Genetic Promoter Regions
Mostrando 1-12 de 222 artigos, teses e dissertações.
-
1. Polymorphisms in the heme oxygenase-1 and bone morphogenetic protein receptor type 1b genes and estimated glomerular filtration rate in Brazilian sickle cell anemia patients
ABSTRACT Introduction Mutations affecting genes involved in oxidative and signaling pathways may be associated with kidney disease in sickle cell anemia. We determined the allele and genotype frequencies of some polymorphisms in the promoter regions of the Heme Oxygenase-1 (HMOX1) [rs2071746 (A > T) and (GT)n repeats, short (S) and long (L) alleles] and Bon
Hematol., Transfus. Cell Ther.. Publicado em: 2021-06
-
2. Genetic characterisation of Langerin gene in human immunodeficiency virus-1-infected women from Bahia, Brazil
Studies on human genetic variations are a useful source of knowledge about human immunodeficiency virus (HIV)-1 infection. The Langerin protein, found at the surface of Langerhans cells, has an important protective role in HIV-1 infection. Differences in Langerin function due to host genetic factors could influence susceptibility to HIV-1 infection. To verif
Mem. Inst. Oswaldo Cruz. Publicado em: 2014-04
-
3. Prospecção de SNPs por eletroforese capilar e sua identificação em genes candidatos relacionados à resistência de caprinos a nematóides gastrintestinais / Prospection of SNP by capillary electrophoresis related to resistance to gastrointestinal infection by nematodes in goats
The cytokines are small cell-signaling proteins that play important role in immunologic system acting in intracellular communication. Five genes from cytokine family, i.e., IL2, IL4, IL13, IFNg, and TNFa were selected to search for SNPs, which may be associated with goat gastrointestinal endoparasites resistance. A population of 229 goats was produced in Emb
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/04/2012
-
4. Clinical and molecular analysis of the enamelin gene ENAM in Colombian families with autosomal dominant amelogenesis imperfecta
In this study, we analyzed the phenotype, clinical characteristics and presence of mutations in the enamelin gene ENAM in five Colombian families with autosomal dominant amelogenesis imperfecta (ADAI). 22 individuals (15 affected and seven unaffected) belonging to five Colombian families with ADAI and eight individuals (three affected and five unaffected) be
Genetics and Molecular Biology. Publicado em: 2012
-
5. Redundancy and recombination in the Echinococcus AgB multigene family : is there any similarity with protozoan contigency genes?
Numerous genetic variants of the Echinococcus antigen B (AgB) are encountered within a single metacestode. This could be a reflection of gene redundancy or the result of a somatic hypermutation process. We evaluate the complexity of the AgB multigene family by characterizing the upstream promoter regions of the 4 already known genes (EgAgB1-EgAgB4) and evalu
Publicado em: 2011
-
6. Promoter region sequence differences in the A and G gamma globin genes of Brazilian sickle cell anemia patients
Fetal hemoglobin (HbF), encoded by the HBG2 and HBG1 genes, is the best-known genetic modulator of sickle cell anemia, varying dramatically in concentration in the blood of these patients. This variation is partially associated with polymorphisms located in the promoter region of the HBG2 and HBG1 genes. In order to explore known and unknown polymorphisms in
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-08
-
7. Análise estrutural e funcional da região promotora de rDNA de Leishmania (Viannia) braziliensis e estudo comparativo com as regiões de Leishmania (Leishmania) / Structural and functional caracterization of rDNA promoter region of Leishmania (Viannia) braziliensis and comparative study with the Leishmania (Leishmania) region
Leishmaniasis is the generic name of a serious public health problem that is caused by protozoa of the genus Leishmania. In its lifecycle, the parasite has two hosts, a vertebrate and an invertebrate. The genus Leishmania is divided into two subgenera: Leishmania (Leishmania) and Leishmania (Vianna), according to the position occupied by the promastigotes fo
Publicado em: 2009
-
8. Expression of human respiratory syncytial virus N and P proteins: functional and immunization studies. / Expressão das proteínas N e P do vírus respiratório sincicial humano: estudos funcionais e de imunização.
The Human Respiratory Syncytial Virus is a single stranded negative RNA enveloped virus and it is considered the most important pathogen of the respiratory tract of infants and neonates. The viral N and P proteins were expressed in bacteria, purified and used for the production of polyclonal antibodies in mice. In silico studies allowed the prediction of int
Publicado em: 2009
-
9. Polimorfismos dos genes HLA e regiões promotoras do TNF- alfa -238 e -308 como fatores de sucetibilidade a psoriase e gravidade da doença / HLA and TNF-Alpha promoter regions -238 and -308 polymorphisms and marks of susceptibility to psoriasis and severety of the disease
Psoriasis is an erythematous, scaly inflammatory dermatosis with a complex immunologic basis. The strongest genetic marker for psoriasis is HLA-Cw*06. Polymorphisms in the TNF-a promoter region, especially replacement of guanine with adenine in positions -238 and -308 are related to higher TNF-a production and higher risk for psoriasis in Caucasoid populatio
Publicado em: 2009
-
10. Characterization of chitinase gene from lutzomyia longipalpis:alternative splicing description and search for promoter sequence / Caracterização de gene de quitinase de Lutzomyia longipalpis: descrição de processamento alternativo e busca por seqüência promotora
Leishmaniasis is a disease caused by Leishmania protozoa transmitted by the bite of infected sand flies. Current methods used to combat this illness have been shown to be inefficient, and better knowledge of aspects related to Leishmania-sand fly interaction are necessary for the development of new controlling methods. A cDNA codifying for a midgutspecific c
Publicado em: 2009
-
11. Transformação genética de abobrinha-de-moita e melancia para resistência ao Papaya ringspot virus - type Watermelon e ao Zucchini yellow mosaic virus / Genetic transformation of zucchini squash and watermelon for resistance to Papaya ringspot virus - type W and Zucchini yellow mosaic virus
Diseases caused by the potyviruses Papaya ringspot virus - type Watermelon (PRSV-W) and Zucchini yellow mosaic virus (ZYMV) significantly reduce the yield and fruit quality of zucchini squash (Cucurbita pepo), watermelon (Citrullus lanatus), as well as other cucurbit crops in Brazil. The purpose of this work was to obtain zucchini squash and watermelon trans
Publicado em: 2009
-
12. Estudo molecular em individuos com surdez sensorioneural não-sindromica monoalelicos para mutações no gene GJB2 / Molecular study in subjects with sensorineural nonsyndromic deafness and monoallelics mutations in GJB2 gene
Mutations in the GJB2 gene (Cx26) are the most common cause of autosomal recessive nonsyndromic hearing loss. However, in 10 to 40% of these cases, mutations in Cx26 gene are detected in on1y one allele which causes a problem in molecular diagnostico These findings could be attributed to the existence of mutations in non-coding regions of the gene or mutatio
Publicado em: 2009