Endothelins 1
Mostrando 1-12 de 21 artigos, teses e dissertações.
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1. Participação da endotelina-1 na sinovite induzida por carragenina na articulação temporomandibular de ratos. / Endothelin-1 participation on the rats temporomandibular joint synovitis induced by carrageenan.
Disfunções temporomandibulares são secundárias à inflamação e dor. Estudos mostram a participação da ET na nocicepção. Investigamos o papel da ET1 na sinovite induzida pela injeção de CGN na ATM de ratos. Injeções intra-articulares de CGN, ET1 ou do agonista do receptor ETB BQ3020 foram realizadas na ATM. Após 4h, a hiperalgesia foi avaliada
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/05/2012
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2. Lesão causada pela isquemia seguida de reperfusão em modelo experimental de transplante de intestino em porcos jovens: avaliação por meio de métodos histológicos, imunoistoquímicos e de biologia molecular / Experimental model of intestinal transplantation in pigs: evaluation of the ischemia reperfusion injury by means of histological, and immunohistochemical methods and molecular biology
INTRODUÇÃO: O transplante de intestino (TI) estabeleceu-se como tratamento para pacientes com falência intestinal e complicações da nutrição parenteral. Entretanto, sepse continua sendo a principal causa de mortalidade. A lesão causada pela isquemia seguida de reperfusão (LIR) é apontada como um dos fatores de ruptura da barreira mucosa intestinal,
Publicado em: 2011
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3. Modulation of rhodopsin gene expression and signaling mechanisms evoked by endothelins in goldfish and murine pigment cell lines
Endothelins (ETs) and sarafotoxins (SRTXs) belong to a family of vasoconstrictor peptides, which regulate pigment migration and/or production in vertebrate pigment cells. The teleost Carassius auratus erythrophoroma cell line, GEM-81, and Mus musculus B16 melanocytes express rhodopsin, as well as the ET receptors, ETB and ETA, respectively. Both cell lines a
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-09
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4. Expressão gênica e protéica de rodopsina em células pigmentares e mecanismos de sinalização intracelular da sua modulação por endotelinas / Modulation of rhodopsin expression and signaling mechanisms evoked by endothelins in in pigment cell lines
Endothelins (ETs) and sarafotoxins (SRTXs) belong to a family of vasoconstrictor peptides, which can regulate pigment migration and/or production in vertebrate pigment cells (chromatophores). In teleostean fish, ETs/SRTXs induce pigment migration. In human melanocytes, ETs promote melanogenesis and mitogenesis. ETs also regulate the transcription of several
Publicado em: 2009
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5. Paradoxical sleep deprivation increases plasma endothelin levels
The endothelins (ET-1, 2 and 3) constitute a family of 21 amino acid peptides with potent biological activities. ET-1 is one of the most potent endogenous vasoconstrictors so far identified and its increased concentration in plasma appears to be closely related to the pathogenesis of arterial hypertension as well as to obstructive sleep apnea (OSA). OSA pati
Brazilian Journal of Medical and Biological Research. Publicado em: 2002-01
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6. Caracterização farmacologica dos receptores de endotelina na circulação portal de figado isolado de cão
Endothelins constitute a family of vasoactive mediators, capable of producing potent and long-lasting pressor responses in several vascular territories. Endothelin-1 has been implicated in the regulation of resistance to portal blood flow, particularly in the presence of cirrhosis and portal hypertension. However, the receptor subtypes mediating this phenome
Publicado em: 1997
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7. Endogenous endothelins mediate increased distal tubule acidification induced by dietary acid in rats.
We examined if endogenous endothelins mediate the decreased HCO3 secretion and increased H+ secretion in in vivo-perfused distal tubules of rats fed dietary acid as (NH4)2SO4. Animals given (NH4)2SO4 drinking solution had higher endothelin-1 addition to renal interstitial fluid than those given distilled H2O (480+/-51 vs. 293+/-32 fmol g kidney wt(-1) min(-1
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8. Endothelins are more sensitive than sarafotoxins to neutral endopeptidase: possible physiological significance.
Incubation of endothelins (ETs) with bovine kidney neutral endopeptidase (NEP) resulted in a selective two-step degradation with loss of biochemical activity. The Km of the enzyme indicated high-affinity binding, and hydrolysis was completely inhibited by phosphoramidon. The first step was nicking of the Ser5-Leu6 bond, followed by cleavage at the amino side
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9. Serum Response Factor-GATA Ternary Complex Required for Nuclear Signaling by a G-Protein-Coupled Receptor
Endothelins are a family of biologically active peptides that are critical for development and function of neural crest-derived and cardiovascular cells. These effects are mediated by two G-protein-coupled receptors and involve transcriptional regulation of growth-responsive and/or tissue-specific genes. We have used the cardiac ANF promoter, which represent
American Society for Microbiology.
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10. Ontogeny of endothelins-1 and -3, their receptors, and endothelin converting enzyme-1 in the early human embryo.
The targeted gene inactivation of endothelins-1 and -3 (ET-1 and ET-3) and of one of their receptors, ETB, in the mouse causes severe defects in the embryonic development. These defects, cardiovascular and craniofacial malformations for ET-1, and colonic agangliogenesis associated with skin pigmentation anomalies for ET-3 and the ETB receptor, reproduce path
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11. Endothelin receptor subtype B mediates synthesis of nitric oxide by cultured bovine endothelial cells.
Endothelins (ET) produce endothelium-dependent vasodilation through nitric oxide (NO) synthesis. The present study was designed to elucidate the cellular mechanism by which ET induces synthesis and release of endothelium-derived NO by cultured bovine endothelial cells (EC). Binding studies revealed that bovine EC membrane had the binding sites of a novel ago
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12. Sculpting organ innervation
Neurotrophic growth factors, including nerve growth factor (NGF) and glial-derived neurotrophic factor (GDNF), have well-established roles in promoting the innervation of target tissues, yet little is known about how the temporal and organ-specific expression of these factors is regulated. A new study reveals that NGF is a direct target of the well-character
American Society for Clinical Investigation.