Experimental Arthritis
Mostrando 13-24 de 203 artigos, teses e dissertações.
-
13. Envolvimento muscular em modelo experimental de artrite
A artrite reumatoide (AR) é uma doença crônica, inflamatória, sistêmica, com manifestações autoimunes articulares e extra-articulares, como fraqueza e atrofia muscular. Apesar de terem profundo impacto funcional, os mecanismos envolvidos nesses processos em músculo esquelético têm sido pouco estudados. O objetivo desse trabalho foi descrever o envo
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2011
-
14. Avaliação da eficácia de um antagonista do receptor do peptídeo liberador da gastrina em modelos experimentais de artrite
O peptídeo liberador da gastrina (GRP) é o homologo mamífero da bombesina (BN). Ambos GRP e seus receptores têm sido encontrados na sinóvia de pacientes com artríte reumatoide. O receptor do peptídeo liberador da gastrina (GRPR) pode ser considerado como um alvo terapêutico para doenças inflamatórias. RC-3095 é um antagonista do receptor de GRP. E
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2011
-
15. Leukotrienes are not essential for the efficacy of a heterologous vaccine against Mycobacterium tuberculosis infection
Leukotrienes are reported to be potent proinflammatory mediators that play a role in the development of several inflammatory diseases such as asthma, rheumatoid arthritis and periodontal disease. Leukotrienes have also been associated with protection against infectious diseases. However, the role of leukotrienes in Mycobacterium tuberculosis infection is not
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-07
-
16. Análise das células inflamatórias e da proteína anexina 1 no modelo de artrite experimental e reumatóide humana. / Analysis of the inflammatory cells and annexin 1 protein in the experimental model arthritis and in the human rheumatoid .
Rheumatoid arthritis (RA) is a disease characterized by auto-antibody formation, chronic inflammation and joint oedema resulting in injury of affected cartilage and adjacent bone. In the treatment of this disease glucocorticoids (GC) have been used, wich induce genic expression of anti-inflammatory mediators, such as the annexin 1 protein (Anx-A1), and proin
Publicado em: 2010
-
17. Estudo da prevalÃncia dos auto-anticorpos marcadores de doenÃas reumÃticas em pacientes com disfunÃÃo de articulaÃÃo temporomandibula. / A study on the prevalence of auto antibodies to rheumatic diseases markers in patients with temporomandibular joint disorders (TMD)
O presente estudo tem a finalidade de avaliar se os indivÃduos portadores de desordem temporomandibular (DTM) apresentam, no momento do diagnÃstico clÃnico, alguns marcadores sorolÃgicos, como o fator reumatÃide (FR), o anticorpo anti-peptÃdeo citrulinado cÃclico (anti-CCP) e o fator antinuclear (FAN), que sÃo comumente associados à incidÃncia e ev
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 05/02/2009
-
18. Monitoramento sorológico e da presença do DNA pró-viral do lentivirus caprino (CAEV) no sangue e semen de reprodutores infectados
Caprine arthritis-encephalitis (CAE) is a multisystemic viral syndrome in goats caused by small ruminant lentivirus (CAEV). The control measures prescribed for CAEV control are based on the indentification of infected animals through a suitable serological test. The aim of this work was to improve the CAE control measures through the association of indirect
Publicado em: 2009
-
19. Evaluation of antinociceptive and anti-inflammatory activity of new derivatives N-acilidrazônicos (NAH) pyrazine. / Avaliação da atividade antinociceptiva e antiinflamatória de novos derivados N-acilidrazônicos (NAH) pirazínicos.
A new series of derivatives N-acihidrazone (NAH) pirazinic was rationally planned be applied the strategy of simplification molecular on the unit quinoxalinic of prototype LASSBio-1018, identified as a potent anti-inflammatory and analgesic in LASSBio designed by application the biososterism of rings on LASSBio-319. The new series of 21 derivatives were synt
Publicado em: 2009
-
20. Vacina de DNA (hsp65 M. Leprae) para Paracoccidioidomicose Experimental: atividade imunogênica e terapêutica
Heat shock proteins (HSPs) are recognized as important molecules in the modulation of the immune system and are highly conserved among different organisms. The DNA-hsp65 vaccine from Mycobacterium leprae (M. leprae) has been shown to have prophylactic and immunotherapeutic effects against various diseases, for instance, tuberculosis, arthritis and leishmania
Publicado em: 2008
-
21. SÃntese, comprovaÃÃo estrutural, modelagem molecular e avaliaÃÃo da atividade antiinflamatÃria de novos derivados tiazolidÃnicos
Among the pathology that the involved inflammatory process deserves the outstanding rheumatoid arthritis, cancer and acute pancreatitis, where the latter can be originated by a chronic inflammation. Some inflammatory mediators are observed from these diseases, such as TNF-α, iNOS, and NF-kB that are properly modulated by PPARs (Peroxisome proliferator-a
Publicado em: 2008
-
22. Estudo do efeito da fraÃÃo nÃo dialisÃvel do lÃtex de Calotropis procera (ait) R. Br em modelos experimentais de inflamaÃÃo, com Ãnfase em artrite / Study of the effect of the non-dialyzable fraction of Calotropis procera (Ait) R. Br latex in experimental models of inflammation, with emphasis in arthritis
The objective of this dissertation was to investigate the effect of the latex from Calotropis procera in experimental models of inflammation, with special focus on arthritis. The plant belongs to Asclepiadaceae family and is largely found in Northeast of Brazil. The plant latex presents clear anti-inflammatory effects, which is kept by its non-dialyzable pro
Publicado em: 2007
-
23. Efeito de frações obtidas da fucoidana de Fucus vesiculosus em modelo experimental de artrite induzida por Zymosan
The fucoidan from Fucus vesiculosus is known for having diverse biological properties. This study analyzed the therapeutic action of populations of commercial fucoidan (F. vesiculosus) on zymosan-induced arthritis. Three populations of fucoidan were obtained after acetone fractionation; these were denominated F1 (52.3%), F2 (36.7%) and F3 (10.7%). Chemical a
Publicado em: 2007
-
24. Experimental model of temporomandibular joint arthritis induced by zymozan in rats and the study of the role of nitric oxide / Padronização de modelo experimental de artrite na articulação temporomandibular induzida por zymozan em ratos e estudo do papel do óxido nítrico
Temproromandibular disfunction (TMD) is related to a masticatory system disfunction which can include the temporomandibular joint (TMJ), the masticatory muscles and/or other related structures. TMJ inflammatory disorders are one of the major pathology of TMD afecting a great number of patients. Although TMJs inflammation and pain are important cinical entiti
Publicado em: 2006