Ethidium Bromide
Mostrando 13-24 de 655 artigos, teses e dissertações.
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13. Megazol and its bioisostere 4H-1,2,4-triazole: comparing the trypanocidal, cytotoxic and genotoxic activities and their in vitro and in silico interactions with the Trypanosoma brucei nitroreductase enzyme
Megazol (7) is a 5-nitroimidazole that is highly active against Trypanosoma cruzi and Trypanosoma brucei, as well as drug-resistant forms of trypanosomiasis. Compound 7 is not used clinically due to its mutagenic and genotoxic properties, but has been largely used as a lead compound. Here, we compared the activity of 7 with its 4H-1,2,4-triazole bioisostere
Mem. Inst. Oswaldo Cruz. Publicado em: 18/03/2014
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14. Resistance of cervical adenocarcinoma cells (HeLa) to venom from the scorpion Centruroides limpidus limpidus
Background : The venom of Centruroides limpidus limpidus (Cll) is a mixture of pharmacologically active principles. The most important of these are toxic proteins that interact both selectively and specifically with different cellular targets such as ion channels. Recently, anticancer properties of the venom from other scorpion species have been described.
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 02/09/2013
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15. 17-β ESTRADIOL E RESVERATROL NOS PARÂMETROS BIOQUÍMICOS E HEMATOLÓGICOS DE RATAS OVARIECTOMIZADAS SUBMETIDAS A DESMIELINIZAÇÃO PELO BROMETO DE ETÍDIO / 17-β ESTRADIOL AND RESVERATROL IN BIOCHEMISTRY AND HEMATOLOGY OF OVARIECTOMIZED RATS SUBMITTED TO DEMYELINATION BY ETHIDIUM BROMIDE
Dentre as doenças neurodegenerativas, as que causam desmielinização do sistema nervoso central tem grande importância, como a esclerose múltipla (EM) que acomete adultos jovens e de meia-idade. Neste sentido, o 17-β estradiol e o resveratrol surgem como substâncias promissoras devido as suas ações antioxidante, antiinflamatória e neuroprotetora
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 05/03/2012
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16. The influence of GC/AT composition on intercalating and semi-intercalating binding of ethidium bromide to DNA
Os parâmetros de ligação de brometo de etídio (EtBr) com DNA em diversas proporções GC/AT foram determinados usando espectroscopia de absorção e fluorescência. Nossos dados experimentais demonstram claramente a co-existência de tipos de ligação "forte" fluorescente e não-fluorescente em baixas concentrações de EtBr. O complexo fluorescente cor
J. Braz. Chem. Soc.. Publicado em: 11/12/2012
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17. In vitro inhibitory effects of imatinib mesylate on stromal cells and hematopoietic progenitors from bone marrow
Imatinib mesylate (IM) is used to treat chronic myeloid leukemia (CML) because it selectively inhibits tyrosine kinase, which is a hallmark of CML oncogenesis. Recent studies have shown that IM inhibits the growth of several non-malignant hematopoietic and fibroblast cells from bone marrow (BM). The aim of the present study was to evaluate the effects of IM
Braz J Med Biol Res. Publicado em: 25/09/2012
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18. Phenolic compounds from Sidastrum micranthum (A. St.-Hil.) fryxell and evaluation of acacetin and 7,4'-Di-O-methylisoscutellarein as motulator of bacterial drug resistence
From the aerial parts of Sidastrum micranthum (A. St.-Hil.) Fryxell (Malvaceae) were isolated m-methoxy-p-hydroxy-benzaldehyde, o-hydroxy-benzoic acid, acacetin, quercetin, 7,4′-Di-O-methylisoscutellarein, genkwanin and tiliroside. These compounds were identified by data analyses of spectroscopic methods. Although acacetin and 7,4′-Di-O-methylisoscutella
Química Nova. Publicado em: 2011
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19. Purificação de DNA plasmidial de Bacillus thuringiensis por ultracentrifugação em gradiente de cloreto de césio.
DNA plasmid. Bacillus thuringiensis e seus plasmídeos. Purificação de DNA plasmidial por ultracentrifugação em gradiente de cloreto de césio (CsCl). Estirpes utilizadas neste trabalho. Condições de crescimento e extração de DNA plasmidial. Preparo do DNA plasmidial e ultracentrifugação gradiente de CsCl. Identificação e coleta das bandas de int
Seropédica: Embrapa Agrobiologia. Publicado em: 2011
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20. Estudo do potencial anticÃncer de novos derivados acridÃnicos sintÃticos em modelos experimentais in vitro. / Study of the potential of new anticancer synthetic acridine derivatives in experimental models in vitro.
Acridines are planar aromatic polycyclic molecules that have the ability to progress in nuclear DNA. Many of its representatives have antibacterial, antiparasitic and antitumor. This study evaluated the cytotoxic potential of 22 new acridine compounds in strains of human tumor cells. Among these, four compounds [5-(acridin-9-yl-methilene)-3-(4-methyl-benzyl)
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 20/01/2010
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21. Proteomic analysis of cytosolic proteins associated with petite mutations in Candida glabrata
The incidence of superficial or deep-seated infections due to Candida glabrata has increased markedly, probably because of the low intrinsic susceptibility of this microorganism to azole antifungals and its relatively high propensity to acquire azole resistance. To determine changes in the C. glabrata proteome associated with petite mutations, cytosolic extr
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-12
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22. Effect of galbanic acid, a sesquiterpene coumarin from Ferula szowitsiana, as an inhibitor of efflux mechanism in resistant clinical isolates of Staphylococcus aureus
Galbanic acid, a sesquiterpene coumarin from Ferula szowitsiana roots, was investigated for its potentiating effect on the antimicrobial activity of antibiotics as well as ethidium bromide, in 6 multidrug resistance (MDR) clinical isolates of Staphylococcus aureus. Galbanic acid had inhibitory effect on none of the isolated bacteria tested (up to 800 µg /ml
Brazilian Journal of Microbiology. Publicado em: 2010-10
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23. Epidemiology and antimicrobial resistance of staphylococci isolated from different infectious diseases
A total of 187 isolates from 470 clinical specimens were collected from three hospitals in El-Minia governorate and identified as 132 Staphylococcus aureus strains and 55 coagulase-negative staphylococci (CoNS) strains. Susceptibility of isolates to antimicrobial agents was tested by the agar dilution method. The isolated S. aureus strains showed low resista
Brazilian Journal of Microbiology. Publicado em: 2010-06
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24. Desenvolvimento de biossensores eletroquímicos, utilizando matriz polimérica modificada com biomoléculas, para o diagnóstico de câncer de próstata e hepatite C
The development of biologic sensors has become a wide activity in science seeking mainly health and environmental issues. The biosensor development in laboratory has been investigated by many researchers seeking sensitivity, specific, low cost and portable devices. The electrochemical techniques are used in the largest number of works due to the easiness in
Publicado em: 2010