Genetic Predisposition To Disease
Mostrando 13-24 de 106 artigos, teses e dissertações.
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13. Multiple endocrine neoplasia type 2: achievements and current challenges
Incremental advances in medical technology, such as the development of sensitive hormonal assays for routine clinical care, are the drivers of medical progress. This principle is exemplified by the creation of the concept of multiple endocrine neoplasia type 2, encompassing medullary thyroid cancer, pheochromocytoma, and primary hyperparathyroidism, which di
Clinics. Publicado em: 2012
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14. Alterações metabólicas cerebrais associadas aos fatores de risco cardiovascular: um estudo de tomografia por emissão de pósitron (PET) / Abnormalities on brain metabolism associated to cardiovascular risk factors: a positron emission tomography (PET) study
INTRODUCTION: Cardiovascular risk factors (CVRF) are known to affect cerebral blood flow, possibly contributing to cognitive decline and to the emergence of Alzheimers disease (AD), the commonest form of dementia. Positron emission tomography (PET) with 18-fluoro-2-deoxyglucose (18FFDG) has been widely used to demonstrate specific patterns of reduced brain g
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 05/12/2011
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15. Differential expression analysis of ID2, PRELP and SMOC2 genes in ectopic and eutopic endometrium in women with and without endometriosis in the proliferative phase of the menstrual cycle. / Análise da expressão diferencial dos genes ID2, PRELP e SMOC2 em endométrio ectópico e eutópico de mulheres com e sem endometriose na fase proliferativa do ciclo menstrual
Endometriosis is a complex disease and its etiology is multifactorial, characterized by the presence of endometrial tissue outside the uterine cavity especially in the pelvic peritoneum and ovaries, involving genetic predisposition, environmental factors, anatomical, endocrine and immunological changes. It affects 10 to 15% of women of reproductive age and 3
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 07/10/2011
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16. Estudos dos polimorfismos dos genes GSTT1, GSTM1 e NINJURIN1 em indivíduos com Hanseníase.
A hanseníase é uma doença infecciosa crônica causada pelo bacilo álcool-ácido resistente Mycobacterium leprae (M. leprae), patógeno intracelular obrigatório, que afeta a pele e o sistema nervoso periférico. A expressão dessa doença resulta da interação entre o bacilo e o sistema imunológico; a maioria das pessoas infectadas desenvolve resposta
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 26/07/2011
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17. Polymorphisms associated with the risk of lung cancer in a healthy Mexican Mestizo population: application of the additive model for cancer
Lung cancer is the leading cause of cancer mortality in Mexico and worldwide. In the past decade, there has been an increase in the number of lung cancer cases in young people, which suggests an important role for genetic background in the etiology of this disease. In this study, we genetically characterized 16 polymorphisms in 12 low penetrance genes (AhR,
Genetics and Molecular Biology. Publicado em: 03/11/2011
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18. Insights into Alzheimer disease pathogenesis from studies in transgenic animal models
Alzheimer disease is the most common cause of dementia among the elderly, accounting for ~60-70% of all cases of dementia. The neuropathological hallmarks of Alzheimer disease are senile plaques (mainly containing p-amyloid peptide derived from amyloid precursor protein) and neurofibrillary tangles (containing hyperphosphorylated Tau protein), along with neu
Clinics. Publicado em: 2011
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19. Percepção de risco e comportamento em saúde de usuários com história pessoal de neoplasias em uma unidade de saúde da família / Risk perception and health behavior of users with personal history of neoplasm in a family health unit.
As neoplasias malignas figuram como a segunda causa de morte por doença no mundo todo, no Brasil, e no município de Ribeirão Preto. Políticas têm sido propostas na arena da saúde pública para o enfrentamento da problemática do câncer no país. De acordo com a Política Nacional de Atenção Oncológica, é no contexto da Atenção Básica à Saúde
Publicado em: 2011
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20. Risk perception for cancer and preventive behaviors in a sample of clients attending an outpatient cancer genetic counseling clinic / Percepção de risco para câncer e comportamentos preventivos em uma amostra de usuários de um ambulatório de aconselhamento genético oncológico
This study researched the perception of risk for developing cancer and preventive behaviors of individuals with suspect of hereditary cancer syndromes. It aimed to describe the perception of risk and causes of the main neoplasms related to hereditary cancer syndromes in a sample of users of a genetic counseling service for cancer; to associate behaviors adop
Publicado em: 2010
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21. Análise do gene AIP na acromegalia familial isolada / Analysis of the AIP gene in familial isolated acromegaly
Acromegaly is a rare disfigurating and insidious disease characterized by enlargement of hands, feet and skull bones due to excess of growth hormone (GH) secreted by a pituitary tumor (somatotropinoma). The majority of the cases with acromegaly is sporadic, however it may occur in association with inherited disorders as Multiple Endocrine Neoplasia type 1 (M
Publicado em: 2010
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22. Estudo da associação do polimorfismo genético em carcinomas da tiróide / Study on the association of genetic polymorphism in thyroid cancer
Thyroid nodules are common in clinical practice and the incidence of thyroid cancer is increasing throughout the world. Certainly, an important factor for the increase of the incidence is the use of ultrasound and PAFF. The identification of genetic polymosphism is important for understanding the potential mechanisms involved in thyroid carcinogenesis. We hy
Publicado em: 2010
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23. Analise da expressão do gene BRAF e suas possiveis implicações diagnosticas e prognosticas para pacientes portadores de carcinoma papilifero da tireoide / BRAF expression may help identify malignant nodules and define outcomes in papillary thyroid cancer patients
Background: Thyroid cancer is the most common endocrine malignancy, corresponding to 1% of all human neoplasms. Thyroid nodules are very frequent, mainly in women over 60 years. The relationship of BRAF gene with papillary thyroid tumorigenesis is well recognized in the literature. Its BRAFV600E mutation has been related to tumor aggressiveness and patients�
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 31/08/2009
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24. Polimorfismos genÃticos da mannose binding lectin em adolescentes com diabetes melito tipo 1
Type 1 diabetes is an autoimmune disease in which progressive destruction of pancreatic beta cells results in persistent hyperglycemia. Despite all the progress, the etiopathogenic mechanisms of this disease, is still not very well understood, which difficult the discovery of effective methods of prevention and cure. With the development of studies, several
Publicado em: 2009