Drug Delivery
Mostrando 13-24 de 663 artigos, teses e dissertações.
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13. Access to high-cost medications for psoriatic arthritis in the National Health System in Brazil: the long path up to dispensation
Abstract Background: Pharmaceutical Assistance (PA) is a dynamic and multidisciplinary process that aims to supply health systems, programs or services with quality medicines, enabling access and health care, in an efficient and timely manner. The objective of the study was to evaluate the profile of administrative processes for the treatment of PsA, identi
Adv. rheumatol.. Publicado em: 28/11/2019
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14. Preparation and properties of α-tricalcium phosphate microspheres by spray drying
Resumo Microesferas de α-TCP foram obtidas atomizando uma suspensão aquosa contendo 50% em massa de α-TCP com baixa cristalinidade e 1% em massa de ácido cítrico. Poli(etileno glicol) e poli(álcool vinílico) foram testados como ligantes. O processo de spray drying resultou em microesferas com diâmetros médios de aproximadamente 20 μm e esfericidade
Cerâmica. Publicado em: 14/11/2019
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15. Unique heterologous fibrin biopolymer with hemostatic, adhesive, sealant, scaffold and drug delivery properties: a systematic review
Abstract Fibrin biopolymers, previously referred as “fibrin glue” or “fibrin sealants”, are natural biomaterials with diverse applications on health. They have hemostatic, adhesive, sealant, scaffold and drug delivery properties and have become widely used in medical and dental procedures. Historically, these biomaterials are produced from human fibr
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 11/11/2019
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16. Fibrin biopolymer as scaffold candidate to treat bone defects in rats
ABSTRACT Background: Bone tissue repair remains a challenge in tissue engineering. Currently, new materials are being applied and often integrated with live cells and biological scaffolds. The fibrin biopolymer (FBP) proposed in this study has hemostatic, sealant, adhesive, scaffolding and drug-delivery properties. The regenerative potential of an associat
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 04/11/2019
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17. Solid dispersion-based pellet for colon delivery of tacrolimus through time- and pH-dependent layer coating: preparation, in vitro and in vivo studies
The intent of the present investigation is to develop and evaluate colon-specific coated tacrolimus solid dispersion pellet (SDP) that retards drug release in the stomach and small intestine but progressively releases in the colon. Tacrolimus-SDP was prepared by extrusion-spheronization technology and optimized by the micromeritic properties including flowab
Braz. J. Pharm. Sci.. Publicado em: 24/10/2019
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18. Application of Glycerol in the Synthesis of Hyperbranched and Highly Branched Polyethers: Characterization, Morphology and Mechanism Proposal
Hyperbranched biopolymers is an important class of polymer that is used in different areas, mainly in biomedicine. AB2 monomers are crucial to the development of a "hyperbranched" architecture of polyglycerol, being glycidol the most commonly used, even considering its environmental hazard. Glycerol carbonate is an ecologically accepted monomer synthesized d
Mat. Res.. Publicado em: 24/10/2019
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19. Magneto-Responsive Hydrogels: Preparation, Characterization, Biotechnological and Environmental Applications
Hydrogels are hydrophilic three-dimensional networks able to hold large amount of water and hydrophilic molecules. Magneto-responsive hydrogels comprise of magnetic nanoparticles dispersed in polymeric networks that can be manipulated under external magnetic field. This review aims at (i) giving a brief overview on the evolution of hydrogels until the design
J. Braz. Chem. Soc.. Publicado em: 21/10/2019
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20. Doxycycline release and antibacterial activity from PMMA/PEO electrospun fiber mats
Abstract Objective: To investigate the use of polymethyl methacrylate (PMMA) electrospun fiber mats containing different amounts of polyethylene oxide (PEO) as a doxycycline delivery system and to test antibacterial activity against an oral pathogen. Methodology: PMMA powders or PEO (mol wt 200 Kd) (10,20,30% w/w/) were dissolved in N, N-dimethylformamide
J. Appl. Oral Sci.. Publicado em: 07/10/2019
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21. Study of erythrocytes as a novel drug carrier for the delivery of artemether
Resealed erythrocytes have been explored in various dimensions of drug delivery, owing to their high biocompatibility and inability to initiate immune response. The present research was designed to evaluate the drug delivery potential of erythrocytes by loading a hydrophobic anti-malarial drug, Artemether. Three different loading techniques were applied to a
Braz. J. Pharm. Sci.. Publicado em: 30/09/2019
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22. Mass Variation Rate, in Acidic Environment, of Polyhydroxybutyrate and Chitosan matrices with Potential Application as Controlled Drug Delivery System
Polymers such as the biocompatible polyhydroxybutyrate (PHB) and the polysaccharide chitosan (Chi), a pH-sensitive polymer, have been studied for drug delivery applications and scaffolds production. In this work, matrices of PHB and Chi were produced by compression molding (SPHB-Chi) and loaded with a broad-spectrum biocide chlorhexidine (CHX) (SPHB-Chi-CHX)
Mat. Res.. Publicado em: 30/09/2019
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23. HYDROXYAPATITE - CARBON NANOTUBE COMPOSITES FOR DRUG DELIVERY APPLICATIONS
Abstract The aim of this study was the synthesis of composites containing hydroxyapatite (Hap) or silicon substituted hydroxyapatite (HapSi), carboxyl functionalized carbon nanotubes (fMWCNT) and gelatin (G) in different ratios. Ibuprofen (IBU) was chosen as a model drug for the formulation of extended-release dosage forms. The obtained composites were chara
Braz. J. Chem. Eng.. Publicado em: 30/09/2019
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24. Development and in vitro/in vivo evaluation of thermo-sensitive in situ gelling systems for ocular allergy
Ocular allergy is one of the most common disorders of the eye surface. Following diagnosis this condition is typically treated with preparations containing antihistamines. However, anatomy of the eye and its natural protective mechanisms create challenges for ocular drug delivery. Rapid elimination of antihistamine substances due to short residency times fol
Braz. J. Pharm. Sci.. Publicado em: 23/09/2019