Glibenclamide
Mostrando 25-36 de 159 artigos, teses e dissertações.
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25. Identification of mechanisms involved in the relaxation of rabbit cavernous smooth muscle by a new nitric oxide donor ruthenium compound
PURPOSE: The aim of this study was to evaluate the relaxation in vitro of cavernous smooth muscle induced by a new NO donor of the complex nitrosil-ruthenium, named trans-[Ru(NH3)4(caffeine)(NO)]C13 (Rut-Caf) and sodium nitroprusside (SNP). MATERIALS AND METHODS: The tissues, immersed in isolated bath systems, were pre-contracted with phenilephrine (PE) (1 �
Int. braz j urol.. Publicado em: 2012-10
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26. Antidiabetic activity of Pseudarthria viscida aqueous root extract in neonatal streptozotocin-induced NIDDM rats
The antidiabetic activity of the aqueous root extract of Pseudarthria viscida (L.) Wight & Arn., Fabaceae, was investigated in normal and neonatal streptozotocin (n2-STZ)-induced non insulin-dependent diabetes mellitus (NIDDM) rats and compared with glibenclamide as a reference standard. Two different doses (250 and 500 mg/kg) of the extract were administere
Rev. bras. farmacogn.. Publicado em: 06/09/2012
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27. Protective effect of oryzanol isolated from crude rice bran oil in experimental model of diabetic neuropathy
Several studies have implicated the involvement of poor glycemic control and oxidative/nitrosative stress in the development of diabetic neuropathic pain, an important microvascular complication affecting more than 50% of diabetic patients. However, lack of understanding of the underlying etiology, development of tolerance, inadequate relief and possible tox
Rev. bras. farmacogn.. Publicado em: 06/09/2012
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28. Participation of the NO/cGMP/K+ATP pathway in the antinociception induced by Walker tumor bearing in rats
Implantation of Walker 256 tumor decreases acute systemic inflammation in rats. Inflammatory hyperalgesia is one of the most important events of acute inflammation. The L-arginine/NO/cGMP/K+ATP pathway has been proposed as the mechanism of peripheral antinociception mediated by several drugs and physical exercise. The objective of this study was to investiga
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-06
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29. Allicin, a SUR2 opener: possible mechanism for the treatment of diabetic hypertension in rats
The garlic (Allium sativum L., Amaryllidaceae) has been popularly used in the treatment of diabetes and cardiac complications. In the present work, we have studied the possible mechanisms, sulfonylurea receptor (SUR) selectivity of allicin in diabetic hypertensive rats. Diabetic hypertension was induced by intraperitoneal injection of streptozotocin (50 mg/k
Rev. bras. farmacogn.. Publicado em: 12/04/2012
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30. Evaluation of antidiabetic, antihyperlipidemic and antioxidant effects of Boehmeria nivea (L.) Gaudich., Urticaceae, root extract in streptozotocin-induced diabetic rats
The potential role of 80% methanolic extract of Boehmeria nivea (L.) Gaudich., Urticaceae, root in the treatment of diabetes, along with its antihyperlipidemic and antioxidant effects, was studied in streptozotocin-induced diabetic male Wistar rats. Preliminary screening of the extract revealed the presence of polyphenolics and flavonoids. The animal study w
Revista Brasileira de Farmacognosia. Publicado em: 25/02/2011
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31. Effect of glibenclamide on antinociceptive effects of antidepressants of different classes
OBJECTIVES: The purpose of this work was to determine whether the intraperitoneal administration of glibenclamide as a K ATP channel blocker could have an effect on the antinociceptive effects of antidepressants with different mechanisms of action. METHODS: Three antidepressant drugs, amitriptyline as a dual-action, nonselective inhibitor of noradrenaline an
Clinics. Publicado em: 2011
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32. Papel dos canais K+ATP na resposta eletrofisiológica ao FSH e ao isoproterenol em células de Sertoli
Follicle-stimulating hormone (FSH) produces a dual effect on the membrane potential of Sertoli cells, with an initial rapid phase, which comprises a hyperpolarization for a period of seconds and a depolarization phase, wich occurs more slowly, within minutes. The depolarization phase involves calcium entry stimulated by FSH. Isoproterenol, an agonist of ¿-a
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2011
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33. CaracterizaÃÃo das vias neuro-humorais no retarde do esvaziamento gÃstrico de lÃquidos advindo da distensÃo mecÃnica atrial direita em ratos acordados. / Characterization of neuro-humoral pathways involved in delayed gastric emptying of liquids due to mechanical right atrial stretch in awake rats.
Right atrium mechanical stretch (AS) increases gastric motility in anesthetized rats. We aimed to study the effect of AS on gastric emptying (GE) in awake rats and the related neuro-humoral pathways ivolved. Male albino rats (N=361, 250-280g) had a silicone balloon inserted in the right atrium. After 24-h, the central venous pressure (CVP), heart rate (HR) a
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 26/02/2010
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34. Encapsulation and release characteristics of glibenclamide loaded calcium-alginate beads
The aims of this study were to formulate calcium-alginate beads containing glibenclamide, characterize the resulting microparticles, evaluate the release characteristics of this type of delivery system in an in vitro dissolution test, and compare it with two commercially available trademarks (Daonil® and Glibetab®). We obtained glibenclamide loaded calcium
Química Nova. Publicado em: 2010
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35. Uso de anti-hipertensivos e hipoglicemiantes por idosos, em Belo Horizonte, MG
Introduction: Changes in the epidemiological profile, coupled with demographic transition, the improvement in quality of life and technological advances, are characteristics of the aging phenomenon of Brazilian population, where are predominant the cardiovascular diseases. Among the main risk factors are arterial hypertension (HA) and diabetes mellitus (DM).
Publicado em: 2010
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36. Participação Do Cálcio Citosólico Sobre A Ação Espasmolítica Do Ácido Ent-7a-Acetoxitraquiloban-18-Óico E De Seu Derivado Hidroxilado Em Íleo Isolado De Cobaia / Partipation of cytosolic calcium in spasmolytic action of ent-7a-acetoxytrachyloban-18-oic acid and its hidroxylated derivated on guinea-pig ileum
From the stem bark of Xylopia langsdorfiana A. St.-Hil. &Tul. (Annonaceae), popularly known as pimenteria da terra, was isolated the diterpene ent-7-α-acetoxytrachyloban-18-oic acid (trachylobane-360) from which it was made a structural modification in which the acetoxy group was substituted by hydroxy generating the ent-7a-hidroxitrachyloban-18-oic aci
Publicado em: 2010