Homology Biology
Mostrando 1-12 de 57 artigos, teses e dissertações.
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1. Efficacy of sertraline against Trypanosoma cruzi: an in vitro and in silico study
Abstract Background: Drug repurposing has been an interesting and cost-effective approach, especially for neglected diseases, such as Chagas disease. Methods: In this work, we studied the activity of the antidepressant drug sertraline against Trypanosoma cruzi trypomastigotes and intracellular amastigotes of the Y and Tulahuen strains, and investigated its
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 29/11/2018
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2. Identificação de miRNAs e seus alvos no genoma da soja com o uso de abordagens computacionais
MicroRNAs (miRNAs) são pequenas moléculas de ácido ribonucléico que não codificam proteína (non-coding ribonucleic acid - ncRNA), descobertas no início dos anos 1990, presentes em animais, plantas e vírus, as quais acreditava-se não possuir função no organismo. Porém, recentemente, descobriu-se que os miRNAs possuem papel regulatório na express�
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 20/06/2011
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3. Epidemiologia molecular dos vírus dengue em Goiânia-GO, 1994 - 2006: vigilância laboratorial e caracterização dos sorotipos circulares / Molecular epidemiology of dengue virus in Goiânia, 1994-2006: laboratorial surveillance and characterization of circulate serotypes
Nowadays, dengue constitute the major public health problem, because is relevant cause of illness and death between thousands people that resident in the tropical and subtropical regions in world. The dengue virus is classified as four serotypes (DENV-1, 2, 3 and 4) according to antigenic differences and characterized intra-typical groups called genotypes. T
Publicado em: 2008
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4. Análise da via de regulação gênica por ácido retinóico: uma abordagem por bioinformática e biologia estrutural / Analysis of retinoic acid pathway: an approach by bioinformatics and structural biology.
As vias de sinalização celular por meio de moléculas são um dos principais meios de controle funcional de um organismo. O entendimento das funções de moléculas sinalizadoras facilita a compreensão das vias metabólicas de um organismo, assim possibilitando uma melhor compreensão de vários eventos biológicos e também de várias doenças. A sinaliz
Publicado em: 2008
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5. Clustering of Schistosoma mansoni mRNA sequences and analysis of the most transcribed genes: implications in metabolism and biology of different developmental stages
The study of the Schistosoma mansoni genome, one of the etiologic agents of human schistosomiasis, is essential for a better understanding of the biology and development of this parasite. In order to get an overview of all S. mansoni catalogued gene sequences, we performed a clustering analysis of the parasite mRNA sequences available in public databases. Th
Memórias do Instituto Oswaldo Cruz. Publicado em: 2002-10
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6. Herpesvirus saimiri encodes a functional homolog of the human bcl-2 oncogene.
Here we demonstrate that open reading frame 16 (ORF16) of the oncogenic herpesvirus saimiri protects cells from heterologous virus-induced apoptosis. The BH1 and BH2 homology domains are highly conserved in ORF16, and ORF16 heterodimerizes with Bcl-2 family members Bax and Bak. However, ORF16 lacks the core sequence of the conserved BH3 homology domain, sugg
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7. 1,2,3 = 2,3,4: A solution to the problem of the homology of the digits in the avian hand
Persistent contradictions in well supported empirical findings usually point to important scientific problems and may even lead to exciting new insights. One of the most enduring problems in evolutionary biology is the apparent conflict between paleontological and embryological evidence regarding the homology of the digits in the avian hand (1, 2). We propos
The National Academy of Sciences.
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8. Molecular approaches to dysmorphology.
The biochemical and physiological defects underlying human dysmorphic syndromes can now be approached using techniques of molecular biology. The genetic component of the causation of the dysmorphology can be studied in isolation from the environmental component by using large, rare families which exhibit the same phenotype as more complex multifactorial diso
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9. Human T-cell lymphotropic virus type III shares sequence homology with a family of pathogenic lentiviruses.
The etiologic agent of the acquired immune deficiency syndrome, human T-cell lymphotropic virus type III (HTLV-III), has recently been shown to morphologically resemble and share sequence homology with visna virus, a pathogenic lentivirus. Molecular hybridization, heteroduplex mapping, and DNA sequence analyses were used to compare HTLV-III to other lentivir
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10. An organism-specific method to rank predicted coding regions in Trypanosoma brucei
Genome annotation in differently evolved organisms presents challenges because the lack of sequence-based homology limits the ability to determine the function of putative coding regions. To provide an alternative to annotation by sequence homology, we developed a method that takes advantage of unusual trypanosomatid biology and skews in nucleotide compositi
Oxford University Press.
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11. The Mouse Genome Database (MGD): integration nexus for the laboratory mouse
The Mouse Genome Database (MGD) is the community database resource for the laboratory mouse, a key model organism for interpreting the human genome and for understanding human biology and disease (http://www.informatics.jax.org). MGD provides standard nomenclature and consensus map positions for mouse genes and genetic markers; it provides a curated set
Oxford University Press.
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12. Identification of Potential Vaccine and Drug Target Candidates by Expressed Sequence Tag Analysis and Immunoscreening of Onchocerca volvulus Larval cDNA Libraries
The search for appropriate vaccine candidates and drug targets against onchocerciasis has so far been confronted with several limitations due to the unavailability of biological material, appropriate molecular resources, and knowledge of the parasite biology. To identify targets for vaccine or chemotherapy development we have undertaken two approaches. First
American Society for Microbiology.