Forced Swim
Mostrando 1-12 de 29 artigos, teses e dissertações.
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1. Effect of ethanol Adiantum capillus-veneris extract in experimental models of anxiety and depression
Depression is one of the most common psychiatric disorders with a prevalence of 15%-25%. Monoamine aminotransferases, in particular, norepinephrine, serotonin, and dopamine, change in the brain of depressed people. Adiantum capillus-veneris is one of the species of the maidenhair fern genus that have traditionally been used to treat cough, cold symptoms, and
Braz. J. Pharm. Sci.. Publicado em: 25/11/2019
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2. Baicalin ameliorates chronic mild stress-induced depression-like behaviors in mice and attenuates inflammatory cytokines and oxidative stress
The natural flavonoid glycoside baicalin (BA) produces a variety of pharmaceutical effects, particularly for psychiatric/neurological disorders. This study evaluated the behavioral and neuroprotective effects of BA in mice subjected to chronic unpredictable mild stress, a model of depression. BA (25 and 50 mg/kg) significantly increased sucrose consumption a
Braz J Med Biol Res. Publicado em: 19/06/2019
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3. Potential antidepressant effect of amantadine: a review of preclinical studies and clinical trials
Objective: Amantadine blocks N-methyl-D-aspartate (NMDA) receptors and has dopaminergic and noradrenergic action, a neurochemical profile that suggests its potential as an antidepressant drug. We conducted a systematic review of preclinical and clinical studies addressing the effects of amantadine in animal models of depression and in patients with depressi
Rev. Bras. Psiquiatr.. Publicado em: 11/06/2018
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4. Behavioural alterations are independent of sickness behaviour in chronic experimental Chagas disease
The existence of the nervous form of Chagas disease is a matter of discussion since Carlos Chagas described neurological disorders, learning and behavioural alterations in Trypanosoma cruzi-infected individuals. In most patients, the clinical manifestations of the acute phase, including neurological abnormalities, resolve spontaneously without apparent conse
Mem. Inst. Oswaldo Cruz. Publicado em: 11/12/2015
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5. Neonatal lipopolysaccharide exposure induces sexually dimorphic sickness behavior in adult rats
The aim of the present study was to evaluate whether neonatal exposure to lipopolysaccharide (LPS; 50 µg/kg, i.p., on postnatal day 2) induces depressive- and/or anxiety-like effects and sexually dimorphic responses in rats challenged with LPS (100 µg/kg, i.p.) in adulthood. The results revealed that males presented a less depressive state in the forced sw
Psychol. Neurosci.. Publicado em: 2014-06
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6. Evaluation of postpartum behaviour in rats treated with Hypericum perforatum during gestation
Gestational depression is detrimental to the health of the mother and the offspring and contributes to the appearance of depressive and anxiety symptoms during the postnatal period. Traditional antidepressants have undesirable side effects when utilised during gestation, but Hypericum perforatum has been characterised as an efficient and safe antidepressant
Rev. bras. farmacogn.. Publicado em: 2013-10
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7. Participação do sistema glutamatérgico do córtex pré-frontal medial ventral na modulação das consequências comportamentais do estresse de nado forçado / Participation of the glutamatergic system of the ventral medial prefrontal cortex in the modulation of behavioral consequences of forced swimming stress.
Acredita-se que quantidades elevadas de glutamato estejam relacionadas à neurobiologia da depressão e trabalhos recentes indicam que a quantidade de glutamato cortical está aumentada em pacientes depressivos quando comparada a indivíduos sadios. Dentre as estruturas corticais, o córtex pré-frontal medial ventral (CPFMv), dividido em infralímbico (IL)
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 20/07/2011
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8. PERFIL FARMACOLÓGICO DO TIPO ANTIDEPRESSIVO DO COMPOSTO 3-(4-FLUOROFENILSELENIL)-2,5 DIFENILSELENOFENO: ENVOLVIMENTO DO SISTEMA SEROTONINÉRGICO / ANTIDEPRESSANT-LIKE PHARMACOLOGICAL PROFILE OF 3-(4- FLUOROPHENYLSELENYL)-2,5-DIPHENYLSELENOPHENE: INVOLVEMENT OF SEROTONERGIC SYSTEM
Depression is a serious, recurrent and incapacitating psychiatric condition with a heavy social burden. The pharmacological approach to this disorder employs therapy with antidepressant drugs, which have side effects and numerous limitations. In view of the promising pharmacological properties of containing-selenium molecules, this study evaluated the effect
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 23/02/2011
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9. Antidepressant- and anxiogenic-like effects of acute 5-HT2C receptor activation in rats exposed to the forced swim test and elevated plus maze
This study investigated the behavioral effects in the forced swim test (FST) and the elevated plus-maze (EPM) of acute administration of WAY 161503 ([4aR]-8,9-dichloro-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5[6 H]-one), a selective 5-HT2C receptor agonist with putative antidepressant-like properties. Fifteen minutes after intraperitoneal (i.p.) inj
Psychology & Neuroscience. Publicado em: 2010-12
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10. Núcleo mediano da rafe e estresse de nado forçado: papel dos receptores de glutamato de tipo NMDA / Median Raphe Nucleus and Forced Swim stress: role of glutamate NMDA receptors
Exposure to uncontrollable stressors leads to behavioral and neurochemical changes, which has been associated to mal functioning of the Median Raphe Nucleus (MnRN)-Dorsal Hippocampus (DH) serotoninergic pathway. These deficits can be attenuated by intra-hippocampal injections of NMDA antagonists or 5-HT1a agonists. Activation of MnRN glutamatergic NMDA recep
Publicado em: 2010
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11. VerificaÃÃo dos efeitos de Imipramina, Paroxetina, Buspirona e Diazepam no labirinto em T elevado em ratos e camundongos / Verifying the effects of imiprimine, paroxetine, buspirone and diazepam on elevated T-maze in mice and rats
The disorders of anxiety use to have high levels of prevalence among population, with varying degrees of severity, eventually causing disability. Deakin &Graeff have conceived a theoretical model, relating distal defence, amygdala and generalized anxiety, on the one hand, and proximal defence, periaqueductal grey substance and panic, on the other. In this pr
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 14/08/2008
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12. Influence of gender and estrous cycle in the forced swim test in rats
The present work aimed at studying the influence of the estrous cycle in the forced swim test, an animal model of depression. For this, 44 male and female Wistar rats were divided into five groups according to the hormonal state in the first day of the study: metaestrus (N = 12), diestrus (N = 8), proestrus (N = 7), estrous (N = 6) and males (N = 11). They w
Psychology & Neuroscience. Publicado em: 2008-12