Gene Delivery
Mostrando 13-24 de 834 artigos, teses e dissertações.
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13. Desenvolvimento e caracterização de sistemas de liberação tópica a base de cristais líquidos para veiculação de siRNA na terapia gênica / Development and characterization of topical delivery systems based on liquid crystals for siRNA in gene therapy
A terapia gênica por interferência de RNA (RNAi) trata-se de um processo de silenciamento pós-transcricional capaz de suprimir a expressão de um determinado gene. A RNAi é uma proposta terapêutica promissora para o tratamento de muitas doenças severas que ainda não possuem cura ou terapias bem definidas. Porém, é necessário o desenvolvimento de si
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 10/05/2012
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14. Effects of high-intensity intermittent training on carnitine palmitoyl transferase activity in the gastrocnemius muscle of rats
We examined the capacity of high-intensity intermittent training (HI-IT) to facilitate the delivery of lipids to enzymes responsible for oxidation, a task performed by the carnitine palmitoyl transferase (CPT) system in the rat gastrocnemius muscle. Male adult Wistar rats (160-250 g) were randomly distributed into 3 groups: sedentary (Sed, N = 5), HI-IT (N =
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-08
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15. Desenvolvimento e avaliação imunológica de Nanotubos de Carbono funcionalizados com a proteína de envelope de Dengue virus 3
In terms of epidemiologic impact, Dengue (DENV) infections represent the most important infectious disease in Brazil. Consequently, the development of an efficient vaccine is considered a high priority. Due to this fact, many studies are being developed towards this goal, but no vaccine is currently available to the population. Carbon Nanotubes (CNT) have be
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 23/02/2011
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16. A role for adeno-associated viral vectors in gene therapy
Gene therapy constitutes a therapeutic intervention based on modification of the genetic material of living cells, by correcting genetic defects or overexpressing therapeutic proteins. The success of gene therapy protocols depends on the availability of therapeutically suitable genes, appropriate gene delivery systems and proof of safety and efficacy. Recent
Publicado em: 2010
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17. An effective device for generating alginate microcapsules
An alternative approach to somatic gene therapy is to deliver the therapeutic protein by implanting genetically modified cells that could overexpress the gene of interest. Microencapsulation devices were designed to protect cells from host rejection and prevent the foreign cells from spreading while allowing protein secretion. Alginate microcapsules form a s
Publicado em: 2010
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18. The RNA interference revolution
The discovery of double-stranded RNA-mediated gene silencing has rapidly led to its use as a method of choice for blocking a gene, and has turned it into one of the most discussed topics in cell biology. Although still in its infancy, the field of RNA interference has already produced a vast array of results, mainly in Caenorhabditis elegans, but recently al
Publicado em: 2010
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19. Hidróxidos duplos lamelares: nanopartículas inorgânicas para armazenamento e liberação de espécies de interesse biológico e terapêutico
Studies about the inorganic nanoparticles applying for non-viral release of biological and therapeutic species have been intensified nowadays. This work reviews the preparation strategies and application of layered double hydroxides (LDH) as carriers for storing, carrying and control delivery of intercalated species as drugs and DNA for gene therapy. LDH sho
Química Nova. Publicado em: 2010
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20. Trombofilias maternas hereditárias com e sem tromboembolismo venoso: resultados maternos e neonatais / Maternal inherited thrombophilias with or without venous thromboembolism: maternal and neonatal outcomes
The aim of this study was to evaluate differences in maternal and neonatal outcomes in pregnancies complicated by inherited thrombophilias between patients with and without venous thromboembolism. Despite increasing evidence in the literature indicating an association between inherited thrombophilias and adverse obstetric outcomes, doubts remain whether thro
Publicado em: 2010
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21. HSV-1-derived amplicon vectors: recent technological improvements and remaining difficulties - a review
Amplicons are defective and non-integrative vectors derived from herpes simplex virus type 1. As the vector genome carries no virus genes, amplicons are both non-toxic for the infected cells and non-pathogenic for the inoculated organisms. In addition, the large transgenic capacity of amplicons, which allow delivery of up to 150 Kbp of foreign DNA, makes the
Memórias do Instituto Oswaldo Cruz. Publicado em: 2009-05
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22. Associação entre polimorfismos do gene do receptor alfa de estrogênio com a densidade mamográfica em mulheres após a menopausa. / Estrogen alpha receptor gene polymorphisms association with mammographic density in postmenopausal women.
Introduction: Genes that encode proteins involved at biosynthesis, action and metabolism of sexual steroids are polymorphics. This condition could explain individual variations in mammographic density. The objectives of this study were to evaluate a possible association of clinical characteristics and polymorphisms HaeIII, MspI and XbaI of the estrogen recep
Publicado em: 2009
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23. A role for adeno-associated viral vectors in gene therapy
Gene therapy constitutes a therapeutic intervention based on modification of the genetic material of living cells, by correcting genetic defects or overexpressing therapeutic proteins. The success of gene therapy protocols depends on the availability of therapeutically suitable genes, appropriate gene delivery systems and proof of safety and efficacy. Recent
Genetics and Molecular Biology. Publicado em: 2008
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24. An effective device for generating alginate microcapsules
An alternative approach to somatic gene therapy is to deliver the therapeutic protein by implanting genetically modified cells that could overexpress the gene of interest. Microencapsulation devices were designed to protect cells from host rejection and prevent the foreign cells from spreading while allowing protein secretion. Alginate microcapsules form a s
Genetics and Molecular Biology. Publicado em: 2008