Gm1 Ganglioside 1
Mostrando 1-12 de 209 artigos, teses e dissertações.
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1. Effects of ganglioside G(M1) and erythropoietin on spinal cord lesions in rats: functional and histological evaluations
OBJECTIVE: To evaluate the functional and histological effects of ganglioside G(M1) and erythropoietin after experimental spinal cord contusion injury. METHODS: Fifty male Wistar rats underwent experimental spinal cord lesioning using an NYU-Impactor device and were randomly divided into the following groups, which received treatment intraperitoneally. The
Clinics. Publicado em: 2016-06
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2. Estudo dos efeitos do monossialogangliosídeo (GM1) administrado pela via transdérmica por laser a baixa temperatura, após lesão medular experimental em ratos / Study the effects of monossialoganglioside (GM1) administered by transdermal laser at low temperature, the spinal cord injuries in rats
Objetivo: avaliar os efeitos do monossialogangliosídeo (GM1) administrado pela via de transdérmica por laser a baixa temperatura, após lesão medular experimental em ratos. Métodos: o estudo incluiu 40 ratos Wistar, machos, com idade entre 20 e 21 semanas, submetidos à lesão medular contusa pelo equipamento NYU Impactor, a altura de 25 mm, de acordo co
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 24/01/2012
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3. GM1 improves neurofascin155 association with lipid rafts and prevents rat brain myelin injury after hypoxia-ischemia
White matter injury characterized by damage to myelin is an important process in hypoxic-ischemic brain damage (HIBD). Because the oligodendrocyte-specific isoform of neurofascin, neurofascin 155 (NF155), and its association with lipid rafts are essential for the establishment and stabilization of the paranodal junction, which is required for tight interacti
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-06
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4. Modulation of ROS production in human leukocytes by ganglioside micelles
Recent studies have reported that exogenous gangliosides, the sialic acid-containing glycosphingolipids, are able to modulate many cellular functions. We examined the effect of micelles of mono- and trisialoganglioside GM1 and GT1b on the production of reactive oxygen species by stimulated human polymorphonuclear neutrophils using different spectroscopic met
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-10
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5. Obtenção do gangliosídio GM3 de baço de cachorro
Gangliosídios são glicolipídios que possuem em sua estrutura obrigatoriamente um derivado de ácido siálico. Estes compostos existem em grande quantidade nas membranas plasmáticas das células, exercem papel importante nos processos de diferenciação celular e neurotransmissão. Duas enzimas chaves controlam a biossíntese dos diferentes gangliosídios
Publicado em: 2010
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6. Experimental study with GM1 ganglioside and hyperbaric oxygenation in spinal cord injury in rats / Estudo dos efeitos do monossialogangliosídio (GM1) e da câmara de oxigenoterapia hiperbárica na lesão medular aguda em ratos
The objectives were to evaluate the effect of GM1 ganglioside, hyperbaric oxygen, and both in combination, in the treatment of experimental spinal cord lesions in rats. Thirty-two Wistar rats with spinal cord lesions were divided into four groups: one group received GM1 ganglioside, one was submitted to hyperbaric oxygen therapy, the third received both trea
Publicado em: 2009
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7. Comparison of the effect of ganglioside GM1 and the Nerve Growth Factor (NGF) on the expression of receiver of high affinity for NGF, TrkA and insulin in isolated pancreatic islets of NOD mice (non obese diabetic) / Comparação dos efeitos do gangliosideo GM1 e do fator de crescimento neural (NGF) sobre a expressão de receptor de alta afinidade para NGF, TrkA e insulina em ilhotas pancreaticas isoladas de camundongos NOD (diabetico não obeso)
The non-obese diabetic mice (NOD) lineage is characterized by developing type 1 diabetes mellitus (DM-1) naturally, bearing a similarity to DM-1 in human beings. The spontaneous manifestation of diabetes is characterized by gradual infiltration in pancreatic islets by mononuclear cells lymphocytes T (CD4+ and CD8+) and destruction of the ß-cells producers o
Publicado em: 2008
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8. Estudo da recuperação da função locomotora e histomorfométrica da lesão medular em ratos: efeitos da metilprednisolona e do gangliosídeo G(M1) / Locomotor function recovering and histomorphometric study of spinal cord injury in the rat: effects of methylprednisolone and ganglioside G(M1)
A metilprednisolona (MP) e o gangliosídeo GM-1 são drogas de uso clínico estabelecido para o tratamento da lesão medular em humanos, embora sua eficácia e seus mecanismos de ação ainda não sejam totalmente entendidos. O objetivo do presente trabalho foi avaliar os resultados da recuperação da função locomotora e comparar com as alterações histo
Publicado em: 2008
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9. Effects of methylprednisolone and ganglioside GM-1 on a spinal lesion: a functional analysis
OBJECTIVES: The pharmacological effects of methylprednisolone (MP) and ganglioside GM-1 on spinal injuries have been thoroughly investigated, but only a few studies have evaluated the interaction between these two drugs. METHODS: Twenty-four Wistar rats were subjected to contusive injury of the spinal cord produced by the NYU system. These animals were divid
Clinics. Publicado em: 2008
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10. Effect of GM1 ganglioside in the sciatic nerves of the NOD (non obse diabetic) / Estudo do efeito do gangliosideo GM1 sobre os nervos perifericos do camundongo NOD (Non Obese Diabetic)
A linhagem de camundongos NOD (non obese diabetic) desenvolve espontaneamente diabetes mellitus tipo 1 (DM-1) com marcante similaridade ao observado em humanos, que se estabelece entre 12ª e 24ª semana de vida. Os gangliosideos são glicoesfingolipídeos de membrana que contém ácido siálico em sua composição e estão presentes na maioria das células
Publicado em: 2007
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11. Estudo dos efeitos imuno moduladores de gangliosideos na inflamação/expressão do diabetes mellitus autoimune em camundongo Nod-Uni
The beta cells destruction on diabetes type 1 autoimmune knowledge was derivative from NOD (diabetic non obese) mouse as experimental model, which have demonstrated great potential for drugs or immunotherapy s study. In this model, the diabetes manifestation occurs spontaneously like the observed in human, among 128-248 week of life. The prevalence could be
Publicado em: 2005
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12. Biochemical characterization of the GM2 gangliosidosis B1 variant
The deficiency of the A isoenzyme of ß-hexosaminidase (Hex) produced by different mutations of the gene that codes for the alpha subunit (Tay-Sachs disease) has two variants with enzymological differences: the B variant consists of the absence of Hex A isoenzyme and the B1 variant produces an inactive Hex A isoenzyme for the hydrolysis of the GM2 gangliosid
Brazilian Journal of Medical and Biological Research. Publicado em: 2004-06