Folate Metabolism
Mostrando 1-12 de 80 artigos, teses e dissertações.
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1. Can the genetic polymorphisms of the folate metabolism have an influence in the polycystic ovary syndrome?
ABSTRACT Objective To investigate the association of the genetic variants of the folate metabolism genes (MTHFR C677T; MTHFR A1298C; MTR A2756G; MTRR A66G and RFC-1 A80G) with the development of polycystic ovary syndrome (PCOS). Subjects and methods This study included 203 women (99 women with PCOS and 104 controls). The genotyping was performed by PCR-R
Arch. Endocrinol. Metab.. Publicado em: 02/09/2019
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2. Folate and Cancer: Is There Any Association?
Abstract Folate plays a central role in DNA synthesis and methylation, which are essential for DNA integrity maintenance and gene expression. Folate deficiency may lead to the incorporation of uracil into DNA and chromosome breaks, increasing the risk of cancer. However, conflicting evidence has been observed depending on the type of epidemiological study, d
J. inborn errors metab. screen.. Publicado em: 30/05/2019
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3. Micronutrients: Speculation on Inborn Errors, Nutrigenomics, Evolution, the Microbiome, and Nutritional Immunity
Abstract Many micronutrients or cofactors derived from micronutrients are highly reactive, hence their role in catalysis of reactions by enzymes. The concentration of cofactors has to be kept low to avoid unwanted reactions while allowing them to bind to the (apo)enzymes that need them. A new disorder causing B6-responsive epilepsy (proline synthetase cotran
J. inborn errors metab. screen.. Publicado em: 28/02/2019
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4. Genetic Variants in Folate and Cobalamin Metabolism-Related Genes in Nonsyndromic Cleft Lip and/or Palate
Resumo O objetivo desse estudo foi avaliar a associação entre os polimorfismos no gene TCN2 (rs1801198) e no gene MTRR (rs1801394) com fissura de lábio e/ou palato não sindrômica (NSFL/P) em uma população brasileira. DNA genômico foi extraído de células bucais. Os polimorfismos nos genes TCN2 (rs1801198) e MTRR (rs1801394) foram genotipados atravé
Braz. Dent. J.. Publicado em: 2015-12
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5. Association study of folate-related enzymes (MTHFR, MTR, MTRR) genetic variants with non-obstructive male infertility in a Polish population
Spermatogenesis is a process where an important contribution of genes involved in folate-mediated one-carbon metabolism is observed. The aim of the present study was to investigate the association between male infertility and the MTHFR (677C > T; 1298A > C), MTR (2756A > G) and MTRR (66A > G) polymorphisms in a Polish population. No significant differences i
Genet. Mol. Biol.. Publicado em: 2015-03
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6. Relação do hábito alimentar e polimorfismos da MTHFR C677T com a instabilidade genômica em fumicultores gaúchos
Genetic damage can occur spontaneously under normal metabolic circumstances and can also be present in situations of dietary deficiency or inadequate intake of nutrients and excessive exposure to environmental mutagens. The purpose of this study was to evaluate the influence of the intake of micronutrients B12, B6 and folate and of polymorphism MTHFR C677T i
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2012
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7. Avaliação de polimorfismos envolvidos no metabolismo do folato em pacientes com câncer de cabeça e pescoço. / Avaliação de polimorfismos envolvidos no metabolismo do folato em pacientes com câncer de cabeça e pescoço.
O carcinoma de cabeça e pescoço pode ser decorrente de alterações na metilação do DNA associadas ao metabolismo anormal do folato. Concentrações reduzidas desse nutriente podem diminuir a capacidade de reparo do DNA, resultando em alterações celulares malignas que modulam a função e expressão dos genes. Polimorfismos em genes que participam da v
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 24/09/2010
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8. 5-Methyltetrahydrofolate-homocysteine methyltransferase gene polymorphism (MTR) and risk of head and neck cancer
The functional effect of the A>G transition at position 2756 on the MTR gene (5-methyltetrahydrofolate-homocysteine methyltransferase), involved in folate metabolism, may be a risk factor for head and neck squamous cell carcinoma (HNSCC). The frequency of MTR A2756G (rs1805087) polymorphism was compared between HNSCC patients and individuals without history
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-05
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9. Genetics of homocysteine metabolism and associated disorders
Homocysteine is a sulfur-containing amino acid derived from the metabolism of methionine, an essential amino acid, and is metabolized by one of two pathways: remethylation or transsulfuration. Abnormalities of these pathways lead to hyperhomocysteinemia. Hyperhomocysteinemia is observed in approximately 5% of the general population and is associated with an
Publicado em: 2010
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10. The effect of 677C>T and 1298A>C MTHFR polymorphisms on sulfasalazine treatment outcome in rheumatoid arthritis
Despite the availability of several new agents for the treatment of rheumatoid arthritis (RA), sulfasalazine remains the mainstay because of both cost and experience with its use. Methylenetetrahydrofolate reductase (MTHFR) is involved in folate metabolism and several polymorphisms have been described in the MTHFR gene. Of these, the 677C>T and 1298A>C polym
Brazilian Journal of Medical and Biological Research. Publicado em: 2009-07
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11. Polymorphisms in genes MTHFR, MTR and MTRR are not risk factors for cleft lip/palate in South Brazil
Non-syndromic cleft lip and palate (CL/P) occurs due to interaction between genetic and environmental factors. Abnormalities in homocysteine metabolism may play a role in its etiology due to polymorphisms in genes involved in this pathway. Because of the involvement of MTHFR, MTR and MTRR genes with folate metabolism and the evidence that maternal use of fol
Brazilian Journal of Medical and Biological Research. Publicado em: 04/05/2007
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12. Etanol, deficiência de ácido fólico e associação desses dois fatores durante a gestação de camundongos swiss / Etanol, Deficiency of Acid Fólico and Association Of these Two Factors During the Gestation of Swiss Mice
In spite of the well known teratogenic effect of ethanol, it is still the most consumed exogenous abuse substance by women of reproductive age. Ethanol also impairs the absorption, transport and metabolism of folic acid. The aim of this study was to investigate the effects of ethanol, dietary deficiency of folic acid and the association of both on the outcom
Publicado em: 2007