Experimental study with GM1 ganglioside and hyperbaric oxygenation in spinal cord injury in rats / Estudo dos efeitos do monossialogangliosídio (GM1) e da câmara de oxigenoterapia hiperbárica na lesão medular aguda em ratos

AUTOR(ES)

Raphael Martus Marcon

DATA DE PUBLICAÇÃO

2009

RESUMO

The objectives were to evaluate the effect of GM1 ganglioside, hyperbaric oxygen, and both in combination, in the treatment of experimental spinal cord lesions in rats. Thirty-two Wistar rats with spinal cord lesions were divided into four groups: one group received GM1 ganglioside, one was submitted to hyperbaric oxygen therapy, the third received both treatments, and the fourth received no treatment (control). There were no significant differences between the groups in the histological analysis, for any of the variables (necrosis, hemorrhage, hyperemia, cystic degeneration, p >0.06). Neither were there any significant differences in the comparison of left and right sides in the functional tests (p >0.06 for all). No significant differences were found in the locomotor ratings, in the comparison of groups at 2 days, 7 days, 21 days and 28 days after the surgical procedure. However, in the evaluation on day 14, Group 3, which received the combined therapy, showed a significantly higher BBB score than the other groups (p = 0.015). In the evaluation on day 28, there was a trend to Group 1 (GM1) and 3 (combined therapy) showed a higher BBB score than the group 4 (control), but with no significance (p=0,057). In conclusion, the is a benefit in the use of GM1 ganglioside, but with no significance and the therapeutic effect of GM1 in locomotor evaluation of rats submitted to spinal cord lesion is anticipated by hyperbaric oxygen therapy.

ASSUNTO(S)

gangliosídio gm1 spinal cord injuries ratos wistar traumatismos da medula espinhal oxigenoterapia hiperbárica gm1 ganglioside 1 wistar rats hyperbaric oxygenation

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