Fenfluramine
Mostrando 1-12 de 14 artigos, teses e dissertações.
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1. DistribuiÃÃo e anÃlise quantitativa de neurÃnios imunoreativos à enzima triptofano hidroxilase em nÃcleos de rafe de ratos desnutridos durante a vida perinatal / Distribution and quantitative analysis of neurons immunoreactive for the enzyme tryptophan hydroxylase in the raphe nuclei of animals malnourished during perinatal life
Nutritional disorders occurring during the development of the nervous system may program the fetal metabolism so long to allow the survival of individuals to changes in the nutritional environment. The perinatal protein malnutrition promotes neurochemical changes, including the levels of serotonin and limiting enzyme for its synthesis, tryptophan hydroxylase
Publicado em: 2009
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2. A brain microdialysis study on 5-HT release in freely moving rat lines selectively bred for differential 5-HT1A receptor function
Breeding for high and low hypothermic responses to systemic administration of a serotonin1A (5-HT1A) receptor agonist (8-hydroxy-2-(di-n-propylamino)tetralin, 8-OH-DPAT) has resulted in high DPAT-sensitive (HDS) and low DPAT-sensitive (LDS) lines of rats, respectively. These lines also differ in several behavioral measures associated with stress. In the pres
Brazilian Journal of Medical and Biological Research. Publicado em: 2003-02
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3. Primary pulmonary hypertension and fenfluramine use.
Not all the risk factors for primary pulmonary hypertension (PPH) are known. Appetite suppressants, including fenfluramine derivatives, are strongly suspected aetiological agents. In a 5 year retrospective study fenfluramine use was evaluated among patients referred to a medical centre specialising in the management of PPH. Fifteen (20%) of 73 patients with
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4. Anorexigen-induced pulmonary hypertension and the serotonin (5-HT) hypothesis: lessons for the future in pathogenesis
Epidemiological studies have established that fenfluramine, D-fenfluramine, and aminorex, but not other appetite suppressants, increase the risk of primary pulmonary hypertension (PH). One current hypothesis suggests that fenfluramine-like medications may act through interactions with the serotonin (5-hydroxytryptamine [5-HT]) transporter (5-HTT) located on
BioMed Central.
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5. Appetite suppressants and primary pulmonary hypertension in the United Kingdom.
OBJECTIVE--Amphetamine-like appetite suppressants, particularly fenfluramines, have been implicated in the aetiology of primary pulmonary hypertension. At one specialist centre in France 20% of patients with primary pulmonary hypertension had been exposed to fenfluramine. The prevalence of primary pulmonary hypertension associated with fenfluramines and othe
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6. Effect of fenfluramine on autistic symptoms.
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7. Risk of valvular heart disease associated with use of fenfluramine
BioMed Central.
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8. Endogenous monoamines inhibit glutamate transmission in the spinal trigeminal nucleus of the guinea-pig.
1. With the use of whole-cell patch clamp recordings in slices of guinea-pig substantia gelatinosa (SG), we studied the serotonin (5-HT)- and noradrenaline (NA)-mediated inhibition of glutamate-mediated EPSCs evoked from primary afferent stimulation. 2. The frequency of spontaneous EPSPs was reduced by 5-HT and NA. 3. The inhibition of EPSCs caused by 5-HT w
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9. Fenfluramine Disrupts the Mitral Valve Interstitial Cell Response to Serotonin
Serotonin (5HT) receptor signaling and 5HT-related agents, such as the anorexogen fenfluramine (Fen), have been associated with heart valve disease. We investigated the hypothesis that Fen may disrupt mitral valve interstitial cell (MVIC) homeostasis through its effects on mitogenesis and extracellular matrix biosynthesis. Normal and myxomatous mitral valves
American Society for Investigative Pathology.
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10. A possible role for rat intestinal surfactant-like particles in transepithelial triacylglycerol transport.
To further examine whether surfactant-like particles (DeSchryver-Kecskemeti, K., R. Eliakim, S. Carroll, W. F. Stenson, M. A. Moxley, and D. H. Alpers. 1989. J. Clin. Invest. 84:1355-1361) were involved in the transepithelial transport of lipid, alkaline phosphatase activity and surfactant-like particle content were measured in apical mucosal scrapings, ente
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11. Serotonin produces monoamine oxidase-dependent oxidative stress in human heart valves
Heart valve disease and pulmonary hypertension, in patients with carcinoid tumors and people who used the fenfluramine-phentermine combination for weight control, have been associated with high levels of serotonin in blood. The mechanism by which serotonin induces valvular changes is not well understood. We recently reported that increased oxidative stress i
American Physiological Society.
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12. Parallel Functional Activity Profiling Reveals Valvulopathogens Are Potent 5-Hydroxytryptamine2B Receptor Agonists: Implications for Drug Safety Assessment
Drug-induced valvular heart disease (VHD) is a serious side effect of a few medications, including some that are on the market. Pharmacological studies of VHD-associated medications (e.g., fenfluramine, pergolide, methysergide, and cabergoline) have revealed that they and/or their metabolites are potent 5-hydroxytryptamine2B (5-HT2B) receptor agonists. We ha
The American Society for Pharmacology and Experimental Therapeutics.