Polymorphism of human haptoglobin and its clinical importance

AUTOR(ES)

Wobeto, Vânia Peretti de Albuquerque, Zaccariotto, Tânia Regina, Sonati, Maria de Fátima

FONTE

Genetics and Molecular Biology

DATA DE PUBLICAÇÃO

2008

RESUMO

Haptoglobin (Hp) is a plasma glycoprotein, the main biological function of which is to bind free hemoglobin (Hb) and prevent the loss of iron and subsequent kidney damage following intravascular hemolysis. Haptoglobin is also a positive acute-phase protein with immunomodulatory properties. In humans, the HP locus is polymorphic, with two codominant alleles (HP1 and HP2) that yield three distinct genotypes/phenotypes (Hp1-1, Hp2-1 and Hp2-2). The corresponding proteins have structural and functional differences that may influence the susceptibility and/or outcome in several diseases. This article summarizes the available data on the structure and functions of Hp and the possible effects of Hp polymorphism in a number of important human disorders.

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