Helicobacter Pylori Pathogenicity
Mostrando 1-12 de 92 artigos, teses e dissertações.
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1. The heterogeneic distribution of Helicobacter pylori cag pathogenicity island reflects different pathologies in multiracial Malaysian population
ABSTRACT Background: Helicobacter pylori harbouring cag-pathogenicity island (cagPAI) which encodes type IV secretion system (T4SS) and cagA virulence gene are involved in inflammation of the gastric mucosa. We examined all the 27 cagPAI genes in 88 H. pylori isolates from patients of different ethnicities and examined the association of the intactness of c
Braz J Infect Dis. Publicado em: 2020-12
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2. The interplay between mutations in cagA, 23S rRNA, gyrA and drug resistance in Helicobacter pylori
ABSTRACT In this study, we evaluated the mutations of Helicobacter pylori associated with resistance to clarithromycin and levofloxacin. Furthermore, based on the proposed interaction between antimicrobial resistance and pathogenicity, we correlated the mutation profiles of the strains with the presence of the pathogenicity gene cagA. We analyzed 80 gastric
Rev. Inst. Med. trop. S. Paulo. Publicado em: 28/06/2018
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3. Helicobacter pylori with East Asian-type cagPAI genes is more virulent than strains with Western-type in some cagPAI genes
Abstract The severity of Helicobacter pylori-related disease is correlated with the presence and integrity of a cag pathogenicity island (cagPAI). cagPAI genotype may have a modifying effect on the pathogenic potential of the infecting strain. After analyzing the sequences of cagPAI genes, some strains with the East Asian-type cagPAI genes were selected for
Braz. J. Microbiol.. Publicado em: 2017-06
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4. Water-induced modulation of Helicobacter pylori virulence properties
While the influence of water in Helicobacter pylori culturability and membrane integrity has been extensively studied, there are little data concerning the effect of this environment on virulence properties. Therefore, we studied the culturability of water-exposed H. pylori and determined whether there was any relation with the bacterium’s ability to adher
Mem. Inst. Oswaldo Cruz. Publicado em: 2014-07
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5. Authors reply: cagE as a biomarker of the pathogenicity of Helicobacter pylori
Rev. Soc. Bras. Med. Trop.. Publicado em: 2014-06
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6. Investigation of the association between clinical outcome and the cag pathogenicity-island and other virulence genes of Helicobacter pylori isolates from patients with dyspepsia in Eastern Turkey
The aims of our work were to determine the presence of the cag pathogenicity-island (cag PAI) and other virulence genes of Helicobacter pylori recovered from patients with gastritis and peptic ulcer, and to investigate the correlation of these virulence genes with clinical outcome. The presence of the cagA, the promoter regions of cagA, cagE, cagT, and the l
Braz. J. Microbiol.. Publicado em: 2013-12
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7. cagE as a biomarker of the pathogenicity of Helicobacter pylori
IntroductionHelicobacter pylori infection is associated with gastro-duodenal diseases. Genes related to pathogenicity have been described for H. pylori and some of them appear to be associated with more severe clinical outcomes of the infection. The present study investigates the role of cagE as a pathogenicity biomarker of H. pylori compare it to cagA, vacA
Rev. Soc. Bras. Med. Trop.. Publicado em: 2013-04
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8. Helicobacter pylori e polimorfismos em enzimas de reparo de DNA e de sÃntese de Ãxido nÃtrico no cÃncer gÃstrico / Helicobacter pylori infection and polymorphisms in DNA repair enzymes and iNOS in gastric cancer
Gastric cancer is the most deadly malignant neoplasia worldwide, with high incidence in Brazil and Helicobacter pylori infection is a well-established risk factor. Depending on the presence of virulence genes such as cagA, cagE, vacA and virB11, H. pylori can cause differentiated inflammatory responses, with large amounts of nitric oxide (NO) generated prima
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 02/08/2010
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9. Implicação de genes da zona de plasticidade e da ilha de patogenicidade cag (PAIcag) de Helicobacter pylori no desenvolvimento de doenças gastroduodenais / Implication of Helicobacter pulori plasticity region and cag pathogenicity island (cagPAI) genes on the development of gastroduodenal diseases
Helicobacter pylori is a Gram-negative, spiral-shaped, flagellated, micro-aerophilic bacterium, included in the Helicobacteraceae family, which infects the human stomach cronically. H. pylori infection has a worldwide distribution and is associated with the development of several gastroduodenal diseases, such as gastritis, peptic ulcer disease (PUD) and its
Publicado em: 2007
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10. Gastric precancerous lesions and Helicobacter pylori infection in relatives of gastric cancer / PrevalÃncia de lesÃes precursoras do cÃncer gÃstrico e do Helicobacter pylori em familiares de pacientes com cÃncer gÃstrico
Infection by Helicobacter pylori, a bacterial species classified by WHO as being carcinogenic (group I) affects more than half the world population. First-degree relatives to patients with gastric cancer are at increased risk of developing gastric cancer. The present study evaluated the prevalence of precursor lesions of gastric cancer and infection by Helic
Publicado em: 2004
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11. Helicobacter pylori (HP) gastric colozation and cytotoxin associated gene A (cagA) : relationship with cell proliferation and apoptosis / "Colonização gástrica por Helicobacter pylori associada à citotoxina do gene A (cagA): relação com proliferação celular e apoptose"
HP, uma bactéria gram-negativa envolvida na patogênese do tecido gastroduodenal, foi classificada como carcinogênico classe I em 1994. Seus mecanismos são pouco entendidos, mas a presença da ilha de patogenicidade (PAI) é fator importante de virulência. PAI sugere aumento da proliferação celular, diminuindo a apoptose. A detecção do HP e da PAI (c
Publicado em: 2004
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12. Acute inflammatory response in the stomach of BALB/c mice challenged with coccoidal Helicobacter pylori
An experimental murine model was used to verify the viability and pathogenicity of coccoid Helicobacter pylori. For this purpose, 27 BALB/c mice were inoculated intragastrically with 1 ml broth culture (10(8)organisms/ml) of a coccoid H. pylori clinical isolate. The animals were divided into two groups. Nine were infected on a one-time basis (GA1) and 18 wer
Memórias do Instituto Oswaldo Cruz. Publicado em: 2002-12