Glutamatergic System
Mostrando 1-12 de 63 artigos, teses e dissertações.
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1. The role of NMDA receptor antagonists, amantadine and memantine, in schizophrenia treatment: a systematic review
Abstract Objective Schizophrenia is a complex and chronic psychiatric disorder. In recent years, studies have found glutamatergic system participation in its etiopathogenesis, especially through aberrant NMDA receptors functioning. Thus, drugs that modulate this activity, as amantadine and memantine, could theoretically be used in its treatment. To perform
Arch. Clin. Psychiatry (São Paulo). Publicado em: 28/11/2019
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2. Antinociceptive effect of PnTx4(5-5), a peptide from Phoneutria nigriventer spider venom, in rat models and the involvement of glutamatergic system
ABSTRACT Background: The venom of Phoneutria nigriventer spider is a source of numerous bioactive substances, including some toxins active in insects. An example is PnTx4(5-5) that shows a high insecticidal activity and no apparent toxicity to mice, although it inhibited NMDA-evoked currents in rat hippocampal neurons. In this work the analgesic activity o
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 12/08/2019
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3. Possible mechanisms of antinociception of methanol extract of Melastoma malabathricum leaves
ABSTRACT Melastoma malabathricum L., Melastomaceae, has been traditionally used to relieve diverse pain-related ailments. The objectives of the present study were to determine the antinociceptive activity of methanol extract of M. malabathricum leaves and to elucidate the possible mechanisms of antinociception involved using various rats' models. The extract
Rev. bras. farmacogn.. Publicado em: 2016-10
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4. Genetic association of single nucleotide polymorphisms in dystrobrevin binding protein 1 gene with schizophrenia in a Malaysian population
Dystrobrevin binding protein 1 (DTNBP1) gene is pivotal in regulating the glutamatergic system. Genetic variants of the DTNBP1 affect cognition and thus may be particularly relevant to schizophrenia. We therefore evaluated the association of six single nucleotide polymorphisms (SNPs) with schizophrenia in a Malaysian population (171 cases; 171 controls). Ass
Genet. Mol. Biol.. Publicado em: 2015-06
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5. Mecanismos de captação e toxicidade do metilmercúrio: Envolvimento do sistema glutamatérgico e do cálcio em fatias e mitocôndrias de ratos. / Mechanism of uptake and toxicity of methylmercury: Involvement of glutamatergic system and calcium em fatias e mitocôndrias de ratos.
O metilmercúrio (MeHg) é um contaminante ambiental altamente tóxico que pode ser bioacumulado em diferentes tecidos e consequentemente induzir disfunções celulares em diversos órgãos, especialmente no sistema nervoso central (SNC). Os mecanismos pelos quais o mercúrio (Hg) entra nos tecidos, se acumula e causa toxicidade em células e organelas ainda
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 22/01/2012
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6. Participação do sistema glutamatérgico do córtex pré-frontal medial ventral na modulação das consequências comportamentais do estresse de nado forçado / Participation of the glutamatergic system of the ventral medial prefrontal cortex in the modulation of behavioral consequences of forced swimming stress.
Acredita-se que quantidades elevadas de glutamato estejam relacionadas à neurobiologia da depressão e trabalhos recentes indicam que a quantidade de glutamato cortical está aumentada em pacientes depressivos quando comparada a indivíduos sadios. Dentre as estruturas corticais, o córtex pré-frontal medial ventral (CPFMv), dividido em infralímbico (IL)
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 20/07/2011
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7. Imunodetecção do receptor metabotrópico mGluR8 no núcleo arqueado do hipotálamo de ratos Wistar e estudo dos efeitos, no receptor, resultantes da exposição oral sub-crônica ao glutamato monossódico / Imunodetecction of mGluR8 receptor in the arcuate nucleus of the hypothalamus of Wistar rats and study of the effects, on the receptor, resulting from sub-chronic exposure to monosodium glutamate
Food is part of human culture not only associated to physiological needs. Food is composed of several molecules among them amino acids. Glutamate (GLU) is the anion of one of the main amino acids found in foods that, besides being part of the food composition, is a molecule essential for human physiology. It can also be ingested due to the use of the food ad
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 22/02/2011
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8. Efeitos comportamentais, neuroquímicos e metabólicos do tratamento com decanoato de nandrolona em camundongos
Desde a primeira síntese, isolamento e caracterização dos andrógenos, particularmente da testosterona em 1935, diversos homólogos sintéticos foram desenvolvidos com os objetivos de prolongar a atividade biológica, desenvolver administração parenteral e diminuir a atividade androgênica, classe denominada de esteróides anabólicos-andrógenos (EAA).
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2011
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9. The role of the cerebellum in schizophrenia: from cognition to molecular pathways
Beside its role in motor coordination, the cerebellum is involved in cognitive function such as attention, working memory, verbal learning, and sensory discrimination. In schizophrenia, a disturbed prefronto-thalamo-cerebellar circuit has been proposed to play a role in the pathophysiology. In addition, a deficit in the glutamatergic N-methyl-D-aspartate (NM
Clinics. Publicado em: 2011
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10. Study of antinociceptive and antiinflammatory monoterpene a,b-epoxy-carvone and its effect on glutamatergic neurotransmission. / Estudo da atividade antinociceptiva e anti-inflamatória do monoterpeno a,b-Epoxi-carvona e seu efeito sobre a neurotransmissão glutamatérgica
The a, b-epoxy-carvone (EC) monoterpene is found in many essential oils from plants, but can also be obtained through organic synthesis from the R-(-)-carvone. Previous studies have demonstrated that this compound exerts depressant effect on central nervous system (CNS), and is also known to have anticonvulsant effects, antioxidant and antimicrobial activiti
Publicado em: 2010
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11. Central actions of glucocorticoids in the control of body fluid homeostasis: Review
The involvement of the hypothalamic-pituitary-adrenal axis in the control of body fluid homeostasis has been extensively investigated in the past few years. In the present study, we reviewed the recent results obtained using different approaches to investigate the effects of glucocorticoids on the mechanisms of oxytocin and vasopressin synthesis and secretio
Brazilian Journal of Medical and Biological Research. Publicado em: 2009-01
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12. Integrated Cardio-Respiratory Mechanisms within the brainstem: Involvement of the Caudal Pressor Area, the Nucleus of the Solitary Tract and the Retrotrapezopid Nucleus. / Mecanismos Cardio-Respiratórios Integrados na Região Bulbar: Participação da Área Pressora Caudal, dos Núcleos do Trato Solitário e do Núcleo Retrotrapezóide.
Cardiovascular responses are integrated at different levels of the central nervous system (CNS). In the brainstem, there are different areas related to the cardiovascular control. It is well known that in the ventrolateral medulla there are, at least, three important regions involved with cardiovascular control: the rostral ventrolateral medulla (RVLM), the
Publicado em: 2009