Synthesis and characterization of thermo-responsive particles of poly(hydroxybutirate-co-hydroxyvalerate)-b-poly(N-isopropylacrylamide)

AUTOR(ES)

Oliveira, Adriano Marim de, Oliveira, Pedro Carlos de, Santos, Amilton Martins dos, Zanin, Maria Helena Ambrosio, Ré, Maria Inês

FONTE

Brazilian Journal of Physics

DATA DE PUBLICAÇÃO

2009-04

RESUMO

A new kind of thermo-responsive particles were prepared by the self-assembly technique, comprising poly(hydroxyvalerate-co-hydroxybutirate)-b-poly(N-isopropylacrylamide)/ (PHBHV-b-PNIPAAm) block copolymers. The hydrophilic part PNIPAAm was synthesized by Reversible Addition- Fragmentation chain Transfer (RAFT) polymerization. Particles with core-shell morphology were obtained with hydrophilic outer shells and hydrophobic inner cores. Dexametasone acetate (DexAc) was used as a model drug with an encapsulation efficiency of 77%. The release of DexAc in aqueous solution was strongly dependent on temperature, suggesting that PHBHV-b-PNIPAAm particles can be used as a thermo-responsive carrier material with external control in a drug release system.

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