Ethynyl Estradiol
Mostrando 1-4 de 4 artigos, teses e dissertações.
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1. Bioequivalence study of two formulations with 2 mg of cyproterone acetate and 0,35 mg ethynilestradiol in healthy volunteers by high-performance liquid coupled to mass spectrometry / Estudo de bioequivalencia entre duas formulações contendo 2 mg de acetato de ciproterona e 0,035 mg de etinilestradiol em voluntarias sadias atraves de cromatografia liquida acoplada a espectrometria de massas
O objetivo deste estudo foi avaliar a bioequivalência de duas formulações de acetato de ciproterona e etinilestradiol em drágea vs comprimido (Selene® comprimidos, Laboratório Eurofarma Ltda., formulação Teste e Diane® 35, Schering do Brasil, como Referência) após administração oral em 48 voluntárias adultas sadias. O estudo foi do tipo aberto,
Publicado em: 2008
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2. Raloxifene (LY139481 HCI) prevents bone loss and reduces serum cholesterol without causing uterine hypertrophy in ovariectomized rats.
There is a medical need for an agent with the positive effects of estrogen on bone and the cardiovascular system, but without the negative effects on reproductive tissue. Raloxifene (LY139481 HCI) is a benzothiophene derivative that binds to the estrogen receptor and inhibits the effects of estrogen on the uterus. In an ovariectomized (OVX) rat model we inve
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3. 4-Hydroxylation of estradiol by human uterine myometrium and myoma microsomes: implications for the mechanism of uterine tumorigenesis.
Estradiol is converted to catechol estrogens via 2- and 4-hydroxylation by cytochrome P450 enzymes. 4-Hydroxyestradiol elicits biological activities distinct from estradiol, most notably an oxidant stress response induced by free radicals generated by metabolic redox cycling reactions. In this study, we have examined 2- and 4-hydroxylation of estradiol by mi
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4. Regulation of biliary cholesterol secretion in the rat. Role of hepatic cholesterol esterification.
Although the significance of the enterohepatic circulation of bile salts in the solubilization and biliary excretion of cholesterol is well established, little is known about the intrahepatic determinants of biliary cholesterol output. Studies were undertaken to elucidate some of these determinants in the rat. Feeding 1% diosgenin for 1 wk increased biliary