Gene Regulatory Network
Mostrando 1-12 de 194 artigos, teses e dissertações.
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1. Gene regulatory network inference and analysis of multidrug-resistant Pseudomonas aeruginosa
BACKGROUND Healthcare-associated infections caused by bacteria such as Pseudomonas aeruginosa are a major public health problem worldwide. Gene regulatory networks (GRN) computationally represent interactions among regulatory genes and their targets. They are an important approach to help understand bacterial behaviour and to provide novel ways of overcomi
Mem. Inst. Oswaldo Cruz. Publicado em: 05/08/2019
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2. Bioinformatics analysis of biomarkers and transcriptional factor motifs in Down syndrome
In this study, biomarkers and transcriptional factor motifs were identified in order to investigate the etiology and phenotypic severity of Down syndrome. GSE 1281, GSE 1611, and GSE 5390 were downloaded from the gene expression ominibus (GEO). A robust multiarray analysis (RMA) algorithm was applied to detect differentially expressed genes (DEGs). In order
Braz J Med Biol Res. Publicado em: 08/08/2014
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3. Expression analysis of miRNA and target mRNAs in esophageal cancer
We aimed to investigate miRNAs and related mRNAs through a network-based approach in order to learn the crucial role that they play in the biological processes of esophageal cancer. Esophageal squamous-cell carcinoma (ESCC) and adenocarcinoma (EAC)-related miRNA and gene expression data were downloaded from the Gene Expression Omnibus database, and different
Braz J Med Biol Res. Publicado em: 01/08/2014
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4. Dinâmica da Fermentação Alcóolica: Aplicação de Redes Booleanas na Dinâmica de Expressão Gênica em Linhagens de Saccharomyces Cerevisiae durante o Processo Fermentativo / Dynamics of alcoholic fermentation: application of Boolean networks in the dynamics of gene expression in Saccharomyces cerevisiae strains during fermentation process
Na busca por soluções que maximizem a produção de etanol, o melhoramento genético de diferentes linhagens de levedura tornou-se foco de investigação em diversos centros de pesquisa. Com o recente sequenciamento de uma linhagem selvagem utilizada nas usinas sucroalcooleiras brasileiras, a linhagem PE-2 da espécie Saccharomyces cerevisiae, surgiu o int
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 17/10/2012
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5. Redes complexas de expressão gênica: síntese, identificação, análise e aplicações / Gene expression complex networks: synthesis, identification, analysis and applications
Os avanços na pesquisa em biologia molecular e bioquímica permitiram o desenvolvimento de técnicas capazes de extrair informações moleculares de milhares de genes simultaneamente, como DNA Microarrays, SAGE e, mais recentemente RNA-Seq, gerando um volume massivo de dados biológicos. O mapeamento dos níveis de transcrição dos genes em larga escala é
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 21/02/2011
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6. Canalização: fenótipos robustos como consequência de características da rede de regulação gênica / Canalization: phenotype robustness as consequence of characteristics of the gene regulatory network
Em sistemas biológicos, o estudo da estabilidade das redes de regulação gênica é visto como uma contribuição importante que a Matemática pode proporcionar a pesquisas sobre câncer e outras doenças genéticas. Neste trabalho, utilizamos o conceito de ``canalizaçãocomo sinônimo de estabilidade em uma rede biológica. Como as características de um
Publicado em: 2011
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7. Worldwide genetic variation at the 3´-UTR region of the LDLR gene : possible influence of natural selection
The low density lipoprotein receptor gene (LDLR) contains many Alu insertions, and is especially Alu-rich at its 3 -untranslated region (3 -UTR). Previous studies suggested that the LDLR 3 -UTR could regulate gene expression by the stabilization of its mRNA. Given the faster Alu evolutionary rate, and wondering about its consequences in a possibly regulatory
Publicado em: 2011
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8. Análise da via de regulação gênica do miRNA156/SPL na brotação lateral e caracterização molecular do processo de emergência da gema axilar de cana de açucar / Analysis of the role(s) of the miRNA156/SPL pathway on branching/tillering and molecular characterization of sugarcane lateral bud outgrowth
Sugarcane is an economically important biofuel crop that recently has become a target for improvement of sustainable biomaterial production due to its high biomass productivity and built-in containment features. Therefore, studies aiming to improve the production of biomass per area are among the most important issues in sugarcane production. Plant biomass i
Publicado em: 2011
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9. Feature selection and intrinsically multivariate prediction in gene regulatory networks identification / Seleção de características e predição intrinsecamente multivariada em identificação de redes de regulação gênica
Feature selection is a crucial topic in pattern recognition applications, especially in bioinformatics, where problems usually involve data with a large number of variables and small number of observations. The present work addresses feature selection aspects in the problem of gene regulatory network identification from expression profiles. Particularly, we
Publicado em: 2008
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10. A genetic framework for flowering-time pathways in Citrus spp.
Floral transition is one the most drastic changes occurring during the life cycle of a plant. The shoot apical meristem switches from the production of leaves with associated secondary shoot meristems to the production of flower meristems. This transition is abrupt and generally irreversible, suggesting it is regulated by a robust gene regulatory network cap
Genetics and Molecular Biology. Publicado em: 2007
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11. Recurrent neural nets for networks inference of gene interactions using Markov chains / Redes neurais recorrentes para inferência de redes de interação gênica utilizando cadeias de Markov
Array technologies have made it strainghtforward to simultaneously monitor the expression pattern of thousands of genes. Thus, a lot fot data is being generated and the challenge now is to discover how to extract useful information from these data sets. Microarray data is highly specialized. It involves several variables in a nonlinear and temporal way, dema
Publicado em: 2007
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12. Redes bayesianas para inferÃncia de redes regulatÃrias de genes
With the development of functional genomics, data on a great number of species are being obtained in huge volumes. Technologies to measure the differences of the gene expression, through mRNA concentration (microarray), have become extremely popular, and their costs are decreasing. The reconstruction of genetic networks from gene expression data to study the
Publicado em: 2005