Diastereotopic Effect
In the present study, we have carried out a condensation reaction for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones from 2-amino-N-benzylbenzamide and different aromatic aldehydes using FeCl3 catalyst supported on Al2O3. It was demonstrated that this material can be used successfully for the nucleation of quinazolinones with good to excellent yield; furt
J. Braz. Chem. Soc.. Publicado em: 2019-01
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17. Studies on new substituted pyridazinones: synthesis and biological evaluation
We report herein the synthesis and pharmacological evaluation of a new series of 6-aryl-2-(imidazol-1-yl/1,2,4-triazol-1-yl)-2-methyl-4,5-dihydro-(2H)-pyridazin-3-one (3a-j) as potential anticonvulsant and antitubercular agents. The title compounds were prepared by reacting 6-aryl-4,5-dihydro-(2H)-pyridazin-3-one (2a-e) with formaldehyde and secondary cyclic
Braz. J. Pharm. Sci.. Publicado em: 29/11/2018
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18. Silver Complex of an N-Heterocyclic Carbene Ligand with Bulky Thiocarbamate Groups
The synthesis of a new N-heterocyclic carbene with bulky S-arylthiocarbamate substituents was devised from the condensation between 2-chloromethyl-4-methy-l,6-[3,5-bis(trifluoromethyl)-phenyl]-S-phenyl-N,N-dimethylthiocarbamate and imidazole, resulting in the proligand N,N’-bis[(2-S-(N’’,N’’-dimethylthiocarbamoyl)-5-methyl)phenylmethyl]imidazolium
J. Braz. Chem. Soc.. Publicado em: 2018-08
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19. Synthesis and Antibacterial Evaluation of 2-Ethyl-1-(4-substituted)phenyl-1 H-imidazole Derivatives as Open-Chain Analogues of 7-Alkoxyl-4,5-dihydro-imidazo[1,2-a]quinolines
A novel series of 2-ethyl-1-(4-substituted)phenyl-1H-imidazole derivatives was designed, synthesized, and tested for its antibacterial activity against various bacterial strains. Most of the synthesized compounds showed potent inhibition of several Gram-positive and Gram-negative bacterial strains with minimum inhibitory concentration (MIC) values in the ran
J. Braz. Chem. Soc.. Publicado em: 2018-04
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20. Harmonious interaction of incorporating CNTs and zeolitic imidazole frameworks into polysulfone to prepare high performance MMMs for CO 2 separation from humidified post combustion gases
Abstract Multi-walled carbon nanotubes (CNTs) and zeolitic imidazole frameworks (ZIF-301) were synergistically incorporated into glassy polysulfone (PSF) to prepare mixed-matrix membranes (MMMs) to separate CO2 from post combustion flue gas. The flexible MMMs rendering consistent distribution and improved adhesion of nanofillers with the polymer matrix were
Braz. J. Chem. Eng.. Publicado em: 2018-01
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21. Two novel Mg(II)-based and Zn(II)-based complexes: inhibiting growth of human liver cancer cells
Two new Mg(II)-based and Zn(II)-based coordination polymers, {[Mg3(BTB)(DMA)4](DMA)2}n (1, H3BTB=1,3,5-benzenetrisbenzoic acid, DMA=N,N-dimethylacetamide) and {(H2NMe2)2[Zn3(BTB)2(OH)(Im)](DMF)9(MeOH)7}n (2, Im=imidazole, DMF=N,N-dimethylformamide), have been successfully synthesized and structurally characterized under solvothermal conditions. 1 contains a
Braz J Med Biol Res. Publicado em: 18/12/2017
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22. Synthesis and Evaluation of Cytotoxic Effects of Amino-ester Derivatives of Natural α,β-Amyrin Mixture
Natural α,β-amyrins were isolated from endemic Brazilian Esenbeckia grandiflora Mart., and eight synthetic derivatives were obtained by esterification reactions with bromo acetate, followed by amine treatment. The structures of the all compounds were confirmed by 1H and 13C nuclear magnetic resonance (NMR), Fourier transform infrared (FTIR) and high-resolu
J. Braz. Chem. Soc.. Publicado em: 2017-11
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23. Degrading Pesticides with Waste Product: Imidazole-Functionalized Rice Husk Catalyst for Organophosphate Detoxification
Rice husk (RH) is one the largest agricultural waste products worldwide, and rice is one of the crops that use the most pesticides. Among these, organophosphates have been of increasing concern due to their high toxicity. Herein, we report the functionalization of RH with imidazole groups (RHIMZ) to obtain sustainable catalysts from waste for organophosphate
J. Braz. Chem. Soc.. Publicado em: 2017-09
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24. Introdução à físico-química orgânica utilizando um colorímetro artesanal - uma prática interdisciplinar
Herein, we propose an interdisciplinary experiment for undergraduate course that involves concepts of organic and physical chemistry. Firstly, we propose the synthesis of three nitrophenyl acetates, varying the substituent position. Afterwards, we describe the construction of a homemade colorimeter using inexpensive materials and LED as both emission and det
Quím. Nova. Publicado em: 2017-02