Enantioselectivity
Mostrando 13-24 de 60 artigos, teses e dissertações.
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13. Aplicação da microextração em fase liquida na análise de alguns fármacos antimaláricos e respectivos metabólitos em plasma / Application of liquid-phase microextration to the analysis of some antimalarial drugs and their metabolites in plasma
Currently, malaria is the main parasitic infection and shows worldwide distribution. Among therapeutic options used, chloroquine (CQ), mefloquine (MQ) and, more recently, artemether (ART) have been standing out. According to the literature, pharmacokinetic studies of these drugs have been hampered by the lack of proper methods of analysis in biological fluid
Publicado em: 2009
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14. Influência da inalação de metanol na farmacocinética enantiosseletiva da fluvastatina em ratos / Inalation influence of methanol on the pharmacokinetics enantiosselective of fluvastatin in rats.
Dislipidemia is one of the main causes of cardiovascular illness and very frequent in the adults population. Fluvastatin, a racemic mixture of the (-)-3S,5R and (+)-3R,5S enantiomers, has been shown to be a potent competitive inhibitor of HMGCoA reductase used in the hypercholesterolemia treatment and with elimination in the man essentially dependent of the
Publicado em: 2008
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15. Produção de cutinase por fusarium oxysporum utilizando sub-produtos agroindustriais / Cutinase production by fusarium oxysporum utilizing agro-industrial by products
Cutinases são enzimas amplamente encontradas na natureza, podendo ser obtidas de fontes vegetais ou microorganismos. Trata-se de uma esterase que atua tanto como esterase quanto como lipase, capaz de hidrolisar uma ampla variedade de ésteres sintéticos e triglicerídeos. Este perfil de atividade oferece-lhe um número de aplicações importantes nas indú
Publicado em: 2008
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16. Enantiosseletividade no metabolismo do citalopram associado a inibidores do CYP: estudos clínicos e experimental / Enantioselectivity in the metabolism of citalopram combined with CYP inhibitors: clinical and experimental studies
Citalopram (CITA), a selective serotonin reuptake inhibitor, is available for clinical use as a racemic mixture of the (+)-(S) and (-)-(R) enantiomers or as the pure (+)-(S)-CITA enantiomer. CITA is metabolized by CYP2C19, CYP2D6 and CYP3A to demethylcitalopram (DCITA) and by CYP2D6 to didemethylcitalopram. The present study investigated the influence of enz
Publicado em: 2007
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17. Estudo da oxidação de sulfetos pró-quirais com oxo diperoxo complexos de molibdênio (VI) / Oxidation study of prochiral sulfides with oxo diperoxo Molybdenum (vi) complexes
This study describes the use of oxo diperoxo molybdenum (VI) complex using 2,2-bipyridine and N,N-dioxide-2,2-bipyridine as ligands for the oxidation of a series of aliphatic and aromatic sulfides, ketosulfides, sulfinyl acids and olefinic sulfides. The preparation of these complexes, the reactivity and the chemeoselectivity in these sulfides oxidation react
Publicado em: 2007
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18. Aplicação de triagem de alto desempenho na investigação das atividades enzimaticas e enantiosseletividades de microorganismos brasileiros / Enzymatic activities and Quick E in hydrolases screening appyng fluorescent probes
Nas últimas décadas as reações utilizando biocatalisadores tem sido amplamante aplicadas na síntese orgânica, como componentes chave de muitos processos químicos industriais, levando ao aumento na demanda por novas enzimas. A maneira mais rápida e simples de detectar enzimas é através de metodologias de triagem de alto desempenho (HTS) que permitam
Publicado em: 2007
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19. Multibiorreações e suas aplicações para as sinteses de compostos enantiomericamente puros / Multibioreactions applied to the syntheses of enantiomerically pure compounds
The utilization of enzymes for organic compound transformations is an alternative to classical syntheses. Enzymes are used as biocatalysts for the syntheses in vitro of asymmetric compounds because they are intrinsically chiral and result in high catalytic efficiency. In front of the biodiversity of existing microorganisms in Nature and of the necessity to d
Publicado em: 2006
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20. Potencial de biocatálise enantiosseletiva de lipases microbianas
Microbial lipases have a great potential for commercial applications due to their stability, selectivity and broad substrate specificity because many non-natural acids, alcohols or amines can be used as the substrate. Three microbial lipases isolated from Brazilian soil samples (Aspergillus niger; Geotrichum candidum; Penicillium solitum) were compared in te
Química Nova. Publicado em: 2005-08
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21. Sintese enzimatica dos esteres de aroma butirato e valerato de citronelila por lipase de Rhizopus sp. / Enzymatic synthesis of the butyric flavor esters and valeric citronellyl by lipase of Rhizopus sp.
The enzymatic synthesis of citronellyl flavor esters with a non commercial lipase from Rhizopus sp was investigated. The results were compared with other lipases from Fusarium 152 B, Fusarium 160 A1, Tricoderma sp, and Alcaligenes sp. The lipase from Rhizopus sp was selected as better biocatalyst for the citronelyl ester synthesis. It was verified the effect
Publicado em: 2004
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22. A Interação substrato-modificador e sua importância para a hidrogenação enantiosseletiva de alfa-cetoésteres
The heterogeneous asymmetric catalysis plays an important and crucial role in many chemical processes and has therefore become a growing and interesting field. The enantioselective hydrogenation of α-ketoesters is one of the best known examples of such process. Methyl pyruvate, which can be converted to (R)- and (S)-methyl lactate with an enantioselecti
Publicado em: 2004
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23. Isolamento e seleção de microrganismos brasileiros para reações de biocatalise e produção de metabolitos
This thesis is a pioneer work at the Chemistry Institute/UNICAMP, consisting of a preliminary investigation of a Brazilian Culture Collection biocatalitic potential (Coleção de Culturas Tropical ,CCT, Fundação Tropical de Pesquisas "André Tosello") 13 different microorganisms from the above mentioned collection were evaluated: fungi (Aspergillus niger C
Publicado em: 2002
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24. Preparação, caracterização e avaliação de catalisadores heterogeneos a base de Pt na hidrogenação enantiosseletiva do piruvato de metila em presença de cinconidina
Platinum based catalysts were prepared by impregnation on different supports, namely C, Al303, TiO2 and La203. The commercial activated carbon was oxidized by different methods in order to modify its surface. The main surface groups identified were carboxylic acid, when HN03 is the oxidizing agent, and carbonyl, phenol and quinone, when the oxidation is made
Publicado em: 2000