In-vitro studies of ineffective erythropoiesis in rheumatoid arthritis
AUTOR(ES)
Williams, R. A.
RESUMO
Ineffective erythropoiesis was assessed in a series of 32 patients with rheumatoid arthritis by means of a new in-vitro method which measures the release of haem from a labelled cohort of erythroblasts in culture. Haem release was significantly increased in patients with the anaemia of chronic disorders but was normal in those who were not anaemic or who had an iron-deficiency anaemia. In 2 patients with anaemia of chronic disorders haem release returned to normal after successful antirheumatic therapy. The increased ineffective erythropoiesis in patients with rheumatoid arthritis and anaemia of chronic disorders appeared to be unrelated to functional iron deficiency and was not attributable to a serum factor.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1001031Documentos Relacionados
- In-vitro reactions of lymphocytes in rheumatoid arthritis and other rheumatic diseases.
- In-vitro T cell mediated function in patients with active rheumatoid arthritis.
- Role of ineffective erythropoiesis in the anaemia of rheumatoid arthritis.
- Immunoregulatory effects of alpha-interferon. Effects on in-vitro antibody synthesis by lymphocytes from patients with rheumatoid arthritis.
- Leucocyte function in patients with rheumatoid arthritis: quantitative in-vivo leucocyte mobilisation and in-vitro functions of blood and exudate leucocytes.