Epigenetic And Stress Oxidative
Mostrando 1-4 de 4 artigos, teses e dissertações.
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1. An association study of FOXO3 variant and longevity
Abstract Human longevity is a polygenic and multifactorial trait. Pathways related to lifespan are complex and involve molecular, cellular, and environmental processes. In this analytical observational study, we evaluated the relationship between environment factors, oxidative stress status, DNA integrity level, and the association of FOXO3 (rs2802292), SOD2
Genet. Mol. Biol.. Publicado em: 11/06/2018
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2. Isolamento de uma subpopulação de células de melanoma murino com características de progenitoras tumorais e análises de suas propriedades tronculares e tumorigênicas / Isolation of the subpopulation of melanoma cells with characteristics progenitors cells and analysis of their properties stems and tumorigenics
O melanoma é o câncer de pele existente mais agressivo e sua resistência para muitas modalidades terapêuticas é conhecida. É plausível a conjectura de que a resistência deste tumor esteja intimamente relacionada à presença de uma subpopulação de células progenitoras tumorais. Com base nesta informação nosso trabalho propôs isolar células de
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 26/01/2011
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3. Epigenetic Silencing of Stk39 in B-Cell Lymphoma Inhibits Apoptosis from Genotoxic Stress
B-cell lymphomas, the most frequent human immune system malignancies, often contain dysregulated TCL1 oncogene expression. TCL1 transgenic (TCL1-tg) mice develop a spectrum of B-cell malignancies, supporting an oncogenic role for TCL1 in B cells. Our prior global survey of DNA methylation patterns in TCL1-tg B-cell lymphomas identified many lymphoma-specific
American Society for Investigative Pathology.
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4. Effect of oxidative DNA damage in promoter elements on transcription factor binding.
Reactive oxygen species produced by endogenous metabolic activity and exposure to a multitude of exogenous agents impact cells in a variety of ways. The DNA base damage 8-oxodeoxyguanosine (8-oxodG) is a prominent indicator of oxidative stress and has been well-characterized as a premutagenic lesion in mammalian cells and putative initiator of the carcinogen