Hedgehog Pathway
Mostrando 1-12 de 71 artigos, teses e dissertações.
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1. Roles of Hedgehog signaling pathway in adipogenic differentiation potential of porcine adipose-derived mesenchymal stem cells
ABSTRACT This study examined the effects of purmorphamine and cyclopamine, classical agonists and inhibitors of the Hedgehog (Hh) signaling pathway, in the adipogenic differentiation of porcine adipose-derived mesenchymal stem cells (AMSC) to investigate the roles underlying adipogenic differentiation in AMSC. Porcine-derived AMSC were established, and the H
R. Bras. Zootec.. Publicado em: 29/11/2018
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2. Molecular basis of basal cell carcinoma
Abstract: Basal cell carcinoma is the most common cancer, presenting low mortality but high morbidity, and it has as risk factor exposure to sunlight, especially UVB spectrum. The most important constitutional risk factors for basal cell carcinoma development are clear phototypes (I and II, Fitzpatrick classification), family history of basal cell carcinoma
An. Bras. Dermatol.. Publicado em: 2017-08
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3. Wound healing - A literature review
Abstract: Regeneration and tissue repair processes consist of a sequence of molecular and cellular events which occur after the onset of a tissue lesion in order to restore the damaged tissue. The exsudative, proliferative, and extracellular matrix remodeling phases are sequential events that occur through the integration of dynamic processes involving solub
An. Bras. Dermatol.. Publicado em: 2016-10
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4. Análise de genes diferencialmente expressos nas vias de sinalização (Hedgehog e Wnt) em carcinomas basocelulares humanos
Hedgehog (HH) and Wingless-Int (Wnt) signaling pathway are related to the process of cellular proliferation, differentiation, angiogenesis, matrix remodeling and homeostasis of stem cells. Over the years, several mutations in HH signaling pathway have been identified, including the loss of function mutations in ptch1 and the gain of function mutations in smo
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 16/04/2012
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5. Avaliação da via do hedgehog nas hepatites crônicas B e C : da fibrose zero até a cirrose associada ou não ao carcinoma hepatocelular
Ativação da via do Hedgehog (Hh) promove vários processos que ocorrem durante o reparo fibrogênico hepático. O papel da via do Hh na lesão causada pela hepatite crônica B e C ainda não foi investigado. Estudos de expressão global em carcinomas hepatocelulares (CHC) demostraram a ativação da via do Hh em pacientes com CHC relacionados à infecção
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 17/03/2010
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6. Mecanismos de transdução de sinal envolvidos com a diferenciação de osteoblastos e osteocitos / Signal transduction activated during differentiation of osteoblsts and osteocytes
The main goal of this work was to investigate the signal transduction pathways triggered during the bone cells differentiation. In this way, several molecular aspects of this process were analyzed. Src kinase modulation by the low molecular weight protein tyrosine phosphatase (LMWPTP) was essential for the occurrence of the differentiation induced by ascorbi
Publicado em: 2008
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7. Estudo imunoistoquimico da incorporação de enxerto alogeno com proteina morfogenetica do osso-2 na mandibula de rato
Large bone defects can be managed by autogenous graft; however limitations in this source have induced research for new materials to replace autogenous graft. The incorporation of autoclaved alogenous bone graft associated to recombinant human bone morphogenetic protein 2 (rhBMP-2) was the objective of this study. The study animals were 75 Wistar rats distri
Publicado em: 2004
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8. The you Gene Encodes an EGF-CUB Protein Essential for Hedgehog Signaling in Zebrafish
Hedgehog signaling is required for many aspects of development in vertebrates and invertebrates. Misregulation of the Hedgehog pathway causes developmental abnormalities and has been implicated in certain types of cancer. Large-scale genetic screens in zebrafish have identified a group of mutations, termed you-class mutations, that share common defects in so
Public Library of Science.
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9. RENKCTD11 is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma
Hedgehog signaling is suggested to be a major oncogenic pathway in medulloblastoma, which arises from aberrant development of cerebellar granule progenitors. Allelic loss of chromosome 17p has also been described as the most frequent genetic defect in this human neoplasia. This observation raises the question of a possible interplay between 17p deletion and
National Academy of Sciences.
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10. From fruitflies to mammals: mechanisms of signalling via the Sonic hedgehog pathway in lung development
The hedgehog signalling pathway has been implicated in many different processes in fly and vertebrate development. It is now known that the hedgehog cascade is crucial for the patterning of the early respiratory system. Hedgehog signalling in the lung involves Gli transcription proteins, but their potential downstream target genes have yet to be identified.
BioMed Central.
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11. Phosphorylation of the fused protein kinase in response to signaling from hedgehog.
The hedgehog gene (hh) of Drosophila melanogaster exerts both short- and long-range effects on cell patterning during development. The product of hedgehog is a secreted protein that apparently acts by triggering an intra-cellular signaling pathway, but little is known about the details of that pathway. The Drosophila gene fused (fu) encodes a serine/threonin
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12. Roughing up Smoothened: chemical modulators of Hedgehog signaling
Small-molecule antagonists of Hedgehog-pathway signaling, such as cyclopamine, have been known for some time. Now, small-molecule agonists of the Hedgehog pathway have also been identified. The finding that both antagonists and agonists target the protein Smoothened supports the emerging hypothesis that Smoothened may be regulated by endogenous small molecul
BioMed Central.