Gene Dosage
Mostrando 13-24 de 741 artigos, teses e dissertações.
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13. Polimorfismo -174g>C do gene de Interleucina-6 da Tuberculose Pulmonar / Interleukin-6-174g>c polymorphism gene in pulmonary tuberculosis
O objetivo do estudo foi investigar o perfil de produÃÃo de IL-6 em pacientes com tuberculose pulmonar ativa e avaliar o papel funcional do polimorfismo -174G>C do gene de IL-6 na produÃÃo sistÃmica desta citocina. Um total de 63 pacientes e 99 controles foi estudado, sendo 38 pacientes [25(65,8%) masculinos] e 63 controles [51 (81%) masculinos] para a
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 07/05/2009
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14. Influência da distrofia muscular do Golden Retriever (GRMD) na viabilidade espermática e nas características morfológicas do aparelho reprodutivo masculino / Influence of Golden Retriever muscular dystrophy (GRMD) on sperm viability and on morphologic characteristics of the male reproductive tract
Muscular dystrophies constitute a group of diseases characterized by progressive and irreversible muscle degeneration. Duchenne´s Muscular Dystrophy (DMD) is a lethal myopathy caused by dystrophin deficiency, a muscular cell cytoskeleton protein. The dystrophin gene have recessive characteristic and is located in the p21 portion of the X chromosome. Advance
Publicado em: 2009
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15. Efficacy of HUMN criteria for scoring the micronucleus assay in human lymphocytes exposed to a low concentration of p,p'-DDT
The cytokinesis-block micronucleus (CBMN) assay is one of the standard cytogenetic tools employed to assess chromosomal damage subsequent to exposure to genotoxic/cytotoxic agents, and is widely applicable to plant, animal and human cells. In the present study, the CBMN assay was used to assess the baseline damage in binuclear human peripheral blood lymphocy
Brazilian Journal of Medical and Biological Research. Publicado em: 31/05/2008
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16. Duffy gene polymorphism study in patients with malignant hypertension and blood donors / Estudo dos polimorfismos do gene DUFFY em pacientes com hipertensão maligna e doadores de sangue
Essential hypertension has a high prevalence worldwide and the has genetic and environment causes. Searching genetics correlation for hypertension, a potential role of DARC (Duffy Antigen Receptor of Chemokines) was described as an Interleukine-8 receptor in endothelium and that this interaction might contribute for the pathogenesis of pre-eclampsia. DARC is
Publicado em: 2008
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17. Análise funcional dos genes Xist e DNMT1 na manutenção do processo de inativação do cromossomo X humano através do silenciamento gênico por RNAi / Functional analysis of XIST and DNMT1 genes in the maintenance of X chromosome inactivation process in human through gene silencing by RNAi
X chromosome inactivation (XCI) is the phenomenon through which one of the X chromosomes in female mammals is silenced to achieve dosage compensation related to males. It involves the expression of XIST gene exclusively from the inactive X, and the association of its RNA in cis in this chromosome. This leads to a series of epigenetic modifications in the chr
Publicado em: 2008
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18. Expression of IGF-II, IGF-IR, SF-1 and DAX-1 genes in pediatric and adult adrenocortical tumors / Expressão dos genes IGF-II, IGF-IR, SF-1 e DAX-1 em tumores adrenocorticais de crianças e adultos
Introduction: The molecular pathogenesis of adrenocortical tumors is heterogeneous and incompletely understood. Insulin-like growth factor II (IGF-II) overexpression has been demonstrated in adult adrenocortical carcinomas. IGF-II exerts its mitogenic effects through interaction with IGF-I receptor (IGF-IR). In addition, steroidogenic factor 1 gene (SF-1) an
Publicado em: 2008
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19. Cupriuresis in parents of patients with Wilson disease before and after oral intake of d-penicillamine / Cuprúria em pais de pacientes com doença de Wilson antes e depois da administração oral de d-penicilamina
Wilson disease is a biliary copper excretion disturbance, of recessive autossomic heritage, due to ATP7B gene mutations. The copper not bound to apoceruloplasmin circulates in the organism bound to amino acids and accumulates mainly in the liver and brain being excreted by the kidneys. Urinary copper higher than 100ug/24h can be useful in the diagnosis, but
Publicado em: 2007
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20. Gene therapy of advanced-stage head and neck squamous cell carcinoma with Mycobacterium leprae heat shock protein 65 DNA: a phase 1 study / Fase 1 do estudo da aplicação da vacina de DNA HSP 65 (Heat Shock Protein) do Mycobacterium leprae no tratamento de formas avançadas de carcinomas epidermóide de cabeça e pescoço
This study goal was to describe and graduate the local and systemic toxicity of intratumoral injections of HSP (Heat Shock Protein) 65 DNA vaccine in advanced-stage head and neck squamous cell carcinoma (SCCHN) patients and to define the highest well tolerated dose for them. This is a prospective, non-randomized, uncontrolled, phase 1 study, using a new vacc
Publicado em: 2007
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21. Factor evaluations associated to in vitro regeneration of five cultivars of cassava / Avaliação de fatores associados à regeneração in vitro e transformação genético de cinco cultivares de mandioca
Cassava (Manihot esculenta Crantz) is one of the most important crops for human consumption. It is considered the fourth most important source of carbohydrates in the tropics. The increasing importance of the culture achieved during the last years, raised the interest in the improvement and development of new cassava varieties. Therefore, the aims of the pre
Publicado em: 2007
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22. Avaliação da expressão do mRNA do GLUT 4 em corpo lúteo de cadelas sadias ao longo do diestro / Evaluation of the expression of GLUT4 mRNA in canine corpus luteum during diestrus
The canine estral cycle differs from other domestic species. Some studies demonstrated that the increase of the plasmatic concentration of progesterone during canine luteinic phase can lead to metabolic alterations, such as insulinic resistance and may cause complications such as Diabetes mellitus. Glucose is a molecule that is transported in most cells by t
Publicado em: 2006
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23. Mutations in the SRY, DAX1, SF1 and WNT4 genes in Brazilian sex-reversed patients
In most mammals, male development is triggered by the transient expression of the SRY gene, which initiates a cascade of gene interactions ultimately leading to the formation of a testis from the indifferent fetal gonad. Mutation studies have identified several genes essential for early gonadal development. We report here a molecular study of the SRY, DAX1,
Brazilian Journal of Medical and Biological Research. Publicado em: 2004-01
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24. Animal models for human contiguous gene syndromes and other genomic disorders
Genomic disorders refer to a group of syndromes caused by DNA rearrangements, such as deletions and duplications, which result in an alteration of normal gene dosage. The chromosomal rearrangements are usually relatively small and often difficult to detect cytogenetically. In a subset of such conditions the rearrangements comprise multiple unrelated contiguo
Genetics and Molecular Biology. Publicado em: 2004