Grp78
Mostrando 1-12 de 113 artigos, teses e dissertações.
-
1. Adiponectin is protective against endoplasmic reticulum stress-induced apoptosis of endothelial cells in sepsis
Endoplasmic reticulum (ER) stress is a critical molecular mechanism involved in the pathogenesis of sepsis. Hence, strategies for alleviating this stress may be essential for preventing cardiovascular injuries under sepsis. Adiponectin is secreted by adipocytes and its levels are decreased in sepsis. The purpose of this study was to investigate the protectiv
Braz J Med Biol Res. Publicado em: 14/11/2018
-
2. Comparison of endoplasmic reticulum stress and mitochondrial biogenesis responses after 12 weeks of treadmill running and ladder climbing exercises in the cardiac muscle of middle-aged obese rats
The purpose of the present study was to compare the influence of aerobic exercise (AE) lasting 12 weeks to that of resistance exercise (RE) of the same duration on endoplasmic reticulum (ER) stress and mitochondrial biogenesis in the cardiac muscle of middle-aged obese rats. Obesity was induced in thirty 50-week-old male Sprague Dawley rats over 6 weeks by a
Braz J Med Biol Res. Publicado em: 30/07/2018
-
3. The protective effect of dexmedetomidine in a rat ex vivo lung model of ischemia-reperfusion injury
Abstract Purpose: To investigate the effect of dexmedetomidine (Dex) in a rat ex vivo lung model of ischemia-reperfusion injury. Methods: An IL-2 ex vivo lung perfusion system was used to establish a rat ex vivo lung model of ischemia-reperfusion injury. Drugs were added to the perfusion solution for reperfusion. Lung injury was assessed by histopathologic
Acta Cir. Bras.. Publicado em: 2018-01
-
4. Endoplasmic reticulum stress and renal lesion in mice with combination of high-fat diet and streptozotocin-induced diabetes
ABSTRACT PURPOSE : To investigate in the kidney the pathologic changes and expression of GRP78 and CHOP in the Kunming (KM) mice with combination of high-fat diet and streptozotocin-induced diabetes. METHODS : Sixty two male KM mice were randomly divided into a normal control (NC) group (n=20) and a high-fat diet (HFD) group (n=42). After a four-week dieta
Acta Cir. Bras.. Publicado em: 2016-03
-
5. Ellagic acid inhibits proliferation and induces apoptosis in human glioblastoma cells
PURPOSE: To investigate the anticancer activity of ellagic acid (EA) in U251 human glioblastoma cells and its possible molecular mechanism. METHODS: The cells were treated with EA at various concentrations for different time periods. Cell viability and cell proliferation were detected by cell counting kit-8(CCK-8) assay and live/dead assay respectively. Ce
Acta Cir. Bras.. Publicado em: 2016-02
-
6. Inibição do estresse do retículo endoplasmático restaura o conteúdo de ABCA-1 e o efluxo de colesterol em macrófagos tratados com albumina modificada por glicação avançada / Inhibition of endoplasmic reticulum stress restores the ABCA-1 protein level and cholesterol efflux in advanced glycated albumin-treated macrophages
Produtos de glicação avançada (AGE) prejudicam o metabolismo de lipoproteínas e o transporte reverso de colesterol, o que contribui para a aterosclerose no diabete melito (DM). Em particular, a albumina modificada por AGE (albumina-AGE) reduz a remoção de colesterol por diminuir o conteúdo do receptor ABCA-1 em macrófagos. Isto se vincula ao insulto
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 14/08/2012
-
7. Disfunção na resposta ao estresse do retículo endoplasmático em linfócitos de pacientes com transtorno de humor bipolar
Bipolar disorder (BD) is a severe chronic psychiatric disorder that has been related to several cellular dysfunctions, such as an impaired endoplasmic reticulum (ER) stress response. We aimed to evaluate the unfolded protein response (UPR) and the outcome of this cellular process in cultured lymphocytes from patients with BD and healthy subjects, assessing i
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2012
-
8. A expressão deficiente das chaperonas GRP78 e GRP94 conecta a sinalização de TLR4 com o estresse de retículo endoplasmático / Chaperone insuficiency of GRP78 and GRP94 links TLR4 signaling to endoplasmic reticulum stress
TLR4 activation and the induction of endoplasmic reticulum stress (ERS) are two of the most important mechanisms connecting excessive fat with insulin resistance. Recently, it was shown that activation of TLR4 can, per se, induce ERS, suggesting that TLR4 is a primary event in the induction of the cellular stress that contributes to increased inflammatory ge
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/04/2011
-
9. Padrões de expressão de GRP78 em mulheres com câncer de mama tratadas com antracíclicos / Patterns of GRP78 expression in breast cancer treated with adjuvant anthracycline-based chemotherapy
Introdução: Evidências pré-clínicas implicam GRP78 como um possível marcador de resistência em quimioterapia baseada em antracíclicos em câncer de mama. Objetivos: O presente estudo avalia a relação entre a expressão de GRP78 no retículo endoplasmático (RE) e na membrana celular (MC) e a sobrevida global (SG) e a sobrevida livre de progressão
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 11/08/2010
-
10. Identification of GRP75 as a novel PreS1 binding protein using a proteomics strategy
The PreS1 region of the L protein is important in cell attachment and consequently in hepatitis B virus (HBV) infectivity. To identify novel PreS1 interacting protein, we performed Glutathione-S-transferase (GST) pull-down, two-dimensional gel electrophoresis (2-DE) and mass spectrometry assays. Glucose-regulated proteins (GRP) 78 and 75 were found to bind P
Brazilian Journal of Microbiology. Publicado em: 2010-06
-
11. Identificação de proteínas que interagem com a porção citoplasmática C-terminal do receptor para Angiotensina II (AT1aR) em células de tecido renal / Identification of binding-partners interacting with the intracellular c-terminal domain of the angiotensin II receptor AT1aR in rat renal tissue
O receptor para Angiotensina II tipo 1 (AT1R) é expresso tanto em membrana apical quanto basolateral dos túbulos proximais renais. Embora haja evidências de diferenças funcionais entre receptores apicais e basolaterais, como, por exemplo, a dependência do processo de internalização de receptores apicais, mas não de basolaterais, para a efetivação d
Publicado em: 2010
-
12. Avaliação do efeito citoprotetor do extrato bruto das folhas de Eugenia uniflora L. (Pintanga) e de compostos bioativos isolados em células secretoras de insulina
Folhas de pitanga são popularmente utilizadas no tratamento alternativo do diabetes mellitus. Portanto, o objetivo deste trabalho foi avaliar a atividade antioxidante, citotóxica e citoprotetora dos extratos brutos das folhas de Eugenia uniflora L. e de compostos encontrados nos extratos: quercetina (QE) e miricetina (MI), além do efeito destes sobre a fu
Publicado em: 2010