Hyaluronan
Mostrando 1-12 de 118 artigos, teses e dissertações.
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1. Effect of a new cross-linked hyaluronan gel on the staple line after sleeve gastrectomy in a rat model
Abstract Purpose: To evaluate the effect of a new cross-linked hyaluronan (NCHA) gel on healing of the staple line in an experimental sleeve gastrectomy. Methods: Eighteen rats were randomly divided into three groups. The control group (n = 6) received no medication. In the saline group (n = 6) and NCHA gel group (n = 6), saline and NCHA gel were respecti
Acta Cir. Bras.. Publicado em: 2018-02
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2. Arthropod venom Hyaluronidases: biochemical properties and potential applications in medicine and biotechnology
AbstractHyaluronidases are enzymes that mainly degrade hyaluronan, the major glycosaminoglycan of the interstitial matrix. They are involved in several pathological and physiological activities including fertilization, wound healing, embryogenesis, angiogenesis, diffusion of toxins and drugs, metastasis, pneumonia, sepsis, bacteremia, meningitis, inflammatio
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 10/11/2015
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3. Hyaluronidases and hyaluronan synthases expression is inversely correlated with malignancy in lung/bronchial pre-neoplastic and neoplastic lesions, affecting prognosis
We collected a series of 136 lung/bronchial and 56 matched lung parenchyma tissue samples from patients who underwent lung/bronchial biopsies and presented invasive carcinoma after lung surgery. The lung/bronchial samples included basal cell hyperplasia, squamous metaplasia, moderate dysplasia, adenomatous hyperplasia, severe dysplasia, squamous cell carcino
Braz J Med Biol Res. Publicado em: 28/08/2015
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4. Tissue hyaluronan expression, as reflected in the sputum of lung cancer patients, is an indicator of malignancy
Hyaluronan (HA) shows promise for detecting cancerous change in pleural effusion and urine. However, there is uncertainty about the localization of HA in tumor tissue and its relationship with different histological types and other components of the extracellular matrix, such as angiogenesis. We evaluated the association between HA and degree of malignanc
Braz J Med Biol Res. Publicado em: 08/05/2015
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5. Glucosamine and chondroitin sulfate association increases tibial epiphyseal growth plate proliferation and bone formation in ovariectomized rats
OBJECTIVE: The growth plate consists of organized hyaline cartilage and serves as a scaffold for endochondral ossification, a process that mediates longitudinal bone growth. Based on evidence showing that the oral administration of glucosamine sul
Clinics. Publicado em: 2014
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6. Role of the extracellular matrix in variations of invasive pathways in lung cancers
Among the most common features of highly invasive tumors, such as lung adenocarcinomas (AD) and squamous cell carcinomas (SqCC), is the massive degradation of the extracellular matrix. The remarkable qualitative and quantitative modifications of hyaluronidases (HAases), hyaluronan synthases (HAS), E-cadherin adhesion molecules, and the transforming growth fa
Braz J Med Biol Res. Publicado em: 11/01/2013
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7. Relevância clínica da concentração do ácido hialurônico no escarro e em espécimes tumorais de pacientes portadores de carcinomas de pulmão / Clinical relevance of the hyaluronan levels in the sputum and tumoral tissues of lung cancer patients
Introdução. O ácido hialurônico é um glicosaminoglicano não sulfatado presente na matriz extracelular. Vários estudos têm demonstrado que uma produção ou degradação aberrante dessa molécula tem influência no comportamento do câncer de mama, próstata, bexiga e pulmão. Desta forma, a dosagem do ácido hialurônico em tecidos e fluidos corporai
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 03/08/2012
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8. Expressão gênica da prolactina, do receptor de prolactina e das hialuronam sintases e a imunoistoquímica do ácido hialurônico e do receptor CD44 em úteros de camundongos fêmeas com hiperprolactinemia induzida pela metoclopramida, durante as fases do ciclo estral / Gene expression of the prolactin, of the prolactin receptor and of the hyaluronan synthases and immunohistochemistry of the hyaluronic acid and of the CD44 receptor in uterus of female mice with metoclopramide-induced hyperprolactinemia throughout the estrous cycle
OBJECTIVE: To evaluate the gene expression of prolactin, prolactin receptor and hialuronan sintase and immunohistochemistry of hyaluronic acid and CD44 in the uterus of female mice with metoclopramide-induced hyperprolactinemia throughout the estrous cycle. METHODS: 80 adult (100 days old) female virgin mice were randomly divided into two groups of 40 animal
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/04/2011
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9. Serum hyaluronan and collagen IV as non-invasive markers of liver fibrosis in patients from an endemic area for schistosomiasis mansoni: a field-based study in Brazil
Non-invasive markers of fibrosis have been used to diagnose liver fibrosis in a variety of diseases. Hyaluronic acid (HA) and collagen IV (C-IV) levels were measured in the sera of patients from an endemic area for schistosomiasis in Brazil to diagnose and to rank the intensity of liver fibrosis. Seventy-nine adult patients with schistosomiasis, in the age r
Memórias do Instituto Oswaldo Cruz. Publicado em: 2010-07
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10. Identificação do perfil de expressão dos splicings alternativos dos genes das hialuronidases em adenocarcinoma de próstata / Study of genetic polymorphism in children: searching for susceptibility genes and haplotypes
Hyaluronic acid (HA) is a component of the extracellular matrix that hydrates and maintains the osmotic balance of tissues. HA concentration is elevated in several cancers including prostate. Hyaluronidases (HAases) are a family of enzymes related to the spread of bacterial infections, toxins of venoms and probably cancer progression. Small fragments of HA a
Publicado em: 2008
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11. Serum laminin, type IV collagen and hyaluronan as fibrosis markers in non-alcoholic fatty liver disease
Hepatic fibrosis in patients with non-alcoholic fatty liver disease is associated with progression of the disease. In the present study, we analyzed the discriminative ability of serum laminin, type IV collagen and hyaluronan levels to predict the presence of fibrosis in these patients. In this preliminary report, we studied 30 overweight patients divided in
Brazilian Journal of Medical and Biological Research. Publicado em: 2005-05
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12. Estudo bioquimico e histoquimico do acido hialuronico no tecido interpublico de camundongo durante a prenhez, parto e pos-parto
The interpubic tissue in mice is known to rapidly adapt itself to the ali new demands imposed during pregnancy, partum and post-partum. The development of an interpubic ligament may be explained, in part, due to the modifications observed in the hydration of this tissue, as well as, the presence of hyaluronan (HA). The present study focuses on the presence o
Publicado em: 2005