Drug Oxidation
Mostrando 1-12 de 94 artigos, teses e dissertações.
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1. Development and Validation of a Gas Chromatographic Method for the Quantification of Minor Alkaloids in Cocaine
The quantification of minor alkaloids in seized cocaine can provide information for drug profiling and law enforcement initiatives. This work presents the development and validation of an analytical method to quantitate minor alkaloids in cocaine samples using gas chromatography with flame ionization detector, after derivatization. The method was validated i
J. Braz. Chem. Soc.. Publicado em: 2021-04
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2. Preformulation of a liquid dosage formulation of captopril for pediatric use: drug-excipient compatibility and stability studies
Currently, medications used in children are typically modified from pharmaceutical dosage forms designed for adults. Captopril is widely adapted to liquid formulations for use in hospitals. Its stability in the aqueous medium is reduced since it undergoes oxidation producing captopril disulfide (its main metabolite). The aim of this formulation study was to
Braz. J. Pharm. Sci.. Publicado em: 20/12/2019
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3. Development and validation of a stability-indicating LC-UV and LC-MS/MS methods for quantitative analysis of anisomycin and identification of degradation products
ABSTRACT Multifunctional drug anisomycin was subjected to forced degradation in accordance with International Conference on Harmonisation (ICH) guidelines for the first time. The drug was exposed to the recommended stress conditions of hydrolysis (acidic, alkaline and neutral), oxidation, thermal stress and photolysis, in order to investigate its stability.
Braz. J. Pharm. Sci.. Publicado em: 26/07/2018
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4. Development and Validation of a Stability-Indicating Method for Perillyl Alcohol Incorporated in Poly(lactide-co-glycolide) Nanoparticles and Stress Degradation Studies
Perillyl alcohol has been studied in the treatment of cancer disease. However, its high toxicity is a drawback, which can be overcome by its incorporation in nanostructured systems. The aim of this work was to develop and validate a chromatographic method for determination of perillyl alcohol encapsulation efficiency in a polymeric nanoparticles formulation
J. Braz. Chem. Soc.. Publicado em: 2017-12
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5. A Sensitive Voltammetric Determination of Anti-Parkinson Drug Pramipexole Using Titanium Dioxide Nanoparticles Modified Carbon Paste Electrode
In this study, a facile sensor based on TiO2 nanoparticles modified carbon paste electrode was developed for voltammetric determination of pramipexole in pharmaceutical formulations and biological samples. Surface of the fabricated electrode have been characterized using field emission scanning electron microscopy. Under the optimized experimental conditions
J. Braz. Chem. Soc.. Publicado em: 2017-04
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6. Neurobiochemical mechanisms of a ketogenic diet in refractory epilepsy
A ketogenic diet is an important therapy used in the control of drug-refractory seizures. Many studies have shown that children and adolescents following ketogenic diets exhibit an over 50% reduction in seizure frequency, which is considered to be clinically relevant. These benefits are based on a diet containing high fat (approximately 90% fat) for 24 mon
Clinics. Publicado em: 2014-12
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7. Phenolic extract of Parkia biglobosa fruit pulp stalls aflatoxin B1 – mediated oxidative rout in the liver of male rats
The effect of phenolic extract of Parkia biglobosa (Jacq.) R. Br. ex G. Don, Fabaceae, pulp on aflatoxin B1 induced oxidative imbalance in rat liver was evaluated. Thirty-five male rats were randomized into seven groups of five animals each. Rats in group A served as control and received vehicle for drug administration (0.5% DMSO) once daily at 24 h interval
Rev. bras. farmacogn.. Publicado em: 2014-12
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8. Elastic modulus evaluation of Titania nanotubes obtained by anodic oxidation
The use of titania (TiO2) nanotubes is becoming one of the most attractive techniques as surface treatment for implants due its combination of morphology (that accelerates osteoblast adhesion and proliferation), bioactivity and possibility of being use as a drug vehicle. Anodic oxidation is one of the cheapest and simplest approaches to obtain highly ordere
Matéria (Rio J.). Publicado em: 2014-03
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9. Remoção do ácido mefenâmico em água utilizando carvão ativado em pó, lama vermelha e oxidação com cloro
The use of activated carbon powder (ACP), red mud and oxidation with chlorine to remove mefenamic acid in water are described, aimed at their application as a complement to sewage treatment processes in Brazil. A study on the behavior of mefenamic acid in water was performed by evaluating its dissolution for different concentrations and times. Subsequently,
Quím. Nova. Publicado em: 2014
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10. Determination of anti-cancer drug emodin using a silica-gel-modified carbon paste electrode
In this paper, a silica-gel-modified carbon paste electrode (Si-gel/CPE) was used to determine the anti-cancer drug emodin by anodic stripping differential pulse voltammetry (ASDPV). The effects of the silica-gel content, the pH of the supporting electrolyte, and the scan rate on the oxidation current of emodin were investigated. The oxidation currents of em
Quím. Nova. Publicado em: 2014
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11. Kinetics and mechanism of oxidation of the drug intermediate 1-(2-Hydroxyethyl)piperidine by Bis(hydrogenperiodato)argentate(III)
1-(2-Hidroxietil)piperidina (HEP) está presente em muitos fármacos e em protótipos de fármacos, mas seus mecanismos de oxidação são mal compreendidos. Assim, a reação de oxidação da HEP pelo bis(hidrogenoperiodato)-argentato(III) ([Ag(HIO6)2]5-;) foi investigada em meio alcalino aquoso. Piperidina e formaldeído foram identificados como principais
J. Braz. Chem. Soc.. Publicado em: 2013-08
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12. Blendas e filmes de quitosana/amido de milho: estudo da influência da adição de polióis, oxidação do amido e razão amilose/amilopectina nas suas propriedades / Chitosan/corn starch blends and films. Influence of polyol addition, starch oxidation and amylose/amylopectin ratio in their properties
Chitosan/starch association represents an interesting alternative to the preparation of biocompatible drug delivery systems, packing materials and edible films. Changes in rheological, thermal and mechanical properties, water vapor permeability and solubility of chitosan/starch films were evaluated varying the starch structure form (gelatinized or oxidized),
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/02/2012