Platelet activating factor receptor antagonists improve the efficacy of experimental chemo- and radiotherapy
AUTOR(ES)
da Silva Junior, Ildefonso Alves, de Sousa Andrade, Luciana Nogueira, Jancar, Sonia, Chammas, Roger
FONTE
Clinics
DATA DE PUBLICAÇÃO
11/10/2018
RESUMO
Platelet activating factor is a lipid mediator of inflammation, and in recent decades, it has emerged as an important factor in tumor outcomes. Platelet activating factor acts by specific binding to its receptor, which is present in both tumor cells and cells that infiltrate tumors. Pro-tumorigenic effects of platelet activating factor receptor in tumors includes promotion of tumor cell proliferation, production of survival signals, migration of vascular cells and formation of new vessels and stimulation of dendritic cells and macrophages suppressor phenotype. In experimental models, blocking of platelet activating factor receptor reduced tumor growth and increased animal survival. During chemotherapy and radiotherapy, tumor cells that survive treatment undergo accelerated proliferation, a phenomenon known as tumor cell repopulation. Work from our group and others showed that these treatments induce overproduction of platelet activating factor-like molecules and increase expression of its receptor in tumor cells. In this scenario, antagonists of platelet activating factor markedly reduced tumor repopulation. Here, we note that combining chemo- and radiotherapy with platelet activating factor antagonists could be a promising strategy for cancer treatment.
Documentos Relacionados
- Characterization of a platelet-activating factor receptor antagonist isolated from haifenteng (Piper futokadsura): specific inhibition of in vitro and in vivo platelet-activating factor-induced effects.
- Two of the usual suspects, platelet-activating factor and its receptor, implicated in acute lung injury
- Platelet-activating factor: mediator of the third pathway of platelet aggregation? A study in three patients with deficient platelet-activating factor synthesis.
- Absence of platelet-activating factor receptor protects mice from osteoporosis following ovariectomy
- Allergy and Immunology: Platelet-Activating Factor