Genes Neoplasm
Mostrando 13-24 de 41 artigos, teses e dissertações.
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13. Seleção e caracterização de peptídeos miméticos a proteínas tumorais no estadiamento clínico-patológico do câncer de próstata
Prostate cancer is the second cause of deaths by tumor in men, surpassed only to lung cancer. Currently, PSA (prostate-specific antigen) is clinical test of choice for PCa detection and treatment. However, the limitations of the PSA test such as large number of false positive results and unnecessary biopsies indicate the need for other means of screening for
Publicado em: 2010
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14. Expressão da COX-2 em carcinomas de mama intraductais e invasores e sua relação com a expressão de HER-2, p53 e receptores de estrógeno e progesterona / Expression of cyclooxygenase-2 and p53 inin situ and invasive regions of ductal adenocarcinoma of the breast
Introdução: evidências laboratoriais sugerem que a enzima ciclooxigenase-2 (COX-2), é um dos principais componentes da cascata inflamatória. A enzima é responsável pela conversão do ácido araquidônico em prostaglandinas e tromboxanos. Estudos sugerem que a expressão da COX-2 correlaciona-se diretamente com o potencial maligno dos tumores de mama,
Publicado em: 2010
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15. Investigation of clinical utility of ATM and PTEN genes in the differentiated thyroid cancer / Avaliação da utilidade clinica dos genes ATM e PTEN em cancer bem diferenciado da tireoide
In order to investigate the clinical utility of two tumor-suppressing genes involved in the control of cell proliferation and survival, we ve studied proteins ATM and PTEN through immunohistochemistry in 272 differentiated thyroid carcinoma diagnosed patients (142 classical papillary thyroid carcinomas type, 72 papillary thyroid carcinomas follicular variant
Publicado em: 2009
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16. Avaliação da expressão gênica da proteína 2 ligante de SH3 ativadora da GTPase de Ras (G3BP2), do fator da tecidual (TF) e da isoforma asHTF como possíveis marcadores prognósticos em carcinoma epidermóide de cabeça e pescoço / Evaluation of gene expression GTPase activating protein (SH3 domain) binding protein 2 (G3BP2), tissue factor (TF) and its isoform asHTF as possible prognostic markers in head and neck squamous cell carcinoma
GTPase activating protein (SH3 domain) binding protein 2 (G3BP2) seems to be involved in pathways important for cell survival as NF- B pathway. Tissue factor (TF) and its isoform asHTF appear to be involved in angiogenesis, proliferation and metastasis. Thus, the genes G3BP2, TF and asHTF seem possible prognostic factors in head and neck squamous cell carcin
Publicado em: 2009
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17. Minimal residual disease study in acute lymphoblastic leukemia of child and adolescent / Estudo de doença residual minima em leucemia linfoide aguda da criança e do adolescente
A leucemia linfóide aguda (LLA) é o câncer mais comum da infância. Os atuais protocolos de tratamento da LLA levam à cura em 70% dos casos e parte do sucesso se deve à aplicação de diferentes tratamentos para os pacientes estratificados em diferentes grupos de risco, segundo fatores prognóstico pré-tratamento (contagem leucocitária e idade ao diag
Publicado em: 2009
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18. Expression profiles of metastasis-related genes in a cohort of childhood and adult adrenocortical tumors / Perfis de expressão de genes relacionados a metástases em uma coorte de pacientes adultos e pediátricos portadores de neoplasias do córtex da supra-renal
Adrenocortical carcinoma (ACC) is a rare neoplasm with a poor prognosis. Although molecular studies have uncovered many aspects of ACC tumorigenesis, little is known about molecular pathways involved in metastatic spread. The objective of our study is to analyze the expression profile of metastasis-related genes in a cohort of metastatic and nonmetastatic ad
Publicado em: 2008
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19. Comparative analysis of normal adrenal cortice and adrenocortical carcinoma transcriptomes / Análise comparativa dos transcritomas do córtex adrenal normal e adenocarcinoma do córtex adrenal
A carcinogênese do córtex da supra-renal é um processo complexo que envolve alterações genéticas múltiplas e seqüenciais. Embora algumas dessas alterações já tenham sido caracterizadas, de modo geral estes mecanismos permanecem pouco compreendidos. Um conhecimento mais aprofundado dos mesmos não só levaria à descoberta de novos marcadores de pr
Publicado em: 2008
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20. Evaluation of polymorphisms of matrix metalloproteinases genes in prostate cancer / Avaliação de polimorfismos dos genes das metaloproteinases da matriz no câncer de próstata
Introduction: Prostate cancer (PCa) is the most frequent tumor in males in Brazil. Research has been directed for the identification of molecular markers that can predict the PCa predisposition and prognosis. Single nucleotide polymorphisms (SNPs) are genome variations, present in a frequency of 1% or more. The matrix metalloproteinases (MMPs) are a family o
Publicado em: 2008
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21. Alterations of E-cadherin and β-catenin genes in pleomorphic adenoma and adenoid cystic carcinoma: molecular and immunohistochemical study / Alterações nos genes da E-caderina e β-catenina em adenoma pleomórfico e carcinoma adenóide cístico: estudo molecular e imuno-histoquímico
Pleomorphic adenoma and adenoid cystic carcinoma represent a benign and malignant salivary gland neoplasm, respectively, that shares the same histological origin, however with distinct biological behavior. The aim of the present study was identify the -160 C/A polymorphism in the gene CDH1, mutational analysis of CTNNB1 gene and evaluation the expression of
Publicado em: 2008
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22. Análise de Polimorfismos de Nucleotídeos Únicos (SNPs) em pacientes com câncer de cabeça e pescoço.
Head and neck cancer is responsible for a high death rate. Single nucleotide polymorphisms (SNPs) are the most common variation of human genome and can be associated to the molecular basis of cancer. Objectives: To establish the incidence of this disease in the Otorhinolaryngology and Head and Neck Surgery Service of Hospital de Base in São José do Rio Pre
Publicado em: 2008
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23. Polimorfismos do gene TP53 no linfoma de Hodgkin / TP53 Gene Polymorphisms in Hodgkin Lymphoma
Hodgkin lymphoma is a hematololgic B neoplasm occurring at patients within any age, however more likely to affect those from 15 to 40 years-old. The TP53 gene is 20kb length gene with 11 exons that encodes the p53 protein, which main function is related to the conservation and integrity of the genetic code. Most cancers show point mutations in the TP53 seque
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 14/09/2007
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24. Molecular study of cellular adhesion genes in bladder cancer / Estudo molecular de genes envolvidos com adesão celular em câncer de bexiga
Introduction: Bladder cancer is the fifth neoplasm in Western countries, whose occurrence is 336,000 new cases annually, and also being responsible for 132,000 deaths in the worldwide. The incidence of bladder tumors in Brazil were 7,550 cases in 1999, representing 2,8% of overall diagnosed cancer in both gender. One of the main therapeutic challenges is ide
Publicado em: 2007