Hemoglobin Phenotypes
Mostrando 1-12 de 31 artigos, teses e dissertações.
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1. Whole-genome duplication and hemoglobin differentiation traits between allopatric populations of Brazilian Odontophrynus americanus species complex (Amphibia, Anura)
Abstract Two allopatric populations of Brazilian diploid and tetraploid Odontophrynus americanus species complex, both from São Paulo state, had their blood hemoglobin biochemically analyzed. In addition, these specimens were cytogenetically characterized. Biochemical characterization of hemoglobin expression showed a distinct banding pattern between the al
Genet. Mol. Biol.. Publicado em: 27/06/2019
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2. Characterization of alpha thalassemic genotypes by multiplex ligation-dependent probe amplification in the Brazilian population
Alpha-thalassemia is the most common inherited disorder of hemoglobin synthesis. Genomic deletions involving the alpha-globin gene cluster on chromosome 16p13.3 are the most frequent molecular causes of the disease. Although common deletions can be detected by a single multiplex gap-PCR, the rare and novel deletions depend on more laborious techniques for th
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-01
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3. Haptoglobin gene subtypes in three Brazilian population groups of different ethnicities
Haptoglobin is a plasma hemoglobin-binding protein that limits iron loss during normal erythrocyte turnover and hemolysis, thereby preventing oxidative damage mediated by iron excess in the circulation. Haptoglobin polymorphism in humans, characterized by the Hp*1 and Hp*2 alleles, results in distinct phenotypes known as Hp1-1, Hp2-1 and Hp2-2, whose frequen
Genetics and Molecular Biology. Publicado em: 26/06/2009
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4. Haptoglobin genotypes in sickle cell disease / Genotipos da haptoglobina nas doenças falciformes
Oxidative stress, particularly in the endothelium, exerts a strong influence on the genesis of sickle cell disease (SCD) vasoocclusion and, consequently, on patients clinical evolution and survival. The pathophysiology of SCD is centered on the polymerization property of the desoxy-hemoglobin (Hb) S, but genetic factors can act as modulators of its clinical
Publicado em: 2009
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5. Polymorphism of human haptoglobin and its clinical importance
Haptoglobin (Hp) is a plasma glycoprotein, the main biological function of which is to bind free hemoglobin (Hb) and prevent the loss of iron and subsequent kidney damage following intravascular hemolysis. Haptoglobin is also a positive acute-phase protein with immunomodulatory properties. In humans, the HP locus is polymorphic, with two codominant alleles (
Genetics and Molecular Biology. Publicado em: 2008
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6. Contribuição ao estudo da hematologia de bezerros da raça nelore, originados por meio da técnica de transferência nuclear de célula somática (TNCS) - Clonagem / Contribution to the study of hematology of Nelore calves produced by somatic cell nuclear transfer
A presente pesquisa teve a finalidade de estudar a hematologia de bezerros clonados da raça Nelore, originados por meio da técnica de transferência nuclear de células somáticas (TNCS) por meio da avaliação do quadro eritrocitário, da dinâmica dos tipos de hemoglobina e do metabolismo do ferro destes animais durante o primeiro mês de vida. O delinea
Publicado em: 2008
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7. Influencia do polimorfismo da haptoglobina na retinopatia diabetica em uma amostra da população brasileira / Haptoglobin polymorphism and diabetic retinoplasthy in a Brazilian population
Haptoglobin (Hp) is an acute phase protein with antioxidant and immunomodulatory properties. Three main genotypes/phenotypes (Hp1-1, Hp2-1, Hp2-2) show distinct efficiencies in these activities and have been associated with susceptibility and outcome in several diseases, including diabetes mellitus (DM). It has been suggested that Hp polymorphism may influen
Publicado em: 2007
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8. Analysis of genetic susceptibility to mercury contamination evaluated through molecular biomarkers in at-risk Amazon Amerindian populations
We investigated Individual differences in susceptibility to methylmercury (MeHg) contamination and its relationship with polymorphisms of the detoxifying enzyme glutathione S-transferase (GST). In Brazil, some Amerindian tribes from the Amazon region have an increased level of mercury in their hair. Samples of hair and blood were taken from inhabitants of tw
Genetics and Molecular Biology. Publicado em: 2005-12
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9. DISTRIBUIÇÃO DE VARIANTES DE HEMOGLOBINA EM DIFERENTES LOCALIDADES DE PORTO VELHO - RO
The genetic structure of Rondônia State is very heterogeneous due to the high migration indexes observed mainly from the second half of the Twentieth Century on. Since it is an endemic region for Malaria, we were able to observe an artificial selection in the fixation of some genes, from among the S an C hemoglobins variants. However, despite having a signi
Publicado em: 2005
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10. Avaliação do polimorfismo de grupos sanguíneos e fenótipo de hemoglobinas em um grupo de universitários de São José do Rio Preto, SP
The studies of the phenotypes of the blood groups are important for blood transfusions, for obstetrics, neonatology and law medicine, apart from its application in anthropology where it can be used as genetic markers in population studies. Works with hemoglobin polymor-phisms as a genetic marker of populations has been increased over the last few years, part
Revista Brasileira de Hematologia e Hemoterapia. Publicado em: 2003-03
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11. Functional properties of the three hemoglobin phenotypes of Nelore cattle
Blood and stripped hemoglobin from Nelore cattle individuals were submitted to oxygen equilibrium experiments in both gasometric and spectrophotometric methods. No difference was detected in oxygen affinity and Bohr effect among Hb A, Hb B and Hb AB in experiments with both blood and stripped hemoglobin, in the presence and absence of the chloride ion. Howev
Genetics and Molecular Biology. Publicado em: 2002
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12. Analysis of Haptoglobin and Hemoglobin-Haptoglobin Interactions with the Neisseria meningitidis TonB-Dependent Receptor HpuAB by Flow Cytometry
Neisseria meningitidis expresses a two-component TonB-dependent receptor, HpuAB, which mediates heme-iron (Hm-Fe) acquisition from hemoglobin and hemoglobin-haptoglobin complexes. Due to genetic polymorphisms in the human haptoglobin gene, haptoglobin (and hemoglobin-haptoglobin) exists as three structurally distinct phenotypes. In this study, we examined th
American Society for Microbiology.