Gene Expression Profiling
Mostrando 25-36 de 507 artigos, teses e dissertações.
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25. Molecular cloning and expression profiling of a chalcone synthase gene from hairy root cultures of Scutellaria viscidula Bunge
A cDNA encoding chalcone synthase (CHS), the key enzyme in flavonoid biosynthesis, was isolated from hairy root cultures of Scutellaria viscidula Bunge by rapid amplification of cDNA ends (RACE). The full-length cDNA of S. viscidula CHS, designated as Svchs (GenBank accession no. EU386767), was 1649 bp with a 1170 bp open reading frame (ORF) that corresponde
Genetics and Molecular Biology. Publicado em: 23/04/2010
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26. Perfil de expressão gênica de fibroblastos associados ao câncer de mama submetidos ao tratamento com vitamina D / Gene expression profiling of breast carcinoma associated fibroblast following treatment with vitamin D
O Papel da 1,25(OH)2D3 (VD3) ou calcitriol, o metabolito ativo da Vitamina D, em câncer de mama tem sido extremamente explorado. Os efeitos antiproliferativos, prodiferenciativos e antiinflamatórios da VD3 são bem documentados na literatura. Análises de microarray vêm auxiliando a identificação de vários genes responsivos e modulados pela VD3 e seus
Publicado em: 2010
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27. Resposta molecular do endotélio pulmonar à exposição aguda de material particulado fino / Molecular response of pulmonary endothelial cells to acute exposure to fine particulate matter
Epidemiological studies establish a clear association between air pollution and increased cardiovascular and respiratory morbidity and mortality. However, the molecular mechanisms underlying the effect of fine particulate matter (PM2,5) are still poorly understood. The aim of this study was to characterize the impact of exposure to PM2,5 on the biology of pu
Publicado em: 2010
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28. Análise do perfil transcricional de células dendríticas derivadas de monócitos utilizadas na vacina terapêutica anti-HIV-1 / Transcription profile of monocyte derived dendritic cells used in therapeutic HIV-1 vaccine model
Aplicando tecnologia de microarray, objetivamos traçar o perfil do programa de maturação das Mo-DC pulsadas com HIV autólogo inativado por AT-2, a fim de identificar marcadores específicos de ativação funcional e sugerir um perfil de expressão de genes úteis na identificação de respostas ao modelo in vitro das Mo-vacina DC. Essas informações pod
Publicado em: 2010
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29. Differential gene expression profiles of hepatocellular carcinomas associated or not with viral infection
Chronic hepatitis B (HBV) and C (HCV) virus infections are the most important factors associated with hepatocellular carcinoma (HCC), but tumor prognosis remains poor due to the lack of diagnostic biomarkers. In order to identify novel diagnostic markers and therapeutic targets, the gene expression profile associated with viral and non-viral HCC was assessed
Brazilian Journal of Medical and Biological Research. Publicado em: 06/11/2009
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30. Gene expression analysis in sweet orange in response to Xanthomonas axonopodis pv. citri and Xanthomonas axonopodis pv. aurantifolii / Expressão diferencial de genes de laranja doce em resposta a infecção por Xanthomonas axonopodis pv. citri e axonopodis pv. aurantifolii
The most aggressive form of the citrus canker disease is caused by the bacteria Xanthomonas axonopodis pv. citri (Xac), which can infect all commercial varieties or species of citrus. In addition to Xac, Xanthomonas axonopodis pv. aurantifolii (Xaa) causes a weaker form of the disease, known as cancrose C, which is restricted to Mexican Lime (Citrus aurantif
Publicado em: 2008
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31. Influence of malignant mammary epithelial cells in gene expression of stromal cells from involved or uninvolved lymph nodes from breast cancer patients / Influência de células epiteliais mamárias malignas na expressão gênica de células estromais originárias de linfonodo axilar comprometido ou não comprometido de pacientes com câncer de mama
O desenvolvimento da metástase depende, entre outros fatores de um microambiente propício e é possível que as células do câncer de mama influenciem o perfil da expressão gênica das células estromais, tanto no tumor primário como no linfonodo regional. Para estudar este último evento obtivemos fibroblastos de linfonodos comprometidos (n=3) ou não
Publicado em: 2008
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32. Evaluation of gene expression profiling in a mouse model of L-gulonolactone oxidase gene deficiency
Humans and guinea pigs are species which are unable to synthesize ascorbic acid (vitamin C) because, unlike rodents, they lack the enzyme L-gulonolactone oxidase (Gulo). Although the phenotype of lacking vitamin C in humans, named scurvy, has long been well known, information on the impact of lacking Gulo on the gene expression profiles of different tissues
Genetics and Molecular Biology. Publicado em: 2007-03
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33. Citrus plastid-related gene profiling based on expressed sequence tag analyses
Plastid-related sequences, derived from putative nuclear or plastome genes, were searched in a large collection of expressed sequence tags (ESTs) and genomic sequences from the Citrus Biotechnology initiative in Brazil. The identified putative Citrus chloroplast gene sequences were compared to those from Arabidopsis, Eucalyptus and Pinus. Differential expres
Genetics and Molecular Biology. Publicado em: 2007
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34. Characterization of gene expresiion of tumoral cells in patients with sporadic colon adenocarcinoma / Caracterização da expressão genica de celulas tumorais de pacientes com adenocarcinoma esporadico do colon
The molecular mechanisms involved in sporadic colon adenocarcinoma (SCA) are still not completely elucidated. Recently, the serial analysis of gene expression (SAGE) method has allowed the global analysis of genes expressed in diverse cellular types but there are no studies in purified epithelial cells of SCA moderately differenciated. We have characterized
Publicado em: 2007
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35. Análise do transcriptoma durante a ontogenia do timo. / Analysis of the transcriptoma during the antogenia of the thymus.
The thymus is a complex organ structured by a stroma, which is formed mainly by cortical epithelial cells (cTECs) and medullary epithelial cells (mTECs) besides of other cell types such as dendritic cells (DC), macrophages, B lymphocytes and fibroblasts. Moreover, the T cell precursors arising from the bone marrow reach the thymus (thymocytes) maturing in T
Publicado em: 2007
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36. Expressão gênica diferencial de fibroblastos de linfonodos comprometidos ou não comprometidos de pacientes com câncer de mama após cultura isolada ou co-cultura com células epiteliais mamárias normais ou malignas / Differential gene expression of fibroblasts from involved or uninvolved lymph nodes from breast cancer patients cultured alone or cocultured with normal or malignant mammary epithelial cells
Tumor development may be influenced by epithelial-mesenchimal interactions in the primary site as well as in the involved lymph node from breast cancer patients. Our aim was to evaluate the proliferation rate and gene profile of fibroblasts obtained from involved and uninvolved lymph nodes from breast câncer patients and to determine the influence of normal
Publicado em: 2007