Experimental Animal Models
Mostrando 13-24 de 329 artigos, teses e dissertações.
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13. Voluntary wheel running: patterns and physiological effects in mice
Exercise can prevent and improve the pathophysiology of diseases and promote healthy aging. Thus, understanding the mechanisms that regulate the beneficial effects of exercise may lead to the development of new strategies to enhance quality of life and to counteract chronic diseases. Voluntary wheel running is an interesting model to study the effects of exe
Braz J Med Biol Res. Publicado em: 10/12/2018
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14. Platelet activating factor receptor antagonists improve the efficacy of experimental chemo- and radiotherapy
Platelet activating factor is a lipid mediator of inflammation, and in recent decades, it has emerged as an important factor in tumor outcomes. Platelet activating factor acts by specific binding to its receptor, which is present in both tumor cells and cells that infiltrate tumors. Pro-tumorigenic effects of platelet activating factor receptor in tumors inc
Clinics. Publicado em: 11/10/2018
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15. Impact of autologous whole blood administration upon experimental mouse models of acute Trypanosoma cruzi infection
Abstract Background: Autologous whole blood (AWB) administration is described as alternative/complementary medical practice widely employed in medical and veterinary therapy against infections, chronic pathologies and neoplasias. Our aim is to investigate in vivo biological effect of AWB using healthy murine models under the course of Trypanosoma cruzi acut
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 21/09/2018
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16. Antihypoxic activities of Crataegus pentaegyn and Crataegus microphylla fruits-an in vivo assay
ABSTRACT The aim of this study was to evaluate anti-hypoxia activity of polyphenolic extracts of Crataegus microphylla and Crataegus pentaegyn on mice. Three experimental models of hypoxia were considered, including asphyctic hypoxia, haemic hypoxia, and circulatory hypoxia. Polyphenolic extract of both plants exhibited significant anti-hypoxic activity and
Braz. J. Pharm. Sci.. Publicado em: 26/07/2018
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17. Response to different benznidazole doses in animal models of chronic phase Chagas disease: a critical review
Abstract Chagas disease is a protozoan infection that was identified over a century ago. No drugs are available to treat the indeterminate and determinate chronic phases of the disease. Success of a drug design is dependent on correct biological evaluation. Concerning new drug designs for Chagas disease, it is essential to first identify the most effective,
Rev. Soc. Bras. Med. Trop.. Publicado em: 2018-04
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18. Establishment of a Pathogenicity Index for Mice to Pasteurella multocida Strains Isolated from Poultry and Swine
ABSTRACT Fowl cholera is a contagious disease that results from infection by the bacterium Pasteurella multocida. This microorganism is extensively distributed among animal species, but little is known regarding it’s pathogenesis and specificity to various hosts. Many studies using pathogenicity evaluation methods are subjective and difficult to quantify b
Braz. J. Poult. Sci.. Publicado em: 2018-04
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19. Zika virus congenital syndrome: experimental models and clinical aspects
Abstract Viral infections have long been the cause of severe diseases to humans, increasing morbidity and mortality rates worldwide, either in rich or poor countries. Yellow fever virus, H1N1 virus, HIV, dengue virus, hepatitis B and C are well known threats to human health, being responsible for many million deaths annually, associated to a huge economic an
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 23/10/2017
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20. Agreement, correlation, and kinetics of the alveolar bone-loss measurement methodologies in a ligature-induced periodontitis animal model
Abstract Periodontal research involves the use of animal models to better understand the biological processes of periodontal diseases and the potential of new or existing therapies. Currently, ligature-induced periodontitis in rats is the main model used in periodontal research, in this model, alveolar bone loss (ABL) is the main parameter evaluated by radio
J. Appl. Oral Sci.. Publicado em: 2017-10
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21. Animal models in biological and biomedical research - experimental and ethical concerns
ABSTRACT Animal models have been used in experimental research to increase human knowledge and contribute to finding solutions to biological and biomedical questions. However, increased concern for the welfare of the animals used, and a growing awareness of the concept of animal rights, has brought a greater focus on the related ethical issues. In this revie
An. Acad. Bras. Ciênc.. Publicado em: 04/09/2017
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22. Is Forced Swimming Immobility a Good Endpoint for Modeling Negative Symptoms of Schizophrenia? - Study of Sub-Anesthetic Ketamine Repeated Administration Effects
ABSTRACT Immobility time in the forced swimming has been described as analogous to emotional blunting or apathy and has been used for characterizing schizophrenia animal models. Several clinical studies support the use of NMDA receptor antagonists to model schizophrenia in rodents. Some works describe the effects of ketamine on immobility behavior but there
An. Acad. Bras. Ciênc.. Publicado em: 17/08/2017
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23. Penile alterations at early stage of type 1 diabetes in rats
ABSTRACT Objective Diabetes affects the erectile function significantly. However, the penile alterations in the early stage of diabetes in experimental animal models have not been well studied. We examined the changes of the penis and its main erectile components in diabetic rats. Materials and methods Male Sprague-Dawley rats were divided into 2 groups:
Int. braz j urol.. Publicado em: 2017-08
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24. Accuracy and reliability of a videogrammetry system in the analysis of displacement of Wistar rats
Abstract Aims The behavior of laboratory animals has been studied through displacement, with different objectives by researchers. Methods Although different methods have already been used in the tracking of laboratory animals, manual tracking mode videogrammetry for 2D analysis of displacement has not been observed in animal studies. The aim of this study
Motriz: rev. educ. fis.. Publicado em: 27/07/2017