Forced Degradation Study
Mostrando 1-11 de 11 artigos, teses e dissertações.
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1. Tenofovir Disoproxil Fumarate: New Chemical Developments and Encouraging in vitro Biological Results for SARS-CoV-2
The recent emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led society to live with a serious public health problem. In this sense, repositioning of antiretrovirals has captured the attention of the scientific community. Tenofovir disoproxil fumarate (TDF) is an antiretroviral compound that is used to treat acquired immune defic
J. Braz. Chem. Soc.. Publicado em: 2020-08
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2. Stability Indicating Method for Determination of Benznidazole and Its Degradation Products in Active Pharmaceutical Ingredient
Currently, treatment of Chagas disease is restricted to the use of benznidazole and nifurtimox; however, nifurtimox was temporarily suspended in some countries. Based on the limitations in pharmacological treatments, it is essential to guarantee the quality of benznidazole. Therefore, this work aimed to identify the degradation products of benznidazole and t
J. Braz. Chem. Soc.. Publicado em: 2020-06
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3. Characterization and in silico Mutagenic Assessment of a New Betahistine Degradation Impurity
Currently, the pharmaceutical industry devotes great attention to drug degradation products because these compounds can offer risks to patients. A previous degradation study of betahistine (N-α-methyl-2-pyridylethylamine) conducted under different stress conditions detected three main impurities named A, B and C. Degradation products were analyzed by high-r
J. Braz. Chem. Soc.. Publicado em: 04/07/2019
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4. Electrochemical corrosion characterization of nickel aluminides in acid rain
ABSTRACT Nickel aluminides have been extensively studied in recent decades to replace superalloys, in some components of aircraft turbines, because they have excellent corrosion resistance. Many industrial cities have the problem of air pollution, which has forced the study of the degradation of these alloys in the presence of acid rain. The aim of this work
Matéria (Rio J.). Publicado em: 19/07/2018
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5. Stability-indicating RP-LC method for quantification of fusidic acid in cream
ABSTRACT Fusidic acid is an antibiotic steroid indicated for the treatment of infections caused by the genus Staphylococcus, including methicillin resistant Staphylococcus aureus strains, and other Gram-positive bacteria. In the present study, a stability-indicating reversed-phase liquid chromatography (RP-LC) method was developed and validated for the deter
Braz. J. Pharm. Sci.. Publicado em: 2016-09
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6. TIPOLOGÍA Y USOS DEL SUELO EN AGROECOSISTEMAS DEL VALLE DEL GUAMUEZ, PUTUMAYO – COLOMBIA
ABSTRACT The objective of this research was to analyze different agroecosystems located in a region of the Departamento de Putumayo (Colombia) and its sociocultural relationship with productive and land conservation contexts, based on the conceptual and methodological aspects of agroecology. A mixed methods study was carried out, and soil testing methodologi
Soc. nat.. Publicado em: 2015-08
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7. Bioconversão e degradação da venlafaxina em seu metabólito ativo / Bioconversion and degradation of venlafaxine to its active metabolite
A venlafaxina, (1-[2-dimetilamino)-1-(4-metoxifenil)etil]ciclohexanol), é um fármaco antidepressivo de segunda geração. É um dos mais potentes inibidores da recaptação de serotonina e noradrenalina, e o seu efeito terapêutico é atribuído a esta atividade. A venlafaxina é biotransformada no fígado pelas enzimas CYP2D6, CYP2C19 e CYP2C9 em O-desmet
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 03/03/2010
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8. Rapidly dissolving repaglinide powders produced by the ultra-rapid freezing process
The objective of the study was to produce rapidly dissolving formulations of the poorly water-soluble drug repaglinide using an innovative new technology, ultra-rapid freezing (URF), and to investigate the influence of excipient type on repaglinide stability. Repaglinide compositions containing different types and levels of excipients and different drug pote
Springer-Verlag.
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9. Involvement of Acid β-Glucosidase 1 in the Salvage Pathway of Ceramide Formation*
Activation of protein kinase C (PKC) promotes the salvage pathway of ceramide formation, and acid sphingomyelinase has been implicated, in part, in providing substrate for this pathway (Zeidan, Y. H., and Hannun, Y. A. (2007) J. Biol. Chem. 282, 11549–11561). In the present study, we examined whether acid β-glucosidase 1 (GBA1), which hydrolyzes gluc
American Society for Biochemistry and Molecular Biology.
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10. Airway symptoms and lung function in pipelayers exposed to thermal degradation products from MDI-based polyurethane.
OBJECTIVES: To study the prevalence of symptoms from the eyes and the upper and lower respiratory tract, lung function, and immunological sensitisation towards isocyanates in pipelayers exposed to thermal degradation products from methylene diphenyl diisocyanate (MDI)-based polyurethane (PUR). MATERIAL AND METHODS: 50 presently active and 113 formerly active
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11. Activation of NF-κB Is Essential for Hepatocyte Growth Factor-Mediated Proliferation and Tubulogenesis†
Hepatocyte growth factor (HGF) and its receptor, Met, regulate a number of biological functions in epithelial and nonepithelial cells, such as survival, motility, proliferation, and tubular morphogenesis. The transcription factor NF-κB is activated in response to a wide variety of stimuli, including growth factors, and is involved in biological responses in
American Society for Microbiology.