Glibenclamide
Mostrando 13-24 de 159 artigos, teses e dissertações.
-
13. Hypoglycemic and hypolipidemic effects of Solidago chilensis in rats
AbstractSolidago chilensis Meyen, Asteraceae, is traditionally used to treat inflammation. However, phytochemical and pharmacology investigations are lacking. This study evaluated the hypoglycemic and hypolipidemic effects of hydroalcoholic extract from S. chilensis aerial parts in rats. In oral glucose tolerance tests the rats received saline (0.5 ml/100 g)
Rev. bras. farmacogn.. Publicado em: 2015-06
-
14. Mechanisms involved in the vasorelaxant effects produced by the acute application of amfepramone
in vitro to rat aortic ringsAmfepramone (diethylpropion) is an appetite-suppressant drug used for the treatment of overweight and obesity. It has been suggested that the systemic and central activity of amfepramone produces cardiovascular effects such as transient ischemic attacks and primary pulmonary hypertension. However, it is not known whether amfepramone produces immediate vas
Braz J Med Biol Res. Publicado em: 27/03/2015
-
15. Pharmacological characterization of the relaxant effect induced by adrenomedullin in rat cavernosal smooth muscle
The aim of the present study was to determine the mechanisms underlying the relaxant effect of adrenomedullin (AM) in rat cavernosal smooth muscle (CSM) and the expression of AM system components in this tissue. Functional assays using standard muscle bath procedures were performed in CSM isolated from male Wistar rats. Protein and mRNA levels of pre-pro-AM,
Braz J Med Biol Res. Publicado em: 15/08/2014
-
16. Interactions of chitosan/genipin hydrogels during drug delivery: a QSPR approach
A hydrogel comprised of chitosan crosslinked using the low-toxicity crosslinker genipin was prepared, and the absorption of glibenclamide by the hydrogel was investigated. Optimized structures and their molecular electrostatic potentials were calculated using the AM1 method, and the results were used to evaluate the molecular interactions between the three c
Quím. Nova. Publicado em: 2014
-
17. Hypoglycemic and hypolipidemic activity of Ficus mollis leaves
The present research was designed to evaluate the hypoglycemic and hypolipidemic activity of ethyl acetate extract of Ficus mollis Vahl, Moraceae, against dexamethasone induced insulin resistance. Wistar albino rats were treated with dexamethasone (10 mg/kg) for ten days to induce insulin sensitivity. Hypoglycemic and hypolipidemic activity of ethyl acetate
Rev. bras. farmacogn.. Publicado em: 20/08/2013
-
18. The hydrogen sulfide donor, Lawesson's reagent, prevents alendronate-induced gastric damage in rats
Our objective was to investigate the protective effect of Lawesson's reagent, an H2S donor, against alendronate (ALD)-induced gastric damage in rats. Rats were pretreated with saline or Lawesson's reagent (3, 9, or 27 µmol/kg, po) once daily for 4 days. After 30 min, gastric damage was induced by ALD (30 mg/kg) administration by gavage. On the last day of t
Braz J Med Biol Res. Publicado em: 16/08/2013
-
19. Comparative effects of mature coconut water (Cocos nucifera) and glibenclamide on some biochemical parameters in alloxan induced diabetic rats
In the present study, comparative effects of mature coconut water (Cocos nucifera L., Arecaceae) and glibenclamide in alloxan induced diabetic rats were evaluated. Diabetes mellitus was induced in Sprague-Dawly rats using alloxan monohydrate (150 mg kg-1 body weight). Treatment with lyophilized form of mature coconut water and glibenclamide in diabetic rats
Rev. bras. farmacogn.. Publicado em: 26/03/2013
-
20. Role of the NO/K ATP pathway in the protective effect of a sulfated-polysaccharide fraction from the algae Hypnea musciformis against ethanol-induced gastric damage in mice
Seaweeds are the most abundant source of polysaccharides such as alginates and agar, as well as carrageenans. This study aimed to investigate the gastroprotective activity and the mechanism underlying this activity of a sulfated-polysaccharide fraction extracted from the algae Hypnea musciformis (Wulfen) J.V. Lamour. (Gigartinales-Rhodophyta). Mice were trea
Rev. bras. farmacogn.. Publicado em: 01/02/2013
-
21. Atividade antinociceptiva e anti-inflamatória do sesquiterpeno nerolidol em camundongos. / Antinociceptive and anti-inflammatory activities of the sesquiterpeno nerolidol in mice.
Nerolidol, an acyclic sesquiterpene found as the major component in several essential oils, has antineoplastic, antimicrobial and antileishmanial activities, however its action in painful processes has never been studied. This study investigated the antinociceptive and anti-inflammatory activities of nerolidol in experimental pain and inflammation models in
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 06/12/2012
-
22. Ação do inibidor da enzima dipeptidil peptidase 4 sobre o pré-condicionamento isquêmico em pacientes portadores de diabetes mellitus tipo 2 e doença arterial coronariana estável / Effect of dipeptidyl peptidase-4 enzyme inhibitor on ischemic preconditioning in patients with type 2 diabetes and symptomatic coronary artery disease
Ischemic preconditioning (IPC) refers to the phenomenon in which short periods of myocardial ischemia and reperfusion promote resistance to a subsequent prolonged ischemic insult. Some hypoglycemic drugs, such as glibenclamide and repaglinide, are able to inhibit this protective phenomenon probably by its effects as blockers of adenosine triphosphate-depende
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 19/10/2012
-
23. Eficácia da sitagliptina no controle glicêmico e na função cardiovascular de pacientes portadores de diabetes mellitus tipo 2 tratados com metformina e glibenclamida / Efficacy of sitagliptin on glycemic control and cardiovascular function in patients with type 2 diabetes mellitus treated with metformin and glibenclamide
No tratamento do diabetes mellitus tipo 2, busca-se a otimização do controle glicêmico para evitar as complicações da doença. Quando a combinação mais utilizada (sulfoniluréia e biguanida) falha em manter o controle glicêmico, um terceiro agente é associado, podendo ser a insulina ou outro hipoglicemiante oral. O objetivo deste estudo foi comparar
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 11/07/2012
-
24. Participação dos canais de potássio no efeito relaxante do ácido ent-7a-hidroxitraquiloban-18-oico em traqueia isolada de cobaia / Participation of potassium channels in the ent-7a-hidroxitrachyloban-18-oic acid relaxation effect on guinea pig trachea
From Xylopia langsdorfiana A. St-Hil. &Tul. stem bark was isolated the diterpene of trachylobane class, ent-7α-hydroxytrachyloban-18-oic acid (trachylobane-318) that in previous studies showed to be able to relax guinea-pig trachea pre-contracted by carbachol (CCh). Thus, we aimed to investigate the action mechanism underlying in this trachylobane-318 r
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 17/02/2012