Genetic Predisposition To Disease
Mostrando 37-48 de 106 artigos, teses e dissertações.
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37. Caracterização do polimorfismo dos alelos HLA de classe I e nos microssatelites do fator de necrose tumoral em pacientes brasileiros com psoriase vulgar
Introduction - Psoriasis is a genetic chronic inflammatory skin disorder with genes involved in disease predisposition located within the highly polymorphic Major Histocompatibility Complex (MHC) region on the chromosome 6p21.3. The goal of the present study was to identify, evaluate distribution and determine genetic associations of HLA class I genes and Tu
Publicado em: 2005
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38. Pathogenicity of Fusarium oxysporum f. sp. phaseoli, nitrogen fertilization and common bean yield. / Patogenicidade de Fusarium oxysporum f.sp. phaseoli, adubação nitrogenada e produtividade de feijão.
Brazil is one of the biggest world growers and consumers of common bean, that is one of the main protein sources in the feeding habits of the significantly population plot. Even if present prominence in the world common bean production, the Brazilian yield is very low. In the spring-summer 2002 the yield was about 926 kg.ha-1, a value much lower than the cro
Publicado em: 2005
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39. Schizophrenia: do men and women suffer from the same disease?
This article reviews the literature on normal brain development and behavioural development in men and women as well as on aetiological risk factors for schizophrenia, such as pre-, peri- and postnatal complications. The male-female comparisons of age and type of onset, symptomatology, course and outcome were based on a population-based sample of 232 first i
Archives of Clinical Psychiatry (São Paulo). Publicado em: 2002
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40. Adrenocortical tumors in children
Childhood adrenocortical tumors (ACT) are rare. In the USA, only about 25 new cases occur each year. In Southern Brazil, however, approximately 10 times that many cases are diagnosed each year. Most cases occur in the contiguous states of São Paulo and Paraná. The cause of this higher rate has not been identified. Familial genetic predisposition to cancer
Brazilian Journal of Medical and Biological Research. Publicado em: 2000-10
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41. Parental Genotypes in the Risk of a Complex Disease
Our understanding of the genetic etiology of complex disorders is still elusive. According to the common-variant/common-disease hypothesis, frequent functional polymorphisms are the best candidates for disease-susceptibility alleles. Implicitly, we also assume that disease-susceptibility alleles are preferentially transmitted from parents to the affected off
The American Society of Human Genetics.
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42. Evidence for an Inherited Predisposition Contributing to the Risk for Rotator Cuff Disease
Background: A genetic predisposition has been suggested to contribute to the risk for development of rotator cuff disease on the basis of observed family clusters of close relatives. We used a population-based resource combining genealogical data for Utah with clinical diagnosis data from a large Utah hospital to test the hypothesis of excess familial cluste
Journal of Bone and Joint Surgery.
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43. Association of Genetic Variants with Chronic Kidney Disease in Japanese Individuals
Background and objectives: Although genetic linkage analyses and association studies have implicated several loci and candidate genes in predisposition to chronic kidney disease (CKD), the genes that underlie genetic susceptibility to this condition have remained uncharacterized. The purpose of the present study was to identify genetic variants that confer s
American Society of Nephrology.
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44. Moderate- to low-risk variant alleles of cutaneous malignancies and nevi: lessons from genome-wide association studies
Cutaneous malignancies, especially malignant melanoma, exhibit great genetic heterogeneity. As a result, some individuals and families have particularly increased risk due to genetic predisposition to the disease. The susceptibility alleles range from rarely occurring, heritable, high-risk variants to ubiquitously occurring low-risk variants. Although until
BioMed Central.
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45. Genetic variation in cancer predisposition: Mutational decay of a robust genetic control network
A computational model of cancer progression is used to study how mutations in genes that control tumor initiation and progression accumulate in populations. The model assumes that cancer occurs only after a cell lineage has progressed through a series of stages. The greater the number of stages, the more strongly the individual is protected against cancer. I
National Academy of Sciences.
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46. Is there a genetic basis for Fuchs' heterochromic uveitis? Discordance in monozygotic twins.
One pair, and probably two pairs, of monozygotic twins are reported with discordance for Fuchs' heterochromic uveitis (FHU). Regular Mendelian inheritance of this disease is now proved to be impossible. The heritability of FHU is low and may be zero. The possibility of any genetic predisposition to the disease and its association with 'simple' heterochromia
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47. The genetics of chronic obstructive pulmonary disease
Chronic obstructive pulmonary disease (COPD) is a significant cause of global morbidity and mortality. Previous studies have shown that COPD aggregates in families, suggesting a genetic predisposition to airflow obstruction. Many candidate genes have been assessed, but the data are often conflicting. We review the genetic factors that predispose smokers to C
BioMed Central.
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48. Blood‐derived gene‐expression profiling in unravelling susceptibility to recessive disease
Identification of new disease predisposition genes with chip‐based technologies typically requires extensive financial and sample resources. We have recently shown that combining peripheral blood genome and transcriptome (BGT) information in highly selected materials can be a successful low‐cost approach to unravelling dominant tumour susceptibility. In
BMJ Group.