Drug Product Quality Control
Mostrando 1-12 de 22 artigos, teses e dissertações.
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1. Development and Validation of a Stability-Indicating Method for Perillyl Alcohol Incorporated in Poly(lactide-co-glycolide) Nanoparticles and Stress Degradation Studies
Perillyl alcohol has been studied in the treatment of cancer disease. However, its high toxicity is a drawback, which can be overcome by its incorporation in nanostructured systems. The aim of this work was to develop and validate a chromatographic method for determination of perillyl alcohol encapsulation efficiency in a polymeric nanoparticles formulation
J. Braz. Chem. Soc.. Publicado em: 2017-12
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2. Morphoanatomical and physicochemical profile of Piper callosum: valuable assessment for its quality control
ABSTRACT Piper callosum Ruiz & Pav., Piperaceae, popularly known as “elixir-paregórico” and “matricá” in Brazil, is used in folk medicine to treat gonorrhea, general pain, and digestive disorders, and has repellent, astringent, diuretic, depurative, and haemostatic properties. Despite the fact that this plant is sold as a traditional phytotherapeut
Rev. bras. farmacogn.. Publicado em: 2017-02
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3. Validation of a spectrophotometric methodology for the quantification of polysaccharides from roots of Operculina macrocarpa (jalapa)
The roots from Operculina macrocarpa (L.) Urb., Convolvulaceae, are widely used in Brazilian traditional medicine as a laxative and purgative. The biological properties of this drug material have been attributed to its polysaccharides content. Thus, the aim of this study was to evaluate the polysaccharide content in drug material from O. macrocarpa by spectr
Rev. bras. farmacogn.. Publicado em: 2014-12
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4. Evaluation of hard gelatin capsules and hydroxypropyl methylcellulose containing ampicillin
This study aims to develop and evaluate formulations containing ampicillin in capsules of gelatin and hydroxypropyl methylcellulose (HPMC). Two formulations (A and B) were developed. The final product quality was evaluated by testing for quality control and the results were in agreement with the Brazilian Pharmacopoeia. The formulations with HPMC capsules sh
Química Nova. Publicado em: 2012
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5. Spectrophotometric and spectrofluorimetric determination of some drugs containing secondary amino group in bulk drug and dosage forms via derivatization with 7-Chloro-4-Nitrobenzofurazon
Sensitive and selective spectrophotometric and spectrofluorimetric methods have been developed for determination of some drugs such as Pramipexole, Nebivolol, Carvedilol, and Eletriptan, which commonly contain secondary amino group. The subject methods were developed via derivatization of the secondary amino groups with 7-Chloro-4-Nitrobenzofurazon in borate
Química Nova. Publicado em: 2011
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6. Controle de qualidade e avaliação das propriedades tecnológicas das formas polimórficas de talidomida / Quality control and evaluation of technological properties of polymorphic forms of thalidomide
Thalidomide was widely prescribed between 1950 and 1960, in nearly 50 countries, as sedative and antiemetic for morning sickness during pregnancy. After the occurrence of serious problems of teratogenicity it was heavily controlled. Growing interest has been observed in recent years to identify and elucidate the anti-inflammatory, immunomodulatory and anti-a
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2011
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7. Eletrophoretic and spectrometric characterization of Cinchona extracts of use phytoterapic and cosmetic / Caracterização eletroforética e espectrométrica de extratos de Cinchona de uso fitoterápico e cosmético
Every year, malaria kills about one million people. According to OMS, 3.3 billion people, half of the world population, are exposed to the disease, mostly in underdeveloped countries. The pharmaceuticals used in the treatment of malaria include: chloroquine, primaquine, quinine, mefloquine, doxyclyne, clindamicina and artemisin. The increased resistance of t
Publicado em: 2010
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8. Metodologia analítica aplicada ao controle de qualidade do antifúngico cloridrato de butenafina na forma de creme e à avaliação da sua penetração cutânea in vitro / Analytical methodology applied to the quality control of the antifungal butenafine hydrochloride in cream formulation and to the analysis of its penetration in vitro
Objectives: The aim of the present work was to develop, validate and compare stability indicating methods to quantify butenafine hydrochloride (BTF), raw material and commercial cream, as well as to establish the degradation kinetics of the drug in a stress condition. Also, the study had the goal of validating a method to assess and compare the cutaneous per
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2010
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9. Identificação dos riscos sanitários na manipulação de medicamentos alopáticos não estéreis em farmácia comunitária e o papel das boas práticas de manipulação no controle desses riscos / Identification of sanitary risks related to the pharmaceutical compounding of non-sterile drug products in community pharmacy and the role of Good Compounding Practices in controlling these risks
Pharmaceutical compounding is the essence of pharmaceutical profession. Compounded drug products are addressed to an individual patient and for this reason they are considered an important tool in therapeutics. However, the literature states that the absence of scientific confirmation of clinical safety and efficacy, as required to the manufactured drug prod
Publicado em: 2009
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10. Separação dos enatiômeros do cetoprofeno e do fenoprofeno por CLAE em fase estacionária quiral / Separation of ketoprofen and fenoprofen enantiomers by HPLC using chiral stationary phase
Durante muito tempo, os fármacos quirais de origem sintética foram comercializados predominantemente como racematos. Atualmente, sabe-se que os enantiômeros de um fármaco quiral podem apresentar propriedades farmacocinéticas, farmacodinâmicas e toxicológicas bastante distintas. Assim sendo, técnicas analíticas enantiosseletivas são fundamentais par
Publicado em: 2008
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11. HIV/AIDS treatment and physicochemical quality control of medicines: evaluation of non-generic lamivudine + zidovudine tablets manufactured in Brazil
In this work it was evaluated the physicochemical quality of lamivudine + zidovudine tablets, whose association belongs to the list of drugs distributed by the Brazil's National Program on Sexually Transmitted Diseases and AIDS. Four non-generic products (lamivudine + zidovudine tablets) were analyzed. They were obtained from different Brazilian manufacturer
Brazilian Journal of Infectious Diseases. Publicado em: 2007-12
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12. CaracterizaÃÃo e desenvolvimento de mÃtodos analÃticos do ornidazol
The nitroimidazoles drugs acts to inhibit the synthesis of microbial DNA, this class presents the metronidzole as drug of choice. The ornidazol, derivative of the 5-nitroimidazoles, presents therapeutic advantages in relation to metronidazole, by presenting a bigger half-life, causing the reduction in the dosage frequency and the duration of the treatment in
Publicado em: 2007