Hydrophilic Model Drug
Mostrando 1-12 de 18 artigos, teses e dissertações.
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1. Influence of different formulation variables on the performance of transdermal drug delivery system containing tizanidine hydrochloride: in vitro and ex vivo evaluations
The present study was aimed at preparation of transdermal patches of tizanidine HCl, evaluation of the effect of polymers on in vitro release pattern of the drug, and the effect of permeation enhancers on the penetration of the drug through the rabbit skin. Various proportions of hydrophilic (HPMC) and hydrophobic (Eudragit L-100) polymers were used with PEG
Braz. J. Pharm. Sci.. Publicado em: 08/04/2019
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2. Cefuroxime axetil loaded gastroretentive floating tabletsbased on hydrophilic polymers: preparation and in vitro evaluation
The aim of this work was to study the formulation and in vitro characterization of hydro dynamically balanced floating matrix tablets using Cefuroxime axetil (CA) as model drug. Different excipients such as hydroxy propyl methyl cellulose (HPMC) K15M, E5LV (gelling agent), sodium bicarbonate (gas generating agent) and sodium lauryl sulfate (SLS) (solubility
Brazilian Archives of Biology and Technology. Publicado em: 2012-04
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3. Physicochemical characterization of a hydrophilic model drug-loaded PHBV microparticles obtained by the double emulsion/solvent evaporation technique
Micropartículas de poli(3-hidroxibutirato-co-3-hidroxivalerato) (PHBV) contendo um fármaco modelo hidrofílico, o cloridrato de metformina (MH), foram obtidas pela técnica de emulsão múltipla/evaporação do solvente. Diversas formulações foram preparadas, com o objetivo de investigar a influência de cada composição sobre a eficiência de encapsula
Publicado em: 2010
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4. Synthesis and characterization of thermo-responsive particles of poly(hydroxybutirate-co-hydroxyvalerate)-b-poly(N-isopropylacrylamide)
A new kind of thermo-responsive particles were prepared by the self-assembly technique, comprising poly(hydroxyvalerate-co-hydroxybutirate)-b-poly(N-isopropylacrylamide)/ (PHBHV-b-PNIPAAm) block copolymers. The hydrophilic part PNIPAAm was synthesized by Reversible Addition- Fragmentation chain Transfer (RAFT) polymerization. Particles with core-shell morpho
Brazilian Journal of Physics. Publicado em: 2009-04
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5. Physicochemical characterization of a hydrophilic model drug-loaded PHBV microparticles obtained by the double emulsion/solvent evaporation technique
Micropartículas de poli(3-hidroxibutirato-co-3-hidroxivalerato) (PHBV) contendo um fármaco modelo hidrofílico, o cloridrato de metformina (MH), foram obtidas pela técnica de emulsão múltipla/evaporação do solvente. Diversas formulações foram preparadas, com o objetivo de investigar a influência de cada composição sobre a eficiência de encapsula
J. Braz. Chem. Soc.. Publicado em: 2008
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6. Desenvolvimento, caracterizaÃÃo e estudo de permeaÃÃo cutÃnea de diclofenaco de dietilamÃnio em sistemas tÃpicos nanoemulsionados
The nanoemulsions (NE) are transparent, isotropic and thermodynamically stable systems, formed spontaneously under a specific set of experimental conditions from mixtures of water and oil phases stabilized by a surfactant or a mixture of surfactant and cosufactant. Because of their properties, especially the ability to carry lipophilic and hydrophilic drugs
Publicado em: 2008
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7. Improved entrapment efficiency of hydrophilic drug substance during nanoprecipitation of poly(I)lactide nanoparticles
The purpose of this research was to improve the entrapment efficiency of a model hydrophilic drug substance, sodium cromoglycate, loaded inside polylactic acid nanoparticles by a modified nanoprecipitation method. The effect of formulation parameters was studied to improve the entrapment efficiency of the drug substance inside the nanoparticles. Several para
Springer-Verlag.
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8. Use of hydrophilic natural gums in formulation of sustained-release matrix tablets of tramadol hydrochloride
The objective of this work was to develop matrix sustained-release tablets of highly water-soluble tramadol HCl using natural gums (xanthan [X gum] and guar [G gum]) as cost-effective, nontoxic, easily available, and suitable hydrophilic matrix systems compared with the extensively investigated hydrophilic matrices (ie, hydroxypropyl methylcellulose [HPMC]/c
Springer-Verlag.
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9. Permeability barrier to hydrophilic solutes in Mycobacterium chelonei.
In order to define the permeability barrier to hydrophilic molecules in mycobacteria, we used as a model a smooth, beta-lactamase-producing strain of Mycobacterium chelonei. The rates of hydrolysis of eight cephalosporins by intact and sonicated cells were measured, and the permeability coefficient (P) was calculated from these rates by the method of Zimmerm
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10. Controlled Release Hydrophilic Matrix Tablet Formulations of Isoniazid: Design and In Vitro Studies
The aim of the present investigation was to develop oral controlled release matrix tablet formulations of isoniazid using hydroxypropyl methylcellulose (HPMC) as a hydrophilic release retardant polymer and to study the influence of various formulation factors like proportion of the polymer, polymer viscosity grade, compression force, and release media on the
Springer US.
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11. Microemulsions Containing Medium-Chain Glycerides as Transdermal Delivery Systems for Hydrophilic and Hydrophobic Drugs
We evaluated the ability of microemulsions containing medium-chain glycerides as penetration enhancers to increase the transdermal delivery of lipophilic (progesterone) and hydrophilic (adenosine) model drugs as well as the effects of an increase in surfactant blend concentration on drug transdermal delivery. Microemulsions composed of polysorbate 80, medium
Springer US.
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12. Development and Evaluation of oral multiple-unit and single-unit hydrophilic controlled-release systems
This study compared the release behavior of single-unit (tablets, capsules) and multiple-unit (minitablets in capsules) controlled-release systems of furosemide. The swelling and erosion behaviors of these systems, which contained the swellable hydrophilic polymers sodium alginate (high viscosity) and Carbopol 974P, were compared. Swelling and erosion experi
Springer-Verlag.