Erythropoiesis
Mostrando 25-36 de 306 artigos, teses e dissertações.
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25. Regulation of Erythropoiesis. XV. Neonatal Erythropoiesis and the Effect of Nephrectomy *
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26. Autonomous Erythropoiesis during Erythroblastic Crisis of Chronic Myelocytic Leukemia
Two patients with chronic myelocytic leukemia who developed an erythroblastic rather than a myeloblastic phase were studied with respect to whether or not the megaloblastic erythropoiesis was subject to normal control mechanisms. After transfusion, no significant reduction was observed in the percentage of nucleated erythroid precursors or of proerythroblast
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27. Erythropoietin Production in Virulent Malaria
Erythropoietin, the hormone responsible for stimulating erythrocyte production, was shown to increase significantly in the serum of mice during virulent malaria infection. Although erythropoiesis was enhanced, it did not keep pace with the rate of erythocyte destruction; hence all Plasmodium berghei-infected mice quickly succumbed to the deleterious conseque
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28. The Rb tumor suppressor is required for stress erythropoiesis
The retinoblastoma tumor suppressor gene plays important roles in cell cycle control, differentiation and survival during development and is functionally inactivated in most human cancers. Early studies using gene targeting in mice suggested a critical role for pRb in erythropoiesis, while more recent experiments have suggested that many of the abnormal embr
Nature Publishing Group.
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29. The glucocorticoid receptor is required for stress erythropoiesis
The glucocorticoid receptor (GR) coordinates a multitude of physiological responses in vivo. In vitro, glucocorticoids are required for sustained proliferation of erythroid progenitors (ebls). Here, we analyze the impact of the GR on erythropoiesis in vivo, using GR-deficient mice or mice expressing a GR defective for transactivation. In vitro, sustained pro
Cold Spring Harbor Laboratory Press.
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30. C-type virus particle formation in erythroblastic islands in spleens of C3Hf mice injected with erythropoietin.
Previous studies suggested a possible association between C-type virus particle formation and erythropoiesis. In this experiment, normal C3Hf mice were injected with erythropoietin in order to increase the rate of erythropoiesis. Sections of spleen from these animals revealed extensive areas of erythroblasts. C-type particles, budding from erythroblasts, wer
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31. Changes in minor transcripts from the alpha 1 and beta maj globin and glutathione peroxidase genes during erythropoiesis.
We have analysed the transcriptional regulation of the murine alpha 1 and beta maj globin genes and the glutathione peroxidase (GSHPx) gene, which are all highly expressed during erythropoiesis. The levels of minor RNAs compared to the major message were monitored throughout differentiation within the erythroid lineage. For each gene, upstream transcripts ar
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32. Comparative ferrokinetic study with initial and extended iron clearance models.
Erythrokinetic studies were performed on 10 patients with chronic myelofibrosis and 11 patients with myelodysplasia (MDS). Values for plasma iron turnover, marrow iron turnover, and erythron transferrin uptake were derived using two ferrokinetic models. One entailed analysis of the extended plasma iron clearance over a number of days, the other comprised ana
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33. In-vitro studies of ineffective erythropoiesis in rheumatoid arthritis
Ineffective erythropoiesis was assessed in a series of 32 patients with rheumatoid arthritis by means of a new in-vitro method which measures the release of haem from a labelled cohort of erythroblasts in culture. Haem release was significantly increased in patients with the anaemia of chronic disorders but was normal in those who were not anaemic or who had
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34. Effect of parathyroid hormone on erythropoiesis.
Inhibitors of erythropoiesis have been found in the blood of uremic patients but their nature has not been identified. These patients have excess blood levels of parathyroid hormone (PTH) and it is possible that PTH inhibits erythropoiesis. The present study was undertaken to examine the effect of intact PTH molecules and some of its fragments on human perip
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35. Tumor necrosis factor alpha and the anemia associated with murine malaria.
The anemia associated with malaria is complex, and multiple factors contribute to its severity. An increased destruction and a decreased production of erythrocytes are involved; however, the mechanisms responsible remain unclear. Tumor necrosis factor alpha (TNF-alpha), released by macrophages in response to infection, is thought to play a role through its a
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36. In vivo requirements for GATA-1 functional domains during primitive and definitive erythropoiesis
GATA-1 is a transcription factor essential for erythroid/megakaryocytic cell differentiation. To investigate the contribution of individual domains of GATA-1 to its activity, transgenic mice expressing either an N-terminus, or an N- or C-terminal zinc finger deletion of GATA-1 (ΔNT, ΔNF or ΔCF, respectively) were generated and crossed to GATA-1 germline m
Oxford University Press.