Drug Oxidation
Mostrando 13-24 de 94 artigos, teses e dissertações.
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13. Degradação de abamectina por processos oxidativos avançados / Abamectin degradation by advanced oxidative processes
A abamectina é uma avermectina amplamente utilizada como antiparasitário na pecuária. Os processos selecionados para degradação do fármaco veterinário foram fotólise (UV), peroxidação (H2O2), peroxidação assistida por luz ultravioleta (UV/H2O2), reagente de Fenton e foto-Fenton. A concentração inicial de abamectina foi de 500 ?g L-1 e cada ensa
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/02/2012
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14. O ß-hidroxibutirato modifica os processos de ativação e inativação dos canais para sódio e potássio em corpos celulares de neurônios dos gânglios das raizes dorsais de ratos.
Under physiological conditions, the ketone bodies -hydroxybutyrate, acetoacetate and acetone are products of -oxidation of fatty acids that occurs in hepatocytes in response to hypoglycemia. This process occurs during fasting, high fat diets (such as the ketogenic diet, used in cases of drug-resistant epilepsy) and during diabetes mellitus in order to meet t
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 20/12/2011
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15. Otimização do processo de mineralização de compostos orgânicos utilizando sistemas eletro-Fenton e fotoeletro Fenton por irradiação UV artificial e solar
OPTIMIZATION OF THE MINERALIZATION PROCESS OF ORGANIC COMPOUNDS USING ELECTRO-FENTON AND PHOTO-FENTON SYSTEMS BY ARTIFICIAL AND SOLAR UV IRRADIATION Electrochemical advanced oxidation processes based on the Fentons reaction, such as electro-Fenton (EF) and photoelectro-Fenton (PEF) using artificial and solar UV irradiation were employed in the treatment of e
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/09/2011
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16. Avaliação dos efeitos do ultrassom terapêutico sobre a cafeína e verificação da liberação em sistema de difusão vertical
Currently, the physiotherapists use the phonoforesis, which consists in the therapeutical ultrasound (US) used to increase the drug molecules migration through the skin, however, the US can shows oxidative effects, and is used, for example, in chemical reactions acceleration. The present study aimed to perform the electrochemical evaluation and the diffusion
Química Nova. Publicado em: 2011-09
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17. Proteção por L-carnitina ou piracetam contra a morte celular causada por sinvastatina em celulas tumorais e não tumorais / Protection by L-carnitine or piracetam against cell death caused by simvastatin in tumor and non tumorigenic cell lines
Statins are drugs widely used in the treatment of hypercholesterolemia. They are competitive inhibitors of 3-hydroxy 3-methylglutaryl coenzyme A (HMG-CoA) reductase preventing in this way, the synthesis of cholesterol. L-carnitine is synthesized from the essential aminoacids lysine and methionine in liver and kidney and plays na important role in the cell, w
Publicado em: 2010
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18. Relação entre a Síndrome Metabólica, teor de gordura intramiocelular e os níveis plasmáticos da Adiponectina: papel da Rosiglitazona / Relationship between the Metabolic Syndrome, intramyocellular fat and plasma Adiponectin: role of Rosiglitazone
Insulin resistance (IR) is associated with intramyocellular lipid (IMCL) content and low serum adiponectin (ADP) levels. ADP is also involved in muscle fat oxidation but the relationship between them is still controversial. We aimed to further explore the relationship between ADP and IMCL content in non-diabetic adults and the role of rosiglitazone (RSG) in
Publicado em: 2009
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19. Evaluation of the protective effect of carvedilol against the renal mitochondrial toxicity induced by cisplatin in rats / Avaliação do efeito protetor do carvedilol na toxicidade mitocondrial renal induzida pela cisplatina em ratos
Cisplatin (cis-diamminedichloridoplatinum II) is an affective anticancer agent; however its clinical use is highly limited, predominantly due to its nephrotoxicity. Many studies have shown that cisplatin cause mitochondrial dysfunction in renal epithelial cells due to the generation of reactive oxygen species, such as superoxide anions and hydroxyl radicals.
Publicado em: 2009
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20. Desenvolvimento de procedimentos em fluxo para a determinação de Captopril, Dipirona e Paracetamol envolvendo multicomutação e inibição da quimiluminêscencia / Development of procedures in flow injection for the determination of captopril, dipirona and paracetamol involving multicommutation and inhibition of chemiluminescencia
In the present work, analytical procedures were developed using the multicomutação concept and inhibition of the chemilumenescence for the pharmaceuticals determination, such as, captopril, dipirona and paracetamol. For the control of the analysis module and acquisitions of data a microcomputer was used Pentiun 233 MHz equipped with an electronic interface
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 20/02/2008
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21. Metalloporphyrins and salen complexes as a P450 biomimetic model for the metabolism of antiepileptic and antidepressant drugs / Metaloporfirinas e compostos salen como modelos biomiméticos do citocromo P450 no metabolismo de fármacos anticonvulsivante e antidepressivo
In this work, the catalytic activities of metalloporphyrins and the salen complex (Jacobsen catalyst) in solution and immobilized on different supports were studied in the oxidation of hydrocarbons, anticonvulsivant drugs (carbamazepine and primidone) and antidepressives (fluoxetine) by the following oxygen donors: hydrogen peroxide, terc-butyl hydroperoxide
Publicado em: 2008
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22. Highly sensitive spectrophotometric methods for the determination of olanzapine
Highly sensitive and selective spectrophotometric methods (A and B) were developed for the determination of micro amounts of olanzapine (OLZ). Method A (direct method) is based on the oxidation of olanzapine with a known excess of iodine monochloride (ICl) in an acidic medium. Under the same condition, thymol blue was iodinated by unreacted ICl, and the abso
Eclética Química. Publicado em: 2008
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23. Partial caracterization of dipyridamole electrooxidation products in acetonitrile and acid aqueous medium / Caracterização parcial dos produtos de eletrooxidação do dipiridamol em acetonitrila e em meio aquoso ácido
In this work the products obtained in the eletrooxidation reactions of 2,6- bis(diethanolamino)-4,8-dipiperidinopyrimido-[5,4-d] pyrimidine (Dipyridamole) were studied. Dipyridamole is a drug that induce the coronary vasodilatation mostly used in Nuclear Cardiology in different techniques based on acquisition and image processing ( perfusion heart cintilogra
Publicado em: 2008
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24. Cerimetric determination of simvastatin in pharmaceuticals based on redox and complex formation reactions
Two sensitive spectrophotometric methods are described for the determination of simvastatin (SMT) in bulk drug and in tablets. The methods are based on the oxidation of SMT by a measured excess of cerium (IV) in acid medium followed by determination of unreacted oxidant by two different reaction schemes. In one procedure (method A), the residual cerium (IV)
Eclética Química. Publicado em: 2008