Famciclovir
Mostrando 1-12 de 25 artigos, teses e dissertações.
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1. Qual o melhor tratamento para herpes genital?
Foram encontrados três Ensaios Clínicos Randomizados (ECR) (Grau A) os quais evidenciaram que o uso do aciclovir por via oral durante o primeiro episódio de herpes genital diminui a duração das lesões, dos sintomas e da virulência quando comparado ao uso de placebo. Os efeitos adversos em ambos os grupos (aciclovir e placebo) foram raros e similare
Núcleo de Telessaúde Rio Grande do Sul. Publicado em: 12/06/2023
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2. Qual a diferença do Oseltamivir em relação aos antivirais usados para tratamento de Herpes e HIV? Qual o mecanismo de ação de cada um deles?
O Oseltamivir, classificado como inibidor da liberação da desmontagem viral, é um antiviral que inibe de forma seletiva a enzima neuroaminidase específica do vírus influenza, que é essencial para a entrada e liberação desse vírus nas células humanas. Desta forma, o oseltamivir, administrado por via oral, inibe a replicação dos vírus influenza
Núcleo de Telessaúde Rio Grande do Sul. Publicado em: 12/06/2023
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3. A atividade in vitro de seis drogas antivirais contra o alfaherpesvírus equino tipo 1 indica que o ganciclovir é uma droga promissora para estudos in vivo
RESUMO: O alfaherpesvírus equino tipo 1 (EHV-1) está amplamente distribuído nos rebanhos equinos de todo o mundo e é um dos principais agentes causadores de abortos, doença respiratória e neurológica em equinos. Ainda não há tratamento específico para a infecção pelo EHV-1 em equinos, mas o potencial da terapia antiviral tem sido investigado. Ne
Cienc. Rural. Publicado em: 03/12/2018
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4. Diagnóstico e tratamento da hepatite B
A hepatite B constitui grave problema de saúde pública. Estima-se que 350 milhões de pessoas, ou seja, 5% da população mundial sejam portadores dessa virose. Admite-se que a infecção evolui para a cura em 90% a 95% dos casos e para o estado de portador crônico nos restantes 5% a 10%; a infecção persistente pode resultar também em cirrose, insufici
Revista da Sociedade Brasileira de Medicina Tropical. Publicado em: 2000-08
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5. Safety of famciclovir in patients with herpes zoster and genital herpes.
Safety reporting from individual ongoing and completed clinical studies has demonstrated that famciclovir, the well-absorbed oral form of the antiherpesvirus agent penciclovir, has been well tolerated by more than 3,000 individuals worldwide. An integrated safety evaluation has been performed and includes over 1,600 patients from 11 completed, randomized, do
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6. Selection of an oral prodrug (BRL 42810; famciclovir) for the antiherpesvirus agent BRL 39123 [9-(4-hydroxy-3-hydroxymethylbut-l-yl)guanine; penciclovir].
The limited oral absorption in rodents of the antiherpesvirus agent 9-(4-hydroxy-3-hydroxymethylbut-l-yl)guanine (BRL 39123 [penciclovir; British approved name]) prompted a search for oral prodrugs. The 6-deoxy derivative of penciclovir (BRL 42359) and the corresponding diacetyl and dipropionyl 6-deoxy derivatives (BRL 42810 [famciclovir; British approved na
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7. Population pharmacokinetics and optimal design of paediatric studies for famciclovir
Blackwell Science Inc.
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8. In Vitro Susceptibilities of Wild-Type or Drug-Resistant Hepatitis B Virus to (−)-β-d-2,6-Diaminopurine Dioxolane and 2′-Fluoro-5-Methyl-β-l-Arabinofuranosyluracil
Prolonged treatment of chronic hepatitis B virus (HBV) infection with lamivudine ([−]-β-l-2′,3′-dideoxy-3′ thiacytidine) or famciclovir may select for viral mutants that are drug resistant due to point mutations in the polymerase gene. Determining whether such HBV mutants are sensitive to new antiviral agents is therefore important. We used a transi
American Society for Microbiology.
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9. Comparison of effects of famciclovir and valaciclovir on pathogenesis of herpes simplex virus type 2 in a murine infection model.
The effects of famciclovir (FCV) and valaciclovir (VACV) were compared in a cutaneous infection model for herpes simplex virus type 2 (HSV-2). The compounds were administered orally from day 1 to day 5 postinfection. Both compounds reduced local inflammation and virus replication in the skin. FCV markedly reduced mortality and virus replication in the nervou
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10. Detection of viral DNA to evaluate outcome of antiviral treatment of patients with recurrent genital herpes.
Culture of infectious virus, PCR amplification of viral DNA, and the appearance of genital skin lesions were used as markers to study the course of a recurrence of genital herpes in 40 patients treated with famciclovir or placebo. The highest frequency of patients with skin lesions occurred within the first 36 h following the onset of a recurrence, which als
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11. Persistence of Infectious Herpes Simplex Virus Type 2 in the Nervous System in Mice after Antiviral Chemotherapy
Young adult mice were inoculated with herpes simplex virus type 2 (HSV-2) in the ear pinna. A relatively severe infection resulted, and 45% of the mice died by 11 days postinfection. Therapy at 1 mg/ml by means of the drinking water with either famciclovir for periods of 5 or 10 days or valaciclovir for 5, 10, 15, or 20 days decreased clinical signs and redu
American Society for Microbiology.
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12. Effect of Famciclovir on Herpes Simplex Virus Type 1 Corneal Disease and Establishment of Latency in Rabbits
Famciclovir (FCV) is efficacious in the treatment of acute herpes zoster and recurrent genital infections but has not been used to treat ocular herpes simplex virus (HSV) infections. We evaluated the efficacy of orally administered FCV in treating HSV-1 epithelial keratitis and determined its effects on the establishment of latency and subsequent reactivatio
American Society for Microbiology.