Factor Viii
Mostrando 1-12 de 377 artigos, teses e dissertações.
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1. Causes of death and mortality trends related to hemophilia in Brazil, 1999 to 2016
ABSTRACT Introduction Multiple cause of death methodology enhances mortality studies beyond the traditional underlying cause of death approach. Aim: This study aims to describe causes of death and mortality issues related to haemophilia with the use of multiple-cause-of-death methodology. Methods: Annual male haemophilia mortality data was extracted from
Hematol., Transfus. Cell Ther.. Publicado em: 2021-06
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2. Impact of Arterial Procedures on Coagulation and Fibrinolysis - A Pilot Study
Abstract Objective: The main goal of our study was to assess the impact of vascular procedures on the activity of hemostatic and fibrinolytic pathways. Methods: We enrolled 38 patients with ≥ 45 years old undergoing surgery for abdominal aortic aneurysm or peripheral artery disease under general or regional anesthesia and who were hospitalized at least o
Braz. J. Cardiovasc. Surg.. Publicado em: 22/07/2019
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3. Immunohistological study of the effect of vascular Endothelial Growth Factor on the angiogenesis of mature root canals in rat molars
Abstract Tissue bioengineering has been applied to Endodontics to seek a more biological treatment. The presence of blood vessels is crucial for cell nutrition during tissue formation. Objective This study analysed the application of vascular endothelial growth factor (VEGF) in the angiogenesis of mature root canals. Material and methods Upper first molars
J. Appl. Oral Sci.. Publicado em: 21/05/2018
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4. Acquired Hemophilia presenting as Gross hematuria following Kidney Stone – A case report and review of the literature
ABSTRACT A rare condition in itself, acquired hemophilia A, seldom presents as isolated gross hematuria. It is a serious condition with a high mortality rate and thus clinical suspicion followed by prompt diagnosis is imperative (1). In fact, only 8 cases of such presentation of this condition have been reported thus far in the literature. Of these, none des
Int. braz j urol.. Publicado em: 2018-04
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5. The F309S mutation increases factor VIII secretion in human cell line
ABSTRACT OBJECTIVES: The capacity of a human cell line to secrete recombinant factor VIII with a F309S point mutation was investigated, as was the effect of the addition of chemical chaperones (betaine and sodium-4-phenylbutyrate) on the secretion of factor VIII. METHODS: This work used a vector with a F309S mutation in the A1 domain to investigate FVIII
Rev. Bras. Hematol. Hemoter.. Publicado em: 2016-06
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6. Production of Lentiviral Vectors Encoding Recombinant Factor VIII Expression in Serum-Free Suspension Cultures
ABSTRACT Lentiviral vector-mediated gene transfer offers several advantages over other gene delivery vectors when considering gene and cell therapy applications. However, using these therapies in clinical applications involves large-scale vector production in an efficient and cost-effective manner. Here we describe a high yield production of a lentivirus enc
Braz. arch. biol. technol.. Publicado em: 2015-12
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7. Effect of Fibroblast Growth Factor 2 (FGF2) and Insulin Transferrin Selenium (ITS) on In Vitro Maturation, Fertilization and Embryo Development in Sheep
The present study evaluated the effect of fibroblast growth factor 2 (FGF2) and insulin-transferrin-selenium (ITS) to the in vitro maturation and embryo culture media on ovine oocyte maturation, cleavage and embryo development. Oocytes having more than five layers of unexpanded cumulus cells and granular homogenous ooplasm were cultured into 50 μL droplets
Braz. arch. biol. technol.. Publicado em: 2015-08
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8. Murine leukemia virus-derived retroviral vector has differential integration patterns in human cell lines used to produce recombinant factor VIII
OBJECTIVE: Nowadays recombinant factor VIII is produced in murine cells including in Chinese hamster ovary (CHO) and baby hamster kidney cells (BHK). Previous studies, using the murine leukemia virus-derived retroviral vector pMFG-FVIII-P140K, modified two recombinant human cell lines, HepG2 and Hek293 to produce recombinant factor VIII. In order to characte
Rev. Bras. Hematol. Hemoter.. Publicado em: 2014-06
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9. Isolated biomolecules of pharmacological interest in hemostasis from Cerastes cerastes venom
Biomolecules from Cerastes cerastes venom have been purified and characterized. Two phospholipases isolated from Cerastes cerastes venom share 51% of homology. CC2-PLA2 exhibits antiplatelet activity that blocks coagulation. CCSV-MPase, a non-hemorrhagic Zn2+-metalloproteinase, significantly reduced the plasmatic fibrinogen level and hydrolyzes only its Bβ
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 01/05/2013
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10. Importance of immune response genes in hemophilia A
Hemophilia A is a disease caused by a deficiency of coagulation factor VIII resulting from genetic inheritance linked to chromosome X. One treatment option is the administration of plasma or recombinant FVIII. However, some patients develop inhibitors or antibodies against this factor. Inhibitors are alloantibodies that bind to the epitope of factor VIII cau
Rev. Bras. Hematol. Hemoter.. Publicado em: 2013
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11. Novas estratégias de purificação dos fatores de coagulação Fator VIII e Proteína C a partir de plasma humano empregando cromatografia líquida. / New strategies of purification of coagulation Factor VIII and Protein C from human plasma using liquid chromatography.
Neste trabalho estudou-se a purificação de fator VIII de coagulação (FVIII) e da Proteína C (PC) por cromatografia. Em coluna ANX Sepharose FF como primeira etapa de purificação do plasma permite a eluição do FVIII e da PC com bom fator de purificação, mas não a separação destas. Propomos a separação de FVIII e PC empregando cromatografia de
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 19/03/2012
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12. Fatores de transcrição da família ERF em coffea arabica : identificação e avaliação transcricional em estresses abióticos
Os fatores de transcrição ethylene response factor (ERF) desempenham importante papel no desenvolvimento e na expressão dos genes que regulam a resposta de defesa em plantas. Sendo assim, o objetivo desse estudo foi identificar os fatores de transcrição ERFs presentes no banco de dados de ESTs em Coffea arabica e avaliar a atividade transcricional de 13
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 21/12/2011