Hedgehog Pathway
Mostrando 13-24 de 71 artigos, teses e dissertações.
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13. The therapeutic potential of modulators of the Hedgehog-Gli signaling pathway
The discovery of small molecules that act as agonists and antagonists of the Hedgehog-Gli signaling pathway, which plays important roles in the embryo and adult, opens a new avenue for the treatment of diseases caused by aberrant suppression or activation of this complex pathway.
BioMed Central.
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14. iguana encodes a novel zinc-finger protein with coiled-coil domains essential for Hedgehog signal transduction in the zebrafish embryo
Signaling by lipid-modified secreted glycoproteins of the Hedgehog family play fundamental roles during pattern formation in animal development and in humans; dysfunction of Hedgehog pathway components is frequently associated with a variety of congenital abnormalities and cancer. Transcriptional regulation of Hedgehog target genes is mediated by members of
Cold Spring Harbor Laboratory Press.
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15. Agonizing Hedgehog
An approach using 'chemical genetics' has identified small-molecule agonists of the Hedgehog signaling pathway that may lead the way to drugs for chronic degenerative diseases.
BioMed Central.
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16. Therapeutic efficacy of sonic hedgehog protein in experimental diabetic neuropathy
Hedgehog proteins modulate development and patterning of the embryonic nervous system. As expression of desert hedgehog and the hedgehog receptor, patched-1, persist in the postnatal and adult peripheral nerves, the hedgehog pathway may have a role in maturation and maintenance of the peripheral nervous system in normal and disease states. We measured desert
American Society for Clinical Investigation.
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17. Regulation of patched by sonic hedgehog in the developing neural tube.
Ventral cell fates in the central nervous system are induced by Sonic hedgehog, a homolog of hedgehog, a secreted Drosophila protein. In the central nervous system, Sonic hedgehog has been identified as the signal inducing floor plate, motor neurons, and dopaminergic neurons. Sonic hedgehog is also involved in the induction of ventral cell type in the develo
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18. The magnitude of hedgehog signaling activity defines skin tumor phenotype
Gain-of-function mutations in SMO have been implicated in constitutive activation of the hedgehog signaling pathway in human basal cell carcinomas (BCCs). We used a truncated keratin 5 (ΔK5) promoter to assess the potential role of the human M2SMO mutant in BCC development in adult transgenic mice. ΔK5-M2SMO mouse epidermis is hyperproliferative, ex presse
Oxford University Press.
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19. Activation of the hedgehog pathway in advanced prostate cancer
BioMed Central.
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20. Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling
Prostate cancer is the most common solid tumor in men, and it shares with all cancers the hallmark of elevated, nonhomeostatic cell proliferation. Here we have tested the hypothesis that the SONIC HEDGEHOG (SHH)–GLI signaling pathway is implicated in prostate cancer. We report expression of SHH–GLI pathway components in adult human prostate cancer, often
National Academy of Sciences.
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21. The primary cilium coordinates early cardiogenesis and hedgehog signaling in cardiomyocyte differentiation
Defects in the assembly or function of primary cilia, which are sensory organelles, are tightly coupled to developmental defects and diseases in mammals. Here, we investigated the function of the primary cilium in regulating hedgehog signaling and early cardiogenesis. We report that the pluripotent P19.CL6 mouse stem cell line, which can differentiate in
Company of Biologists.
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22. Identification of a small molecule inhibitor of the hedgehog signaling pathway: Effects on basal cell carcinoma-like lesions
The link between basal cell carcinoma (BCC) and aberrant activation of the Hedgehog (Hh) signaling pathway has been well established in humans and in mouse models. Here we report the development of assays, including two novel in vitro BCC models, which allowed us to screen for Hh inhibitors and test their validity as potential treatments for BCC. We identifi
The National Academy of Sciences.
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23. Extensive phosphorylation of Smoothened in Hedgehog pathway activation
The transmembrane protein Smoothened (Smo) is activated in response to the extracellular protein signal, Hedgehog (Hh), and transmits this state of pathway activity into the cell. Previous studies in Drosophila have correlated pathway activation with Smo accumulation and increased phosphorylation. Using immunopurification and mass spectrometry, we identify h
National Academy of Sciences.
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24. Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium
A distinct pathway for ligand-stimulated lateral trafficking of the hedgehog protein Smoothened into cilia is described.
The Rockefeller University Press.