Forced Swim
Mostrando 13-24 de 29 artigos, teses e dissertações.
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13. Contribution of the dopaminergic system to the effect of chronic fluoxetine in the rat forced swim test
Chronic administration of selective serotonin reuptake inhibitors (SSRI) enhances dopaminergic activity. However, the role of enhanced dopaminergic transmission in the therapeutic effects of this kind of antidepressants is still unclear. Drugs producing dopaminergic activation lead to an increment in general activity. Thus, it is reasonable to assume that so
Psychology & Neuroscience. Publicado em: 2008-06
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14. Avaliação da resposta inflamatória pulmonar e do transporte mucociliar em modelo de inflamação alérgica pulmonar: modulação pelo estresse induzido pela natação forçada / Evaluation of pulmonary inflammatory responses and mucociliary transport in a model of chronic allergic inflammation: modulation by stress induced by forced swimming
Background: It has increasing evidence linking the role of stress in the onset of asthma exacerbation and in the maintenance of asthmatic crises, as well as the importance of mucus production and the mucociliary clearance in the asthma physiopathology. Objectives: So, we consider relevant to evaluate in guinea pigs with pulmonary chronic allergic inflammatio
Publicado em: 2008
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15. Efeitos da administração prolongada do esteróide anabolizante decanoato de nandrolona em comportamentos emocionais e na expressão de genes relacionados ao sistema serotoninérgico em diferentes áreas cerebrais de camundongos / Effects of prolonged administration of the anabolic-androgenic steroid nandrolone decanoate in emotional behaviors and serotonergic system related genes expression in several brain areas of mice
Nandrolone decanoate is a highly abused anabolic-androgenic steroid (AAS) by individuals looking for gains in physical strength or body appearance. Supraphysiological doses of this testosterone synthetic derivative have been associated with many physical and psychiatric adverse effects, especially reported episodes of impulsiveness and overt aggressive behav
Publicado em: 2008
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16. Effect of Erythrina velutina and Erythrina mulungu in rats submitted to animal models of anxiety and depression
Erythrina velutina (EV) and Erythrina mulungu (EM), popularly used in Brazil as tranquilizing agents, were studied. The effects of acute and chronic oral treatment with a water:alcohol extract of EV (7:3, plant grounded stem bark; acute = 100, 200, 400 mg/kg; chronic = 50, 100, 200 mg/kg) were evaluated in rats (N = 11-12) submitted to the elevated T-maze (f
Brazilian Journal of Medical and Biological Research. Publicado em: 2006-02
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17. Evaluation of the effects of photooxidized Echis carinatus venom on learning, memory and stress
Snake venoms are a mixture of complex proteins, which have many physical and pharmacological properties. Photochemical detoxification has been suggested to generate photooxidized Echis carinatus venom product (POECVP). Antigenically-active photooxidized species of Echis carinatus venom could be obtained by exposing the venom to ultraviolet radiation (UVR) in
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2006
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18. Efeitos tardios do tratamento neonatal com sertralina sobre a depressÃo experimental induzida em ratos Wistar
The present study investigated the corporal weight, the experimental induced depression by forced swim and the exploratory behavior of young adult rats, treated in the neonatal period with sertraline, a selective serotonin reuptake inhibitor. According to the experiment treatment, two groups of suckling rats were distributed as follow way: A sertraline group
Publicado em: 2004
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19. Fertility of male adult rats submitted to forced swimming stress
We investigated whether stress interferes with fertility during adulthood. Male Wistar rats (weighing 220 g in the beginning of the experiment) were forced to swim for 3 min in water at 32ºC daily for 15 days. Stress was assessed by the hot-plate test after the last stressing session. To assess fertility, control and stressed males (N = 15 per group) were m
Brazilian Journal of Medical and Biological Research. Publicado em: 2003-05
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20. Galmic, a nonpeptide galanin receptor agonist, affects behaviors in seizure, pain, and forced-swim tests
The pharmacological exploitation of the galanin receptors as drug targets for treatment of epilepsy, depression, and pain has been hampered by the lack of workable compounds for medicinal chemists from random screening of large chemical libraries. The present work uses the tripeptidomimetic galnon and displays its presumed pharmacophores on a rigid molecular
National Academy of Sciences.
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21. Estrogen alters behavior and forebrain c-fos expression in ovariectomized rats subjected to the forced swim test
Estrogen has been implicated in brain functions related to affective state, including hormone-related affective disorders in women. Although some reports suggest that estrogen appears to decrease vulnerability to affective disorders in certain cases, the mechanisms involved are unknown. We used the forced swim test (FST), a paradigm used to test the efficacy
The National Academy of Sciences.
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22. Essential role of brain-derived neurotrophic factor in adult hippocampal function
Brain-derived neurotrophic factor (BDNF) regulates neuronal development and function. However, it has been difficult to discern its role in the adult brain in influencing complex behavior. Here, we use a recently developed inducible knockout system to show that deleting BDNF in broad forebrain regions of adult mice impairs hippocampal-dependent learning and
National Academy of Sciences.
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23. Serotonin receptor 1A knockout: An animal model of anxiety-related disorder
To investigate the contribution of individual serotonin (5-hydroxytryptamine; 5-HT) receptors to mood control, we have used homologous recombination to generate mice lacking specific serotonergic receptor subtypes. In the present report, we demonstrate that mice without 5-HT1A receptors display decreased exploratory activity and increased fear of aversive en
The National Academy of Sciences.
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24. Behavioral, neurochemical, and electrophysiological characterization of a genetic mouse model of depression
Depression is a multifactorial illness and genetic factors play a role in its etiology. The understanding of its physiopathology relies on the availability of experimental models potentially mimicking the disease. Here we describe a model built up by selective breeding of mice with strikingly different responses in the tail suspension test, a stress paradigm
The National Academy of Sciences.