Glycogen Muscle Depletion
Mostrando 25-33 de 33 artigos, teses e dissertações.
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25. Lactic Acidosis as a Result of Iron Deficiency
Iron-deficient rats have an impaired work performance, even when their anemia is corrected by exchange transfusion. Muscle activity is associated with a higher blood lactate concentration than is observed in iron-replete animals. The accumulation of lactate is a result of excessive production as lactate clearance from the blood was shown to be unaffected. By
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26. Acute molecular response of mouse hindlimb muscles to chronic stimulation
Stimulation of the mouse hindlimb via the sciatic nerve was performed for a 4-h period to investigate acute muscle gene activation in a model of muscle phenotype conversion. Initial force production (1.6 ± 0.1 g/g body wt) declined 45% within 10 min and was maintained for the remainder of the experiment. Force returned to initial levels upon study completio
American Physiological Society.
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27. The development of topographical maps and fibre types in toad (Bufo marinus) glutaeus muscle during synapse elimination.
1. The toad glutaeus muscle consists of two muscle compartments. A study has been made of the topographical distribution of motor units in these compartments, in relation to the fibre types which arise during different stages of development. 2. Monoclonal antibodies to myosin allowed the distribution of fibre types to be determined. In mature muscles (from t
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28. Activity-dependent and -independent synaptic interactions during reinnervation of partially denervated rat muscle.
1. Reinnervation of adult rat fourth deep lumbrical muscles was studied, following extensive partial denervation of the hindfoot by crushing the lateral plantar nerve (LPN). Most muscles remained innervated by between one and five motor axons supplied by the sural nerve (SN). Intact SN motor units expanded as a result of collateral sprouting. Virtually compl
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29. A myosin II ATPase inhibitor reduces force production, glucose transport, and phosphorylation of AMPK and TBC1D1 in electrically stimulated rat skeletal muscle
Contraction-stimulated glucose transport by skeletal muscle appears to be caused by the cumulative effects of multiple inputs [potentially including AMP-activated protein kinase (AMPK), Ca2+ flux, and force production], making it challenging to isolate the roles of these putative regulatory factors. To distinguish the effects of force production from the dir
American Physiological Society.
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30. Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing
Glucose homeostasis is controlled by insulin in part through the translocation of intracellular glucose transporter 4 to the plasma membrane in muscle and fat cells. Akt/protein kinase B downstream of phosphatidylinositol 3-kinase has been implicated in this insulin-signaling pathway, but results with a variety of reagents including Akt1–/– and Akt
National Academy of Sciences.
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31. Effects of age on physiological, immunohistochemical and biochemical properties of fast-twitch single motor units in the rat.
1. Physiological, enzyme-histochemical, biochemical and morphometrical properties of fast-twitch single motor units were compared between young (3-6 months) and old rats (20-24 months) using the glycogen depletion technique. Monoclonal antibodies (mAbs) were used to identify the myosin heavy chain (MHC) composition in the muscle fibres of the motor unit (mot
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32. Energy metabolism of the untrained muscle of elite runners as observed by 31P magnetic resonance spectroscopy: evidence suggesting a genetic endowment for endurance exercise.
The purpose of this study was to investigate whether genetically determined properties of muscle metabolism contribute to the exceptional physical endurance of world-class distance runners. ATP, phosphocreatine, inorganic phosphate, and pH were quantitatively determined by 31P nuclear magnetic resonance spectroscopy in the wrist flexor muscles of elite long-
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33. The metabolic consequences of an increase in the frequency of stimulation in isolated ferret hearts.
1. The metabolic consequences of an increase in the frequency of stimulation were examined in isolated ferret hearts. Intracellular pH (pHi) and the intracellular concentrations of phosphocreatine ([PCr]i), inorganic phosphate ([Pi]i) and ATP were measured by 31P nuclear magnetic resonance (NMR) spectroscopy. 2. Increasing the stimulus rate from 0.1-0.7 to 2