Eukaryotic Transcription
Mostrando 1-12 de 996 artigos, teses e dissertações.
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1. Histone deacetylase inhibitors as potential treatment for spinal muscular atrophy
Histone acetylation plays an important role in regulation of transcription in eukaryotic cells by promoting a more relaxed chromatin structure necessary for transcriptional activation. Histone deacetylases (HDACs) remove acetyl groups and suppress gene expression. HDAC inhibitors (HDACIs) are a group of small molecules that promote gene transcription by chro
Genet. Mol. Biol.. Publicado em: 2013
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2. Biogênese, estabilidade e localização sub-celular de RNAs não-codificadores longos expressos em regiões intrônicas do genoma humano / Biogenesis, stability and sub-cellular localization of long non-coding RNAs expressed in intronic regions of the human genome
Trabalhos recentes indicam que a maior parte do transcriptoma de células de mamíferos é composto por RNAs não-codificadores de proteínas (ncRNAs). Nosso grupo tem identificado e caracterizado ncRNAs longos (>200 nt), sem splicing, expressos em regiões intrônicas de genes codificadores de proteína. Contudo, a biogênese, processamento e localização
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 26/03/2012
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3. Relationships between chromatin remodeling and DNA damage repair induced by 8-methoxypsoralen and UVA in yeast Saccharomyces cerevisiae
Eukaryotic cells have developed mechanisms to prevent genomic instability, such as DNA damage detection and repair, control of cell cycle progression and cell death induction. The bifunctional compound furocumarin 8-methoxy-psoralen (8-MOP) is widely used in the treatment of various inflammatory skin diseases. In this review, we summarize recent data about t
Genet. Mol. Biol.. Publicado em: 2012
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4. The Na+/glucose cotransporters: from genes to therapy
Glucose enters eukaryotic cells via two types of membrane-associated carrier proteins, the Na+/glucose cotransporters (SGLT) and the facilitative glucose transporters (GLUT). The SGLT family consists of six members. Among them, the SGLT1 and SGLT2 proteins, encoded by the solute carrier genes SLC5A1 and SLC5A2, respectively, are believed to be the most impor
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-11
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5. Expression of bacterial virulence factors and cytokines during in vitro macrophage infection by enteroinvasive Escherichia coli and Shigella flexneri: a comparative study
Enteroinvasive Escherichia coli (EIEC) and Shigellaspp cause bacillary dysentery in humans by invading and multiplying within epithelial cells of the colonic mucosa. Although EIEC and Shigellashare many genetic and biochemical similarities, the illness caused by Shigellais more severe. Thus, genomic and structure-function molecular studies on the biological
Memórias do Instituto Oswaldo Cruz. Publicado em: 2010-09
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6. Effects of L1-ORF2 fragments on green fluorescent protein gene expression
The retrotransposon known as long interspersed nuclear element-1 (L1) is 6 kb long, although most L1s in mammalian and other eukaryotic cells are truncated. L1 contains two open reading frames, ORF1 and ORF2, that code for an RNA-binding protein and a protein with endonuclease and reverse transcriptase activities, respectively. In this work, we examined the
Genetics and Molecular Biology. Publicado em: 28/08/2009
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7. Expressão, purificação e caracterização estrutural dos fatores de transcrição bZIP SCF12 e SCF5 de cana-de-açucar / Expression, purification and structural characterization of the sugarcane bZIP transcription factors SCF12 and SCF5
The bZIP transcription factors are present in eukaryotic organisms and are involved in the regulation of gene expression and many intracellular processes. These factors bind specific DNA sequences and are able to recognize regulatory sequences of a gene promoter. The bZIPs are characterized by a conserved region rich in basic amino acid residues as well as b
Publicado em: 2008
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8. RNA polymerase I promoter and splice acceptor site recognition affect gene expression in non-pathogenic Leishmania species
Leishmania (Sauroleishmania) tarentolae has biotechnological potential for use as live vaccine against visceral leishmaniasis and as a system for the over expression of eukaryotic proteins that possess accurate post-translational modifications. For both purposes, new systems for protein expression in this non-pathogenic protozoan are necessary. The ribosomal
Memórias do Instituto Oswaldo Cruz. Publicado em: 31/08/2007
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9. Cloning and molecular characterization of Trypanosoma cruzi U2, U4, U5, and U6 small nuclear RNAs
Small nuclear RNAs (snRNAs) are important factors in the functioning of eukaryotic cells that form several small complexes with proteins; these ribonucleoprotein particles (U snRNPs) have an essential role in the pre-mRNA processing, particularly in splicing, catalyzed by spliceosomes, large RNA-protein complexes composed of various snRNPs. Even though they
Memórias do Instituto Oswaldo Cruz. Publicado em: 2007-02
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10. Characterization of the RNA Polymerase B Transcricional Factor 3 (btf3) of Trichoderma reesei and the effect of its knockout on gene expression in stress by heat shock / Caracterização do gene do Fator Transcricional 3 da RNA Polimerase B (btf3) de Trichoderma reesei e o efeito de seu nocaute sobre a expressão gênica no estresse por choque térmico
Transcription by RNA polymerase II (RNA polymerase B) and protein synthesis are the most important metabolic processes in eukaryotic cells, and they are involved in the control of gene expression. Trichoderma reesei was used as model of study for the development of this study. This filamentous fungus is a microorganism that has been used by some laboratories
Publicado em: 2007
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11. The 2.1-Å crystal structure of an archaeal preinitiation complex: TATA-box-binding protein/transcription factor (II)B core/TATA-box
Archaea possess a basal transcriptional apparatus that resembles that of eukaryotes. Here we report the 2.1-Å crystal structure of the archaeal transcription factor complex formed by the TATA-box-binding protein (TBP), the transcription factor IIB homolog, and a DNA target, all from the hyperthermophile Pyrococcus woesei. The overall fold of these two basa
The National Academy of Sciences of the USA.
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12. Transcription factor IID in the Archaea: sequences in the Thermococcus celer genome would encode a product closely related to the TATA-binding protein of eukaryotes.
The first step in transcription initiation in eukaryotes is mediated by the TATA-binding protein, a subunit of the transcription factor IID complex. We have cloned and sequenced the gene for a presumptive homolog of this eukaryotic protein from Thermococcus celer, a member of the Archaea (formerly archaebacteria). The protein encoded by the archaeal gene is