Epidermal Growth Factor Receptor
Mostrando 13-24 de 1081 artigos, teses e dissertações.
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13. Chromogenic in situ hybridization compared with other approaches to evaluate HER2/neu status in breast carcinomas
Human epidermal growth factor receptor 2 (HER2) has been evaluated in breast cancer patients to identify those most likely to benefit from herceptin-targeted therapy. HER2 amplification, detected in 20-30% of invasive breast tumors, is associated with reduced survival and metastasis. The most frequently used technique for evaluating HER2 protein status as a
Braz J Med Biol Res. Publicado em: 19/03/2013
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14. Epidermal growth factor receptor mutation frequency and non-small cell lung cancer management: implication for treatment choices
Clinics. Publicado em: 2012-11
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15. Epidermal growth factor receptor inhibitors in non-small cell lung cancer: current status and future perspectives
Two classes of epidermal growth factor receptor (EGFR) inhibitors are currently available for clinical use: tyrosine-kinase inhibitors (TKIs) and monoclonal antibodies. The introduction of pharmacological agents that are able to inhibit EGFR represents an important step in the management of patients with advanced non-small cell lung cancer (NSCLC), the leadi
Revista da Associação Médica Brasileira. Publicado em: 2012-04
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16. Epidermal growth factor receptor and KRAS mutations in Brazilian lung cancer patients
OBJECTIVE: Epidermal growth factor receptor is involved in the pathogenesis of non-small cell lung cancer and has recently emerged as an important target for molecular therapeutics. The KRAS oncogene also plays an important role in the development of lung cancer. The aim of this study was to evaluate the frequency of epidermal growth factor receptor and KRAS
Clinics. Publicado em: 2012
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17. Immunohistochemical expression of p63, epidermal growth factor receptor (EGFR) and notch-1 in radicular cysts, dentigerous cysts and keratocystic odontogenic tumors
O objetivo deste estudo foi avaliar a expressão imunoistoquímica da proteína p63, receptor do fator de crescimento epidérmico (EGFR) e Notch-1 no revestimento epitelial de cistos radiculares (CR), cistos dentígeros (CD) e tumores odontogênicos queratocísticos (TOQ). Para este estudo, 35 CR, 22 CD e 17 TOQ foram utilizados. Os dados clínicos e epidemi
Braz. Dent. J.. Publicado em: 2012
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18. Immunohistochemical expression of the epidermal growth factor receptor (EGFR) in colorectal carcinoma: relation with clinicopathological parameters
Introdução: O estudo da imunoexpressão tecidual do receptor do fator de crescimento epitelial (EGFR) pode contribuir para o entendimento de seu papel no prognóstico do carcinoma colorretal. Objetivo: Analisar a expressão imuno-histoquímica do EGFR no carcinoma colorretal e nos tecidos da transição tumor-mucosa e da mucosa adjacente à neoplasia, e av
Journal of Coloproctology (Rio de Janeiro). Publicado em: 2011-09
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19. Expressão do RNAm do kit ligand (KL), proteína morfogenética óssea 15 (BMP-15) e fator de crescimento epidermal (EGF) e efeito das respectivas proteínas sobre o desenvolvimento in vitro de folículos pré-antrais caprinos. / MRNA expression of kit ligand (KL), bone morphogenetic protein 15 (BMP 15) and epidermal growth factor (EGF) and their effect on the protein in vitro development of caprine preantral follicles.
Os objetivos deste estudo foram: 1) quantificar os níveis de RNAm para o kit ligand (KL), proteína morfogenética óssea 15 (BMP-15) e fator de crescimento epidermal (EGF) em ovários caprinos através da técnica de RT-PCR em tempo real; 2) avaliar o efeito da adição de diferentes concentrações destas substâncias sobre a sobrevivência, ativação e
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 13/12/2010
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20. Triple-negative breast carcinomas are a heterogeneous entity that differs between young and old patients
OBJECTIVE: To compare the frequency and immunohistochemical profiles of triple-negative breast carcinomas in younger and older women. METHODS AND RESULTS: We selected patients diagnosed with triple-negative breast carcinomas. The groups examined were women who were 35 years old or younger between 1997 and 2007 (n = 74) and, for comparison, women who were 60
Clinics. Publicado em: 2010
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21. Análise da expressão do receptor do fator de crescimento epitelial (EGFR) em pacientes portadores de adenocarcinoma pancreático submetidos a tratamento cirúrgico com intuito curativo / EGFR expression in pancreatic cancer patients submitted to surgical resection
INTRODUCTION: Pancreatic cancer is one of the main cancer related deaths in the world and its incidence is similar to its mortality. Biological aggressiveness and delayed diagnosis are a major concern. Adjuvant treatment has little impact on survival and the expression of potential target molecules has been undertaken in order to increase survival. OBJECTIVE
Publicado em: 2010
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22. Leucoplasia oral: tratamento cirúrgico com laser de CO2 e de diodo e análise por imuno-histoquímica da expressão de proteínas relacionadas à carcinogênese (p53, COX-2 e EGFR) / Oral leukoplakia: surgical treatment with CO2 and diode lasers and analysis of the expression of proteins related to carcinogenesis (p53, COX-2 e EGFR) by immunohistochemistry
Oral leukoplakia (OL) is a potentially malignant lesion, defined as a white patch that cannot be characterized as any other disease of the oral mucosa. In general, OL should be treated; however no treatment available has been able to prevent malignant transformation. The aim of this study was to evaluate the efficacy of surgical treatment with CO2 and diode
Publicado em: 2010
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23. Epidermal growth factor receptors, testosterone levels and parotid gland changes in rats infected with Trypanosoma cruzi
It has been demonstrated that parotid glands of rats infected with Trypanosoma cruzi present severe histological alterations; changes include reduction in density and volume of the acini and duct systems and an increase in connective tissue. We evaluated the association between morphological changes in parotid glands, circulating testosterone levels and epid
Memórias do Instituto Oswaldo Cruz. Publicado em: 2009-08
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24. The role of diet, transforming growth factor alpha and epidermal growth factor receptor in the cell proliferation and differentiation during the postnatal development of the gastric epithelium of rats. / O papel do alimento, do fator de crescimento transformante alfa e do receptor do fator de crescimento epidermal na proliferação e diferenciação celular durante o desenvolvimento pós-natal do epitélio gástrico de ratos.
Early weaning (EW) causes changes in the gastric mucosa, including the increase in cell proliferation and Transforming Growth Factor (TGFa). In the present study, we evaluated the role of this peptide and its receptor EGFR in the control of the gastric growth. 15-d-old rats were divided into two groups: suckling (control) and EW, in which the pups were separ
Publicado em: 2009