Trombofilias maternas hereditárias com e sem tromboembolismo venoso: resultados maternos e neonatais / Maternal inherited thrombophilias with or without venous thromboembolism: maternal and neonatal outcomes

AUTOR(ES)
DATA DE PUBLICAÇÃO

2010

RESUMO

The aim of this study was to evaluate differences in maternal and neonatal outcomes in pregnancies complicated by inherited thrombophilias between patients with and without venous thromboembolism. Despite increasing evidence in the literature indicating an association between inherited thrombophilias and adverse obstetric outcomes, doubts remain whether thrombophilic patients with venous thromboembolism present poorer maternal and neonatal outcomes than thrombophilic patients without venous thromboembolism. In this retrospective, observational and comparative study, 66 pregnant women with inherited thrombophilias, including 33 with venous thromboembolism and 36 without thromboembolism, were investigated. The main end-points analyzed were severe pre-eclampsia, placental abruption, fetal growth restriction, stillbirth, preterm delivery, and maternal hemorrhagic complications. The congenital thrombophilias included in this study were factor V Leiden (FVL), prothrombin G20210A mutation, C677T mutation in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene, protein S deficiency, protein C deficiency, and antithrombin deficiency. The two groups were similar in terms of population characteristics. The frequency of maternal and fetal/neonatal complications was similar in the two groups: severe pre-eclampsia (P=0.097), placental abruption (P=0.478), fetal growth restriction (P=0.868), stillbirth (P=0.359), preterm delivery (P=0.441), and maternal hemorrhagic complications (P=0.478). This study concluded that venous thromboembolism in thrombophilic patients does not worsen maternal or neonatal outcomes when compared to thrombophilic patients without venous thromboembolism.

ASSUNTO(S)

hemorrhage/complications mortalidade fetal antithrombin iii deficiency protein s proteína s tromboembolia venosa pré-eclâmpsia deficiência de antitrombina iii pre-eclampsia proteína c placental abruption preterm labor descolamento prematuro da placenta protein c trabalho de parto prematuro prothrombin/genetics protrombina/genética thrombophilia venous thromboembolism hemorragia/complicações trombofilia fetal mortality

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