Synthesis and Antibacterial Evaluation of 2-Ethyl-1-(4-substituted)phenyl-1 H-imidazole Derivatives as Open-Chain Analogues of 7-Alkoxyl-4,5-dihydro-imidazo[1,2-a]quinolines

AUTOR(ES)

Sun, Xian-Yu, Liu, Mei-Yu, Zhong, Chun-Yan, Zheng, Gui-Lin, Lv, Ming-Yue, Jing, Bo-Tao, Pan, Chun-Yuan, Wang, Xin

FONTE

J. Braz. Chem. Soc.

DATA DE PUBLICAÇÃO

2018-04

RESUMO

A novel series of 2-ethyl-1-(4-substituted)phenyl-1H-imidazole derivatives was designed, synthesized, and tested for its antibacterial activity against various bacterial strains. Most of the synthesized compounds showed potent inhibition of several Gram-positive and Gram-negative bacterial strains with minimum inhibitory concentration (MIC) values in the range of 4-256 nmol mL-1 in vitro. The compound [2-ethyl-1-(4-pentoxy)phenyl-1H-imidazole] exhibited the most potent inhibitory activity. The MIC of this compound against S. aureus was found to be 8 nmol mL-1, smaller than that of the reference agents, ciprofloxacin and amoxicillin. Furthermore, the compound exhibited modest activity against several bacterial strains in a dose range of 8-256 nmol mL-1.

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